On the distribution of frequencies of mutation to genes determining harmful traits in man.

Abstract An attempt has been made, based on findings in a number of population surveys, the findings of others in similar studies, and the literature to compare frequencies of X-linked traits in man and the relevant gene mutation rates. It is suggested that the evidence points to the mean level of mutation rates to visibles being at least an order or magnitude lower than those which would be derived from published mutation rate estimates and which have been used in a number of contexts, notably in estimates of the hazards of radiation to man. It is further suggested that a distribution such as the one which results from these studies underrepresents very low frequency traits and correspondingly low mutation rates.

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