Model misspecification detection by means of Multiple Generator Errors, using the observed potential map

SummaryDue to model misspecification, currently-used Dipole Source Localization (DSL) methods may contain Multiple-Generator Errors (MulGenErrs) when fitting simultaneously-active dipoles. The size of the MulGenErr is a function of both the model used, and the dipole parameters, including the dipoles' waveforms (time-varying magnitudes). For a given fitting model, by examining the variation of the MulGenErrs (or the fit parameters) under different waveforms for the same generating-dipoles, the accuracy of the fitting model for this set of dipoles can be determined. This method of testing model misspecification can be applied to evoked potential maps even when the parameters of the generating-dipoles are unknown. The dipole parameters fitted in a model should only be accepted if the model can be shown to be sufficiently accurate.

[1]  D L Jewett,et al.  Insidious errors in dipole localization parameters at a single time-point due to model misspecification of number of shells. , 1993, Electroencephalography and clinical neurophysiology.

[2]  Christoph Baumgartner,et al.  Investigation of multiple simultaneously active brain sources in the electroencephalogram , 1989, Journal of Neuroscience Methods.

[3]  G. C. Quarton,et al.  The neurosciences : a study program , 1967 .

[4]  A. Van Rotterdam,et al.  Limitations and Difficulties in Signal Processing by Means of the Principal-Components Analysis , 1970 .

[5]  J. P. Ary,et al.  Location of Sources of Evoked Scalp Potentials: Corrections for Skull and Scalp Thicknesses , 1981, IEEE Transactions on Biomedical Engineering.

[6]  J. D. Munck.  The estimation of time varying dipoles on the basis of evoked potentials. , 1990 .

[7]  N. Galloway,et al.  Evoked Potentials , 1987 .

[8]  G. H. Bishop.  Potential phenomena in thalamus and cortex. , 1949, Electroencephalography and clinical neurophysiology.

[9]  D. Sholl.  The organization of the cerebral cortex , 1957 .

[10]  M Scherg,et al.  Spatio-temporal modelling of early auditory evoked potentials. , 1984, Revue de laryngologie - otologie - rhinologie.

[11]  C C Wood,et al.  Principal component analysis of event-related potentials: simulation studies demonstrate misallocation of variance across components. , 1984, Electroencephalography and clinical neurophysiology.

[12]  William Martin,et al.  The 3-channel Lissajous' trajectory of the auditory brain-stem response. I. Introduction and overview , 1987 .

[13]  J.C. Mosher,et al.  Multiple dipole modeling and localization from spatio-temporal MEG data , 1992, IEEE Transactions on Biomedical Engineering.

[14]  D H Fender,et al.  The dimensionality of the human visual evoked scalp potential. , 1976, Electroencephalography and clinical neurophysiology.

[15]  D. Jewett,et al.  Far-field potentials generated by action potentials of isolated frog sciatic nerves in a spherical volume. , 1990, Electroencephalography and clinical neurophysiology.

[16]  M A B BRAZIER,et al.  The electrical fields at the surface of the head during sleep. , 1949, Electroencephalography and clinical neurophysiology.

[17]  Don L. Jewett,et al.  Insidious errors in dipole parameters due to shell model misspecification using multiple time-points , 2005, Brain Topography.