Xenohormesis: Sensing the Chemical Cues of Other Species

Many plant molecules interact with and modulate key regulators of mammalian physiology in ways that are beneficial to health, but why? We propose that heterotrophs (animals and fungi) are able to sense chemical cues synthesized by plants and other autotrophs in response to stress. These cues provide advance warning about deteriorating environmental conditions, allowing the heterotrophs to prepare for adversity while conditions are still favorable.

[1]  Mohammad Saleem,et al.  Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. , 2006, Cancer research.

[2]  M. Mattson,et al.  Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses , 2006, Trends in Neurosciences.

[3]  R. Welti,et al.  Arabidopsis sfd Mutants Affect Plastidic Lipid Composition and Suppress Dwarfing, Cell Death, and the Enhanced Disease Resistance Phenotypes Resulting from the Deficiency of a Fatty Acid Desaturase Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/ , 2003, The Plant Cell Online.

[4]  J. Pezzuto,et al.  Human, Rat, and Mouse Metabolism of Resveratrol , 2002, Pharmaceutical Research.

[5]  B. Aggarwal,et al.  Curcumin as "Curecumin": from kitchen to clinic. , 2008, Biochemical pharmacology.

[6]  R. Rosenfeld Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[7]  L. Guarente,et al.  A therapeutic role for sirtuins in diseases of aging? , 2007, Trends in biochemical sciences.

[8]  D M Goldberg,et al.  Resveratrol: a molecule whose time has come? And gone? , 1997, Clinical biochemistry.

[9]  Marc K Hellerstein,et al.  Alternate-day fasting and chronic disease prevention: a review of human and animal trials. , 2007, The American journal of clinical nutrition.

[10]  H. A. Stafford Flavonoid evolution: an enzymic approach. , 1991, Plant physiology.

[11]  Sylvain Doré,et al.  Unique Properties of Polyphenol Stilbenes in the Brain: More than Direct Antioxidant Actions; Gene/Protein Regulatory Activity , 2005, Neurosignals.

[12]  M. Hawes,et al.  Flavonoids: from cell cycle regulation to biotechnology , 2005, Biotechnology Letters.

[13]  Joseph A. Baur,et al.  Therapeutic potential of resveratrol: the in vivo evidence , 2006, Nature Reviews Drug Discovery.

[14]  A. Leslie,et al.  Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols , 2007, Proceedings of the National Academy of Sciences.

[15]  Peter McCourt,et al.  Hormone evolution: The key to signalling , 2003, Nature.

[16]  Phuong Chung,et al.  Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan , 2003, Nature.

[17]  J. Schultz Shared Signals and the Potential for Phylogenetic Espionage Between Plants and Animals1 , 2002, Integrative and comparative biology.

[18]  E. Grotewold,et al.  Flavonoids as developmental regulators. , 2005, Current opinion in plant biology.

[19]  J. Botto,et al.  The plant cell , 2007, Plant Molecular Biology Reporter.

[20]  N. Gunde-Cimerman,et al.  Mycosporines and mycosporine-like amino acids: UV protectants or multipurpose secondary metabolites? , 2007, FEMS microbiology letters.

[21]  V. Brown,et al.  Effects of root herbivory by an insect on a foliar-feeding species, mediated through changes in the host plant , 1989, Oecologia.

[22]  Joseph Rafter,et al.  Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? , 2005, The American journal of clinical nutrition.

[23]  J. Wood,et al.  Sirtuin activators mimic caloric restriction and delay ageing in metazoans , 2004, Nature.

[24]  Craig M. Crews,et al.  Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials , 2007, Cell.