From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly.

[1]  Junmei Wang,et al.  Arf GTPase activates the WAVE regulatory complex through a distinct binding site , 2022, Science advances.

[2]  K. Rottner,et al.  Ena/VASP clustering at microspike tips involves lamellipodin but not I-BAR proteins, and absolutely requires unconventional myosin-X , 2022, bioRxiv.

[3]  P. Lappalainen,et al.  Biochemical and mechanical regulation of actin dynamics , 2022, Nature Reviews Molecular Cell Biology.

[4]  A. Freeman,et al.  HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions , 2022, Journal of Clinical Immunology.

[5]  A. Babataheri,et al.  PPP2R1A Regulates Migration Persistence through the WAVE Shell Complex , 2022, bioRxiv.

[6]  Baoyu Chen,et al.  WASP family proteins: Molecular mechanisms and implications in human disease. , 2022, European journal of cell biology.

[7]  Glen M. Hocky,et al.  Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy , 2022, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Peggy I. Paschke,et al.  The Scar/WAVE complex drives normal actin protrusions without the Arp2/3 complex, but proline-rich domains are required , 2022, bioRxiv.

[9]  K. Rottner,et al.  Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase , 2022, bioRxiv.

[10]  K. Rottner,et al.  Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria , 2022, Current Biology.

[11]  B. Nolen,et al.  Unconcerted conformational changes in Arp2/3 complex integrate multiple activating signals to assemble functional actin networks , 2022, Current Biology.

[12]  Kuan-Chung Su,et al.  The phenotypic landscape of essential human genes , 2021, Cell.

[13]  A. Gautreau,et al.  Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration , 2021, Nature Cell Biology.

[14]  A. Gautreau,et al.  Nucleation, stabilization, and disassembly of branched actin networks. , 2021, Trends in cell biology.

[15]  K. Rottner,et al.  A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks , 2021, Nature Communications.

[16]  K. Rottner,et al.  Lamellipodia-like actin networks in cells lacking WAVE regulatory complex , 2021, bioRxiv.

[17]  O. Weiner,et al.  The WAVE complex associates with sites of saddle membrane curvature , 2021, The Journal of cell biology.

[18]  Tai-De Li,et al.  The molecular mechanism of load adaptation by branched actin networks , 2021, bioRxiv.

[19]  K. Rottner,et al.  WAVE regulatory complex , 2021, Current Biology.

[20]  H. Arnold,et al.  Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation , 2020, bioRxiv.

[21]  W. Wan,et al.  Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction , 2020, Nature Communications.

[22]  A. Verloes,et al.  New insights into the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and impairment of the WRC-mediated actin dynamics , 2020, Genetics in Medicine.

[23]  S. Chowdhury,et al.  Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state , 2020, Nature Structural & Molecular Biology.

[24]  V. Sirotkin,et al.  Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks , 2020, bioRxiv.

[25]  G. Charras,et al.  SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization , 2020, Nature Cell Biology.

[26]  R. Dominguez,et al.  Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism , 2020, Science Advances.

[27]  E. Derivery,et al.  The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex , 2020, Science Advances.

[28]  T. Svitkina Actin Cell Cortex: Structure and Molecular Organization. , 2020, Trends in cell biology.

[29]  K. Rottner,et al.  Molecular Dissection of Neurodevelopmental Disorder-Causing Mutations in CYFIP2 , 2020, bioRxiv.

[30]  K. Rottner,et al.  Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion , 2020, bioRxiv.

[31]  K. Rottner,et al.  Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation , 2020, Journal of Cell Science.

[32]  B. Nolen,et al.  Single-Turnover Activation of Arp2/3 Complex by Dip1 May Balance Nucleation of Linear versus Branched Actin Filaments , 2019, Current Biology.

[33]  K. Rottner,et al.  Actin dynamics in cell migration , 2019, Essays in biochemistry.

[34]  K. Rottner,et al.  Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion , 2019, Current Biology.

[35]  M. Rosen,et al.  Stoichiometry controls activity of phase-separated clusters of actin signaling proteins , 2019, Science.

[36]  K. Rottner,et al.  Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo , 2018, Current Biology.

[37]  Scott D. Hansen,et al.  WH2 and proline‐rich domains of WASP‐family proteins collaborate to accelerate actin filament elongation , 2017, The EMBO journal.

[38]  K. Rottner,et al.  Actin assembly mechanisms at a glance , 2017, Journal of Cell Science.

[39]  C. Schmeiser,et al.  Load Adaptation of Lamellipodial Actin Networks , 2017, Cell.

[40]  E. Burstein,et al.  Cellular functions of WASP family proteins at a glance , 2017, Journal of Cell Science.

[41]  K. Rottner,et al.  Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly , 2017, Molecular biology of the cell.

[42]  B. Nolen,et al.  Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex , 2016, Nature Communications.

[43]  Tai-De Li,et al.  Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks , 2016, Cell.

[44]  H. Higgs,et al.  Cell type–dependent mechanisms for formin-mediated assembly of filopodia , 2015, Molecular biology of the cell.

[45]  Kai Zhang,et al.  The structure of the dynactin complex and its interaction with dynein , 2015, Science.

[46]  Guillaume Charras,et al.  Cellular Control of Cortical Actin Nucleation , 2014, Current Biology.

[47]  N. Grishin,et al.  The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton , 2014, Cell.

[48]  B. Nolen,et al.  Dip1 Defines a Class of Arp2/3 Complex Activators that Function without Preformed Actin Filaments , 2013, Current Biology.

[49]  Klemens Rottner,et al.  Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation , 2013, Journal of Cell Science.

[50]  C. Schmeiser,et al.  Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin , 2013, Molecular biology of the cell.

[51]  Thomas D. Pollard,et al.  Actin Filament Severing by Cofilin Dismantles Actin Patches and Produces Mother Filaments for New Patches , 2013, Current Biology.

[52]  J. Bear,et al.  New insights into the regulation and cellular functions of the ARP2/3 complex , 2012, Nature Reviews Molecular Cell Biology.

[53]  Christian Schmeiser,et al.  Actin branching in the initiation and maintenance of lamellipodia , 2012, Journal of Cell Science.

[54]  D. Breitsprecher,et al.  Rocket Launcher Mechanism of Collaborative Actin Assembly Defined by Single-Molecule Imaging , 2012, Science.

[55]  Dorit Hanein,et al.  The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration , 2012, The Journal of cell biology.

[56]  Shawn M. Gomez,et al.  Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis , 2012, Cell.

[57]  Tao Liu,et al.  Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype , 2011, The Journal of cell biology.

[58]  Comert Kural,et al.  Actin dynamics counteract membrane tension during clathrin-mediated endocytosis , 2011, Nature Cell Biology.

[59]  D. King,et al.  Arp2/3 complex is bound and activated by two WASP proteins , 2011, Proceedings of the National Academy of Sciences.

[60]  Thomas D. Pollard,et al.  Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex , 2011, Proceedings of the National Academy of Sciences.

[61]  Fred Chang,et al.  Characterization of Dip1p Reveals a Switch in Arp2/3-Dependent Actin Assembly for Fission Yeast Endocytosis , 2011, Current Biology.

[62]  M. Rosen,et al.  Physical mechanisms of signal integration by WASP family proteins. , 2010, Annual review of biochemistry.

[63]  Julian Weichsel,et al.  Two competing orientation patterns explain experimentally observed anomalies in growing actin networks , 2010, Proceedings of the National Academy of Sciences.

[64]  Laurent Blanchoin,et al.  A “Primer”-Based Mechanism Underlies Branched Actin Filament Network Formation and Motility , 2010, Current Biology.

[65]  M. Kirschner,et al.  Activation of the WAVE complex by coincident signals controls actin assembly. , 2009, Molecular cell.

[66]  M. Tominaga,et al.  DIP/WISH‐deficient mice reveal Dia‐ and N‐WASP‐interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts , 2009, Genes to cells : devoted to molecular & cellular mechanisms.

[67]  C. Brautigam,et al.  Hierarchical regulation of WASP/WAVE proteins. , 2008, Molecular cell.

[68]  R. Mullins,et al.  Capping Protein Increases the Rate of Actin-Based Motility by Promoting Filament Nucleation by the Arp2/3 Complex , 2008, Cell.

[69]  Klemens Rottner,et al.  Arp2/3 complex interactions and actin network turnover in lamellipodia , 2008, The EMBO journal.

[70]  Giorgio Scita,et al.  IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions. , 2008, Trends in cell biology.

[71]  J. Taunton,et al.  Mechanism of Actin Network Attachment to Moving Membranes: Barbed End Capture by N-WASP WH2 Domains , 2007, Cell.

[72]  J. Iwasa,et al.  Spatial and Temporal Relationships between Actin-Filament Nucleation, Capping, and Disassembly , 2007, Current Biology.

[73]  T. Stradal,et al.  Protein complexes regulating Arp2/3-mediated actin assembly. , 2006, Current opinion in cell biology.

[74]  W. Song,et al.  Interaction of SPIN90 with the Arp2/3 Complex Mediates Lamellipodia and Actin Comet Tail Formation* , 2006, Journal of Biological Chemistry.

[75]  K. Rottner,et al.  N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits , 2005, Journal of Cell Science.

[76]  Gary G. Borisy,et al.  Lamellipodial Versus Filopodial Mode of the Actin Nanomachinery Pivotal Role of the Filament Barbed End , 2004, Cell.

[77]  D. Yamazaki,et al.  PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia , 2004, Nature Cell Biology.

[78]  B. Baum,et al.  Abi, Sra1, and Kette Control the Stability and Localization of SCAR/WAVE to Regulate the Formation of Actin-Based Protrusions , 2003, Current Biology.

[79]  A. Carlsson Growth velocities of branched actin networks. , 2003, Biophysical journal.

[80]  T. Takenawa,et al.  IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling , 2000, Nature.

[81]  P. Gounon,et al.  The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins , 2000, Nature Cell Biology.

[82]  T D Pollard,et al.  The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[83]  Laurent Blanchoin,et al.  Actin dynamics, architecture, and mechanics in cell motility. , 2014, Physiological reviews.