Near-infrared laser photothermal therapy of cancer by using gold nanoparticles: Computer simulations and experiment

Abstract We describe applications of silica(core)/gold(shell) nanoparticles to photothermal therapy of spontaneous tumor of cats and dogs. The laser irradiation parameters was optimized by preliminary experiments with laboratory rats. The temperature distribution in tissue and solution samples was measured with a thermal imaging system. It is shown that the temperature in the volume region of nanoparticles localization can substantially exceed the surface temperature recorded by the thermal imaging system. We demonstrate effective optical destruction of cancer cells by local injection of plasmon-resonant gold nanoshells followed by continuous wave (CW) semiconductor laser irradiation at wavelength 808 nm.

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