Differential cell death response to photodynamic therapy is dependent on dose and cell type

PDT-induced cell death, by either apoptosis or necrosis may vary with cell type or PDT dose. 5 cell types were treated with varying doses of aminolaevulinic acid-induced PDT and the type of cell death analysed. The mode of cell death was found to depend on both cell type and light dose. © 2001 Cancer Research Campaign

[1]  G. Fleuren,et al.  Specificity of seven monoclonal antibodies against p53 evaluated with Western blotting, immunohistochemistry, confocal laser scanning microscopy, and flow cytometry. , 1997, Cytometry.

[2]  S. Ben‐Sasson,et al.  Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation , 1992, The Journal of cell biology.

[3]  K. Honn,et al.  Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[4]  J. Gray,et al.  Cell cycle analysis by flow cytometry. , 1979, Methods in enzymology.

[5]  Alan G. Porter,et al.  Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis* , 1998, The Journal of Biological Chemistry.

[6]  T. Stokke,et al.  Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light , 1999, British Journal of Cancer.

[7]  David Kessel,et al.  Mechanisms of phototoxicity catalyzed by two porphycenes , 1995, Photonics West.

[8]  C. B. Srikant,et al.  Induction of wild‐type p53, Bax, and acidic endonuclease during somatostatin‐signaled apoptosis in MCF‐7 human breast cancer cells , 1998, International journal of cancer.

[9]  G. Kroemer,et al.  Mitochondria as regulators of apoptosis: doubt no more. , 1998, Biochimica et biophysica acta.

[10]  S. Schwartz,et al.  p53 mutations in bladder carcinoma cell lines. , 1994, Oncology research.

[11]  J. Gray,et al.  [19] Cell cycle analysis by flow cytometry , 1979 .