Determinants of bone mass in postmenopausal women.

Eighty white women, mean age 52 years, within one to six years postmenopausal, were studied to examine the relationship of various factors to bone mass. Forty-four of the women had annual measurements of bone mass, so that the rate of bone loss could be determined. Bone mass was measured by total body neutron activation analysis and photon absorptiometry of the distal radius (total body calcium [TBCa] and bone mineral content [BMC], respectively). Breast-feeding and pregnancy were noted to be associated with higher bone mass; those with lower BMC and/or TBCa tended to have higher serum alkaline phosphatase levels, lower testosterone levels, and more years since the cessation of menses. The rate of bone loss from the radius was greater in those with higher parathyroid hormone levels; those with reduced dietary intake of calcium and lower 25-hydroxyvitamin D levels had a greater rate of loss of TBCa.

[1]  J. Aloia,et al.  Rate of bone loss in postmenopausal and osteoporotic women. , 1982, The American journal of physiology.

[2]  A. Horsman,et al.  The relation between bone loss and calcium balance in women. , 1980, Clinical science.

[3]  H. DeLuca,et al.  Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. , 1979, The Journal of clinical investigation.

[4]  H. Orimo,et al.  Role of calcium regulating hormones in the pathogenesis of senile osteoporosis. , 1979, Endocrinologia japonica.

[5]  M. Harasawa,et al.  Endocrine factors in senile osteoporosis. , 1979, Endocrinologia japonica.

[6]  R. Recker,et al.  Effect of estrogens and calcium carbonate on bone loss in postmenopausal women. , 1977, Annals of internal medicine.

[7]  H. DeLuca,et al.  A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma. , 1976, Archives of biochemistry and biophysics.

[8]  M. Surks,et al.  Replacement Treatment of Hypothyroidism , 1974 .

[9]  H. Atkins,et al.  Absolute and relative deficit in total-skeletal calcium and radial bone mineral in osteoporosis. , 1974, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  J. Aloia,et al.  Alteration in elemental body composition in thyroid disorders. , 1973, The Journal of clinical endocrinology and metabolism.

[11]  P. Saville,et al.  Intestinal calcium absorption: concurrent use of oral and intravenous tracers and calculation by the inverse convolution method. , 1972, The Journal of laboratory and clinical medicine.

[12]  J. Haddad,et al.  COMPETITIVE PROTEIN-BINDING RADIOASSAY FOR 25-HYDROXYCHOLECALCIFEROL1 , 1971 .

[13]  S. Yen,et al.  The effect of ethinyl estradiol administration during early follicular phase of the cycle on the gonadotropin levels and ovarian function. , 1971, The Journal of clinical endocrinology and metabolism.

[14]  S. Cohn,et al.  Measurement of total-body calcium, sodium, chlorine, nitrogen, and phosphorus in man by in vivo neutron activation analysis. , 1971, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[15]  R. West,et al.  LOSS OF SKELETAL CALCIUM IN LACTATING WOMEN , 1970, The Journal of obstetrics and gynaecology of the British Commonwealth.

[16]  J S Robertson,et al.  A whole-body counter with an invariant response to radionuclide distribution and body size. , 1969, Physics in medicine and biology.

[17]  J A Sorenson,et al.  Precision and accuracy of bone mineral determination by direct photon absorptiometry. , 1968, Investigative radiology.

[18]  C. Rich,et al.  A double isotope method for measurement of intestinal absorption of calcium in man. , 1965, The Journal of laboratory and clinical medicine.