Characterizing the Neuroimmune Environment of Offspring in a Novel Model of Maternal Allergic Asthma and Particulate Matter Exposure

[1]  P. Ashwood,et al.  Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD) , 2022, Brain, Behavior, and Immunity.

[2]  P. Ashwood,et al.  Maternal Allergic Asthma Induces Prenatal Neuroinflammation , 2022, Brain sciences.

[3]  V. Murphy.  Asthma in pregnancy - Management, maternal co-morbidities, and long-term health. , 2022, Best practice & research. Clinical obstetrics & gynaecology.

[4]  D. Schiller,et al.  Hippocampal contributions to social and cognitive deficits in autism spectrum disorder , 2021, Trends in Neurosciences.

[5]  Chetwyn C. H. Chan,et al.  PM2.5 as a potential risk factor for autism spectrum disorder: Its possible link to neuroinflammation, oxidative stress and changes in gene expression , 2021, Neuroscience & Biobehavioral Reviews.

[6]  K. McCoy,et al.  Microbiota and Microglia Interactions in ASD , 2021, Frontiers in Immunology.

[7]  A. Levin,et al.  Prenatal IgE as a Risk Factor for the Development of Childhood Neurodevelopmental Disorders , 2021, Frontiers in Pediatrics.

[8]  Marisa N. Spann,et al.  Prenatal maternal infection and risk for autism in offspring: A meta‐analysis , 2021, Autism research : official journal of the International Society for Autism Research.

[9]  N. Nassar,et al.  Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review , 2021, Translational Psychiatry.

[10]  P. Ashwood,et al.  Repeated allergic asthma in early versus late pregnancy differentially impacts offspring brain and behavior development , 2020, Brain, Behavior, and Immunity.

[11]  L. Croen,et al.  Maternal immune response and air pollution exposure during pregnancy: insights from the Early Markers for Autism (EMA) study , 2020, Journal of Neurodevelopmental Disorders.

[12]  A. Guastella,et al.  Maternal immune conditions are increased in males with autism spectrum disorders and are associated with behavioural and emotional but not cognitive co-morbidity , 2020, Translational Psychiatry.

[13]  Faria Zafar,et al.  The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders , 2020, International journal of molecular sciences.

[14]  T. Kanjevac,et al.  Interleukin-17 in Chronic Inflammatory Neurological Diseases , 2020, Frontiers in Immunology.

[15]  J. Zelikoff,et al.  Neuroinflammatory and Behavioral Outcomes Measured in Adult Offspring of Mice Exposed Prenatally to E-Cigarette Aerosols , 2020, Environmental health perspectives.

[16]  Yanqin Gao,et al.  IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury , 2020, The Journal of Immunology.

[17]  E. Greimel,et al.  Increased hippocampal shape asymmetry and volumetric ventricular asymmetry in autism spectrum disorder , 2020, NeuroImage: Clinical.

[18]  P. Ashwood,et al.  Overlapping evidence of innate immune dysfunction in psychotic and affective disorders. , 2020, Brain, behavior, & immunity - health.

[19]  B. Birnir,et al.  Interferon-γ potentiates GABAA receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons , 2019, Journal of Neuroimmunology.

[20]  S. Levy,et al.  Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development , 2019, Autism research : official journal of the International Society for Autism Research.

[21]  S. Bölte,et al.  Parental asthma and risk of autism spectrum disorder in offspring: A population and family‐based case‐control study , 2019, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[22]  P. Ashwood,et al.  Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders , 2018, Front. Cell. Neurosci..

[23]  E. Longhin,et al.  Milan winter fine particulate matter (wPM2.5) induces IL-6 and IL-8 synthesis in human bronchial BEAS-2B cells, but specifically impairs IL-8 release. , 2018, Toxicology in vitro : an international journal published in association with BIBRA.

[24]  Shin-Young Park,et al.  Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells , 2018, Molecular brain.

[25]  Gregory H Gorman,et al.  Prenatal, perinatal, and neonatal risk factors of autism spectrum disorder , 2018, Pediatric Research.

[26]  J. Gustafsson,et al.  Liver X receptor β regulates the development of the dentate gyrus and autistic-like behavior in the mouse , 2018, Proceedings of the National Academy of Sciences.

[27]  Markus Brauer,et al.  Linear Mixed-Effects Models and the Analysis of Nonindependent Data: A Unified Framework to Analyze Categorical and Continuous Independent Variables that Vary Within-Subjects and/or Within-Items , 2017, Psychological methods.

[28]  J. Zelikoff,et al.  Perinatal exposure to concentrated ambient particulates results in autism‐like behavioral deficits in adult mice , 2017, Neurotoxicology.

[29]  J. LaSalle,et al.  Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism , 2017, bioRxiv.

[30]  Stanley E Lazic,et al.  What exactly is ‘N’ in cell culture and animal experiments? , 2017, bioRxiv.

[31]  P. Ashwood,et al.  Behavioral impact of maternal allergic-asthma in two genetically distinct mouse strains , 2017, Brain, Behavior, and Immunity.

[32]  R. Auten,et al.  Gestational Exposure to Air Pollution Alters Cortical Volume, Microglial Morphology, and Microglia-Neuron Interactions in a Sex-Specific Manner , 2017, Front. Synaptic Neurosci..

[33]  G Cioni,et al.  Network over‐connectivity differentiates autism spectrum disorder from other developmental disorders in toddlers: A diffusion MRI study , 2017, Human brain mapping.

[34]  F. Brombacher,et al.  IL-13–Mediated Regulation of Learning and Memory , 2017, The Journal of Immunology.

[35]  A. Reichenberg,et al.  Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses , 2017, Molecular Autism.

[36]  C. Ecker.  The neuroanatomy of autism spectrum disorder: An overview of structural neuroimaging findings and their translatability to the clinical setting , 2017, Autism : the international journal of research and practice.

[37]  H. Goossens,et al.  Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model , 2016, Journal of Neuroinflammation.

[38]  Zong-xin Ling,et al.  Maternal infection during pregnancy and risk of autism spectrum disorders: A systematic review and meta-analysis , 2016, Brain, Behavior, and Immunity.

[39]  H. Goossens,et al.  Interleukin‐13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages , 2016, Glia.

[40]  Brian D. Mills,et al.  Running header : Prenatal domoic acid exposure , sociality , and connectivity 1 Title : Prenatal domoic acid exposure disrupts mouse pro-social behavior and functional connectivity MRI , 2016 .

[41]  U. Meyer,et al.  Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies , 2016, Brain, Behavior, and Immunity.

[42]  Zhiping Weng,et al.  Unexpected role of interferon-γ in regulating neuronal connectivity and social behavior , 2016, Nature.

[43]  B. Rothen‐Rutishauser,et al.  Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms , 2016, Archives of Toxicology.

[44]  Daniel H. Geschwind,et al.  Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders , 2016, Nature Communications.

[45]  S. Nordin,et al.  Symptom-trigger factors other than allergens in asthma and allergy , 2016, International journal of environmental health research.

[46]  Y. Ikegaya,et al.  Microglia in the pathogenesis of autism spectrum disorders , 2015, Neuroscience Research.

[47]  M. Iruretagoyena,et al.  Opposing Roles of Interferon-Gamma on Cells of the Central Nervous System in Autoimmune Neuroinflammation , 2015, Front. Immunol..

[48]  G. Réus,et al.  The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders , 2015, Neuroscience.

[49]  P. Ashwood,et al.  Allergic fetal priming leads to developmental, behavioral and neurobiological changes in mice , 2015, Translational Psychiatry.

[50]  B. Budziszewska,et al.  Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells , 2015, Front. Cell. Neurosci..

[51]  Francine Laden,et al.  Autism Spectrum Disorder and Particulate Matter Air Pollution before, during, and after Pregnancy: A Nested Case–Control Analysis within the Nurses’ Health Study II Cohort , 2014, Environmental health perspectives.

[52]  B. Ritz,et al.  In Utero Exposure to Toxic Air Pollutants and Risk of Childhood Autism , 2014, Epidemiology.

[53]  Irene Knuesel,et al.  Maternal immune activation and abnormal brain development across CNS disorders , 2014, Nature Reviews Neurology.

[54]  D. Amaral,et al.  Stereological Study of Amygdala Glial Populations in Adolescents and Adults with Autism Spectrum Disorder , 2014, PloS one.

[55]  A. Barski,et al.  Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation , 2014, Mucosal Immunology.

[56]  J. Daniels,et al.  Particulate Matter Exposure, Prenatal and Postnatal Windows of Susceptibility, and Autism Spectrum Disorders , 2015, Epidemiology.

[57]  Kathryn Roeder,et al.  Most genetic risk for autism resides with common variation , 2014, Nature Genetics.

[58]  Xiao-Bing Yuan,et al.  Interleukin-1 beta guides the migration of cortical neurons , 2014, Journal of Neuroinflammation.

[59]  J. Balmes,et al.  Outdoor air pollution and asthma , 2014, The Lancet.

[60]  Zhili Zuo,et al.  PM2.5 in China: Measurements, sources, visibility and health effects, and mitigation , 2014 .

[61]  R. Kana,et al.  The Implications of Brain Connectivity in the Neuropsychology of Autism , 2014, Neuropsychology Review.

[62]  J. Lucas,et al.  Summary health statistics for U.S. adults: national health interview survey, 2012. , 2014, Vital and health statistics. Series 10, Data from the National Health Survey.

[63]  D. Rossignol,et al.  Environmental toxicants and autism spectrum disorders: a systematic review , 2014, Translational Psychiatry.

[64]  I. Hertz-Picciotto,et al.  Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay , 2013, Journal of autism and developmental disorders.

[65]  J. Sheehan,et al.  Reciprocal modulation of C/EBP‐α and C/EBP‐β by IL‐13 in activated microglia prevents neuronal death , 2013, European journal of immunology.

[66]  P. Gibson,et al.  Prenatal origins of bronchiolitis: protective effect of optimised asthma management during pregnancy , 2013, Thorax.

[67]  D. Raj,et al.  Microglial Phenotype and Adaptation , 2013, Journal of Neuroimmune Pharmacology.

[68]  Huahao Shen,et al.  Maternal exposure to combustion generated PM inhibits pulmonary Th1 maturation and concomitantly enhances postnatal asthma development in offspring , 2013, Particle and Fibre Toxicology.

[69]  P. Patterson,et al.  Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development , 2013, Brain, Behavior, and Immunity.

[70]  Francine Laden,et al.  Perinatal Air Pollutant Exposures and Autism Spectrum Disorder in the Children of Nurses’ Health Study II Participants , 2013, Environmental health perspectives.

[71]  C. Ulrik,et al.  Incidence and risk factors for exacerbations of asthma during pregnancy , 2013, Journal of asthma and allergy.

[72]  A. Jacquet.  Innate Immune Responses in House Dust Mite Allergy , 2013, ISRN allergy.

[73]  L. Garcia-Segura,et al.  Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice , 2013, Brain, Behavior, and Immunity.

[74]  Shinichi Nakagawa,et al.  Nested by design: model fitting and interpretation in a mixed model era , 2013 .

[75]  I. McKeague,et al.  Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort , 2012, Molecular Psychiatry.

[76]  S. Lazic,et al.  Improving basic and translational science by accounting for litter-to-litter variation in animal models , 2012, BMC Neuroscience.

[77]  Kathryn Roeder,et al.  Common genetic variants, acting additively, are a major source of risk for autism , 2012, Molecular Autism.

[78]  G. Hoyle,et al.  Tumor necrosis factor-α mediates interactions between macrophages and epithelial cells underlying proinflammatory gene expression induced by particulate matter. , 2012, Toxicology.

[79]  G. Barker,et al.  Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome , 2012, Autism research : official journal of the International Society for Autism Research.

[80]  M. Won,et al.  Microglia in the normally aged hippocampus , 2011, Laboratory animal research.

[81]  K. Oedegaard,et al.  Adult attention deficit hyperactivity disorder is associated with asthma , 2011, BMC psychiatry.

[82]  Cathleen K. Yoshida,et al.  Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study , 2011, Molecular autism.

[83]  S. Simmons,et al.  Ambient Particulate Matter Induces Interleukin-8 Expression through an Alternative NF-κB (Nuclear Factor-Kappa B) Mechanism in Human Airway Epithelial Cells , 2011, Environmental health perspectives.

[84]  K. Roeder,et al.  Do common variants play a role in risk for autism? Evidence and theoretical musings , 2011, Brain Research.

[85]  Lora D. Delwiche,et al.  Residential Proximity to Freeways and Autism in the CHARGE Study , 2010, Environmental health perspectives.

[86]  E. Courchesne,et al.  Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism , 2010, Biological Psychiatry.

[87]  Indira Tendolkar,et al.  Amygdala and hippocampus enlargement during adolescence in autism. , 2010, Journal of the American Academy of Child and Adolescent Psychiatry.

[88]  Erik T Parner,et al.  Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders , 2010, Journal of autism and developmental disorders.

[89]  Jan Czerwinski,et al.  Metal-Oxide Particles in Combustion Engine Exhaust , 2010 .

[90]  Kevin R. Smith,et al.  Oxidative Injury in The Lungs of Neonatal Rats Following Short-Term Exposure to Ultrafine Iron and Soot Particles , 2010, Journal of toxicology and environmental health. Part A.

[91]  Isabelle Wolowczuk,et al.  Interleukin-7, a New Cytokine Targeting the Mouse Hypothalamic Arcuate Nucleus: Role in Body Weight and Food Intake Regulation , 2010, PloS one.

[92]  P. Patterson.  Immune involvement in schizophrenia and autism: Etiology, pathology and animal models , 2009, Behavioural Brain Research.

[93]  M. Beauchesne,et al.  Control and severity of asthma during pregnancy are associated with asthma incidence in offspring: two-stage case–control study , 2009, European Respiratory Journal.

[94]  Kevin R. Smith,et al.  Mechanisms of particulate matter toxicity in neonatal and young adult rat lungs. , 2008, Research report.

[95]  G. Diette,et al.  Asthma in the inner city and the indoor environment. , 2008, Immunology and allergy clinics of North America.

[96]  Romain Neugebauer,et al.  Air Pollution and Pulmonary Function in Asthmatic Children: Effects of Prenatal and Lifetime Exposures , 2008, Epidemiology.

[97]  D. Zeldin,et al.  Exposure to multiple indoor allergens in US homes and its relationship to asthma. , 2008, The Journal of allergy and clinical immunology.

[98]  Joel A Dubin,et al.  Advantages of mixed effects models over traditional ANOVA models in developmental studies: a worked example in a mouse model of fetal alcohol syndrome. , 2007, Developmental psychobiology.

[99]  Nathalie Arbour,et al.  Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation , 2007, Nature Medicine.

[100]  Jonathan I. Levy,et al.  Synergistic Effects of Traffic-Related Air Pollution and Exposure to Violence on Urban Asthma Etiology , 2007, Environmental health perspectives.

[101]  M. Reite,et al.  Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms , 2006, BMC psychiatry.

[102]  J. Jasinski,et al.  Spatially Resolved Energy Electron Loss Spectroscopy Studies of Iron Oxide Nanoparticles , 2006, Microscopy and Microanalysis.

[103]  M. Mattson,et al.  Interferon‐γ is up‐regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity , 2006, Journal of neuroscience research.

[104]  P. Gibson,et al.  Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes , 2006, Thorax.

[105]  P. Gibson,et al.  Severe Asthma Exacerbations During Pregnancy , 2005, Obstetrics and gynecology.

[106]  M. Atkinson,et al.  Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice , 2005, Brain Research.

[107]  M. King,et al.  IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: relation to development and neurotrophins , 2005, Journal of Neuroimmunology.

[108]  Cathleen K. Yoshida,et al.  Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study. , 2005, Archives of pediatrics & adolescent medicine.

[109]  Günter Oberdörster,et al.  Ultrafine particle deposition in subjects with asthma. , 2004, Environmental health perspectives.

[110]  K. Pinkerton,et al.  Oxidative stress and NFkappaB activation in the lungs of rats: a synergistic interaction between soot and iron particles. , 2003, Toxicology and applied pharmacology.

[111]  Jorge R. Oksenberg,et al.  Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis , 2002, Nature Medicine.

[112]  T. Holford,et al.  Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density. , 2002, Environmental health perspectives.

[113]  P. Gluck,et al.  The effect of pregnancy on the course of asthma. , 2000, Immunology and allergy clinics of North America.

[114]  M. Michaelson,et al.  Interleukin-7 is trophic for embryonic neurons and is expressed in developing brain. , 1996, Developmental biology.

[115]  S. Furukawa,et al.  Interleukin‐2 as a neurotrophic factor for supporting the survival of neurons cultured from various regions of fetal rat brain , 1993, Journal of Neuroscience Research.

[116]  Kent E. Pinkerton,et al.  Repeated Iron–Soot Exposure and Nose-to-brain Transport of Inhaled Ultrafine Particles , 2018, Toxicologic pathology.

[117]  Irva Hertz-Picciotto,et al.  Traffic-related air pollution, particulate matter, and autism. , 2013, JAMA psychiatry.

[118]  D. Nowak,et al.  Effects of particulate matter on cytokine production in vitro: a comparative analysis of published studies. , 2008, Inhalation toxicology.