New semi-interpenetrating network hydrogels: synthesis, characterization and properties.

Amphiphilic hydrogels composed of aliphatic polyesters and poly(ethylene glycol) have potential applications in drug delivery, tissue engineering and other biomedical devices due to their advantageous biological properties, biocompatibility and biodegradability. However, they also exhibit some shortcomings in terms of their reactivity, swelling and mechanical properties. To address these limitations, new semi-interpenetrating network (semi-IPN) hydrogels based on poly(ethylene glycol)-co-poly(epsilon-caprolactone) (PEG-PCL) diacrylate macromer and hydroxypropyl guar gum (HPGG) were prepared by a low intensity ultraviolet (UV) light irradiation method, and characterized by FT-IR, DSC and WAXD analysis. Their properties were evaluated by investigating the swelling kinetics, dynamic mechanical rheology and the release behavior for bovine serum albumin (BSA). It was found that the introduction of the semi-IPN structure and HPGG decreased the crystallinity of PEG segments in the hydrogel, and improved the swelling and mechanical properties of the hydrogel, as well as lowered the release percentage of BSA from the hydrogel. Such hydrogel materials may have more advantages as a potentially interesting platform for the design of medical devices.The elastic modulus (G') and viscous modulus (G'') as a function of frequency for various hydrogel samples.

[1]  Antonios G. Mikos,et al.  Delivery of TGF-β1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications , 2005 .

[2]  Michiya Matsusaki,et al.  Novel functional biodegradable polymer IV: pH-sensitive controlled release of fibroblast growth factor-2 from a poly(gamma-glutamic acid)-sulfonate matrix for tissue engineering. , 2005, Biomacromolecules.

[3]  T. Guo,et al.  Hemoglobin recognition by imprinting in semi-interpenetrating polymer network hydrogel based on polyacrylamide and chitosan. , 2005, Biomacromolecules.

[4]  Li Yan,et al.  Perspectives on: Strategies to Fabricate Starch-based Hydrogels with Potential Biomedical Applications , 2005 .

[5]  S. Khwarg,et al.  An open-label evaluation of HP‐Guar gellable lubricant eye drops for the improvement of dry eye signs and symptoms in a moderate dry eye adult population , 2005, Current medical research and opinion.

[6]  E. Schacht,et al.  Tailor-made polymers for local drug delivery: release of macromolecular model drugs from biodegradable hydrogels based on poly(ethylene oxide). , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[7]  J. Filipović,et al.  Poly(acrylamide‐co‐itaconic acid) and Semi‐IPNS with Poly(ethylene glycol): Preparation and Characterization , 2004 .

[8]  R. Zhuo,et al.  Temperature-sensitive polyamidoamine dendrimer/poly(N-isopropylacrylamide) hydrogels with improved responsive properties. , 2004, Macromolecular bioscience.

[9]  C. van Nostrum,et al.  Biodegradable dextran hydrogels crosslinked by stereocomplex formation for the controlled release of pharmaceutical proteins. , 2004, International journal of pharmaceutics.

[10]  S. Tammishetti,et al.  Synthesis, UV photo‐polymerization and degradation study of PEG containing polyester polyol acrylates , 2004 .

[11]  Y. Choi,et al.  Kinetic characterization of swelling of liquid crystalline phases of glyceryl monooleate , 2003, Archives of pharmacal research.

[12]  C. Ober,et al.  Surface patterning and biological evaluation of semi-interpenetrated poly(HEMA)/poly(alkyl β-malolactonate)s , 2003 .

[13]  K. Yao,et al.  State of water in the pH‐sensitive chitosan‐polyether semi‐IPN hydrogel , 2003 .

[14]  Mikael Wiberg,et al.  A novel biodegradable implant for neuronal rescue and regeneration after spinal cord injury. , 2002, Biomaterials.

[15]  K. Healy,et al.  Poly(N-isopropylacrylamide)-based semi-interpenetrating polymer networks for tissue engineering applications. 1. Effects of linear poly(acrylic acid) chains on phase behavior. , 2002, Biomacromolecules.

[16]  Allan S Hoffman,et al.  Hydrogels for biomedical applications. , 2002, Advanced drug delivery reviews.

[17]  Zainuddin,et al.  Viscoelasticity of radiation-formed PVA/PVP hydrogel , 2002, Journal of biomaterials science. Polymer edition.

[18]  Nilhan Kayaman‐Apohan,et al.  Semi-Interpenetrating Hydrogel Networks of Poly(2-hydroxyethyl methacrylate) with Poly[(D,L-lactic acid)-co-(ε-caprolactam)] , 2001 .

[19]  K. Br,et al.  Current status of DNA vaccines in veterinary medicine. , 2000 .

[20]  C. McCormick,et al.  Microstructural Examination of Semi-Interpenetrating Networks of Poly(N,N-dimethylacrylamide) with Cellulose or Chitin Synthesized in Lithium Chloride/N,N-Dimethylacetamide , 1998 .

[21]  Y. Ikada,et al.  Biodegradable hydrogels for bone regeneration through growth factor release , 1998 .

[22]  Jeffrey A. Hubbell,et al.  Synthesis of Polymer Network Scaffolds from l-Lactide and Poly(ethylene glycol) and Their Interaction with Cells , 1997 .

[23]  Y. Lee,et al.  Hydrogels of poly(ethylene glycol)-co-poly(lactones) diacrylate macromers and β-chitin , 1997 .

[24]  K. Yao,et al.  A study on correlation between water state and swelling kinetics of chitosan-based hydrogels , 1996 .

[25]  H. Schott,et al.  Kinetics of swelling of polymers and their gels. , 1992, Journal of pharmaceutical sciences.

[26]  K. Zhu,et al.  Preparation , Characterization , and Properties of Polylactide ( PLA )-Poly ( ethylene Glycol ) ( PEG ) Copolymers : A Potential Drug Carrier , 2017 .

[27]  D. Cohn,et al.  Biodegradable PEO/PLA block copolymers. , 1988, Journal of biomedical materials research.

[28]  Nicholas A. Peppas,et al.  A simple equation for description of solute release II. Fickian and anomalous release from swellable devices , 1987 .

[29]  B. Baysal,et al.  Interpenetrating hydrogel networks based on polyacrylamide and poly(itaconic acid): synthesis and characterization , 1999 .

[30]  Y. Lee,et al.  Synthesis and properties of semi-interpenetrating polymer networks composed of β-chitin and poly(ethylene glycol) macromer , 1995 .

[31]  M. Huglin,et al.  States of water in poly(methyl methacrylate-co-N-vinyl-2-pyrrolidone) hydrogels during swelling , 1994 .

[32]  Jeffrey A. Hubbell,et al.  Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers , 1993 .