ComputeCOVID19+: Accelerating COVID-19 Diagnosis and Monitoring via High-Performance Deep Learning on CT Images

The COVID-19 pandemic has highlighted the importance of diagnosis and monitoring as early and accurately as possible. However, the reverse-transcription polymerase chain reaction (RT-PCR) test results in two issues: (1) protracted turnaround time from sample collection to testing result and (2) compromised test accuracy, as low as 67%, due to when and how the samples are collected, packaged, and delivered to the lab to conduct the RT-PCR test. Thus, we present ComputeCOVID19+, our computed tomography-based framework to improve the testing speed and accuracy of COVID-19 (plus its variants) via a deep learning-based network for CT image enhancement called DDnet, short for DenseNet and Deconvolution network. To demonstrate its speed and accuracy, we evaluate ComputeCOVID19+ across several sources of computed tomography (CT) images and on many heterogeneous platforms, including multi-core CPU, many-core GPU, and even FPGA. Our results show that ComputeCOVID19+ can significantly shorten the turnaround time from days to minutes and improve the testing accuracy to 91%.

[1]  Christine Toumoulin,et al.  Dictionary learning based sinogram inpainting for CT sparse reconstruction , 2014 .

[2]  Trevor Darrell,et al.  Fully Convolutional Networks for Semantic Segmentation , 2017, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[3]  E. Dong,et al.  An interactive web-based dashboard to track COVID-19 in real time , 2020, The Lancet Infectious Diseases.

[4]  Ali Kashif Bashir,et al.  Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) , 2013, ICIRA 2013.

[5]  J. Earls,et al.  Image reconstruction: Part 1 - understanding filtered back projection, noise and image acquisition. , 2020, Journal of cardiovascular computed tomography.

[6]  M. Biggerstaff,et al.  SARS-CoV-2 Transmission From People Without COVID-19 Symptoms , 2021, JAMA network open.

[7]  Kilian Q. Weinberger,et al.  Densely Connected Convolutional Networks , 2016, 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[8]  Wenyu Liu,et al.  Deep Learning-based Detection for COVID-19 from Chest CT using Weak Label , 2020, medRxiv.

[9]  Daguang Xu,et al.  3D Anisotropic Hybrid Network: Transferring Convolutional Features from 2D Images to 3D Anisotropic Volumes , 2017, MICCAI.

[10]  Yicheng Fang,et al.  Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR , 2020, Radiology.

[11]  A. Bruckstein,et al.  K-SVD : An Algorithm for Designing of Overcomplete Dictionaries for Sparse Representation , 2005 .

[12]  Andreas K. Maier,et al.  Deep Learning Computed Tomography , 2016, MICCAI.

[13]  Eero P. Simoncelli,et al.  Image quality assessment: from error visibility to structural similarity , 2004, IEEE Transactions on Image Processing.

[14]  CT in relation to RT-PCR in diagnosing COVID-19 in The Netherlands: A prospective study , 2020, PloS one.

[15]  M. Roser,et al.  Coronavirus Pandemic (COVID-19) , 2020 .

[16]  Jorge Nocedal,et al.  On Large-Batch Training for Deep Learning: Generalization Gap and Sharp Minima , 2016, ICLR.

[17]  X. He,et al.  Sample-Efficient Deep Learning for COVID-19 Diagnosis Based on CT Scans , 2020, medRxiv.

[18]  Bo Xu,et al.  A deep learning algorithm using CT images to screen for Corona virus disease (COVID-19) , 2020, European Radiology.

[19]  Yaoqin Xie,et al.  A Sparse-View CT Reconstruction Method Based on Combination of DenseNet and Deconvolution , 2018, IEEE Transactions on Medical Imaging.

[20]  Q. Tao,et al.  Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases , 2020, Radiology.

[21]  K. Yuen,et al.  Clinical Characteristics of Coronavirus Disease 2019 in China , 2020, The New England journal of medicine.

[22]  Feng Lin,et al.  Low-Dose CT With a Residual Encoder-Decoder Convolutional Neural Network , 2017, IEEE Transactions on Medical Imaging.

[23]  Suk-Ju Kang,et al.  An Energy-Efficient FPGA-Based Deconvolutional Neural Networks Accelerator for Single Image Super-Resolution , 2018, IEEE Transactions on Circuits and Systems for Video Technology.

[24]  Aaftab Munshi,et al.  The OpenCL specification , 2009, 2009 IEEE Hot Chips 21 Symposium (HCS).

[25]  Michael Unser,et al.  Deep Convolutional Neural Network for Inverse Problems in Imaging , 2016, IEEE Transactions on Image Processing.

[26]  Xinyu Zhang A Design Methodology for Efficient Implementation of Deconvolutional Neural Networks on an FPGA , 2017, ArXiv.

[27]  H. Demirel,et al.  Deep learning for diagnosis of COVID-19 using 3D CT scans , 2021, Computers in Biology and Medicine.

[28]  Jimmy Ba,et al.  Adam: A Method for Stochastic Optimization , 2014, ICLR.

[29]  L. Kucirka,et al.  Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction–Based SARS-CoV-2 Tests by Time Since Exposure , 2020, Annals of Internal Medicine.

[30]  Jong Chul Ye,et al.  Deep Residual Learning for Compressed Sensing CT Reconstruction via Persistent Homology Analysis , 2016, ArXiv.

[31]  R. Siddon Fast calculation of the exact radiological path for a three-dimensional CT array. , 1985, Medical physics.

[32]  K. Cao,et al.  Using Artificial Intelligence to Detect COVID-19 and Community-acquired Pneumonia Based on Pulmonary CT: Evaluation of the Diagnostic Accuracy , 2020 .

[33]  Daniel Kolditz,et al.  Iterative reconstruction methods in X-ray CT. , 2012, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[34]  Kaiming He,et al.  Momentum Contrast for Unsupervised Visual Representation Learning , 2019, 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR).

[35]  Yuedong Yang,et al.  Deep Learning Enables Accurate Diagnosis of Novel Coronavirus (COVID-19) With CT Images , 2020, IEEE/ACM Transactions on Computational Biology and Bioinformatics.

[36]  Mona G. Flores,et al.  Artificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets , 2020, Nature Communications.