3.0T MR-guided laser ablation of a prostate cancer recurrence in the postsurgical prostate bed.

Biochemical recurrence of prostate cancer after definitive therapy with radical prostatectomy occurs in 25%-30% of cases. The first known case of magnetic resonance (MR) imaging-guided ablation using laser interstitial thermal therapy (LITT) for locally recurrent prostate cancer after radical prostatectomy is presented. Using 3.0T MR guidance, two laser applicators were placed via a transperineal approach. Laser ablation was performed using MR thermometry to determine the ablation endpoint and lesion coverage. Dynamic contrast-enhanced MR imaging after the procedure showed no definitive abnormal enhancement. The patient had no change in continence or potency after the procedure.

[1]  William J Catalona,et al.  Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results. , 2004, The Journal of urology.

[2]  M. Resnick,et al.  Analysis of recent trends in prostate cancer incidence and mortality , 2000, The Prostate.

[3]  J. Eastham Re: Prostate Cancer–Specific Survival Following Salvage Radiotherapy versus Observation in Men with Biochemical Recurrence after Radical Prostatectomy , 2009 .

[4]  D. Kuban,et al.  Long-term multi-institutional analysis of stage T1-T2 prostate cancer treated with radiotherapy in the PSA era. , 2003, International journal of radiation oncology, biology, physics.

[5]  A. Jemal,et al.  Cancer Statistics, 2009 , 2009, CA: a cancer journal for clinicians.

[6]  S R J Bott,et al.  Management of recurrent disease after radical prostatectomy , 2004, Prostate Cancer and Prostatic Diseases.

[7]  Roger J. McNichols,et al.  Percutaneous MRI-guided laser thermal therapy in canine prostate , 2005, SPIE BiOS.

[8]  Haishan Zeng,et al.  Photonic Therapeutics and Diagnostics IX , 2013 .

[9]  I. Floriani,et al.  Endorectal and dynamic contrast-enhanced MRI for detection of local recurrence after radical prostatectomy. , 2008, AJR. American journal of roentgenology.

[10]  A. Partin,et al.  Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience. , 2001, The Urologic clinics of North America.

[11]  M. Blute,et al.  Treatment of prostate cancer local recurrence after radical retropubic prostatectomy with 17-gauge interstitial transperineal cryoablation: initial experience. , 2007, Urology.

[12]  A W Partin,et al.  Natural history of progression after PSA elevation following radical prostatectomy. , 1999, JAMA.

[13]  Ashok Gowda,et al.  MR thermometry‐based feedback control of laser interstitial thermal therapy at 980 nm , 2004, Lasers in surgery and medicine.

[14]  Misop Han,et al.  Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy. , 2008, JAMA.

[15]  Nathan Lawrentschuk,et al.  Focal therapy in prostate cancer: modalities, findings and future considerations , 2010, Nature Reviews Urology.