Evaluation of alternative approaches for screening contaminated sediments and soils for polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans.

Traditional high resolution mass spectrometry (HRMS) analysis for polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) can be time consuming and expensive. Consequently, alternative methods are of great interest to regulatory agencies and others characterizing contaminated sites. One factor that hinders acceptance of alternative methods is a lack of performance information that assesses the alternative method's impacts on analytical results. The U.S. Environmental Protection Agency's Superfund Innovative Technology Evaluation Monitoring and Measurement Technologies Program (EPA SITE MMT) encourages the development and implementation of innovative and alternative monitoring methods by providing performance information on site characterization technologies. This paper presents a comparison of the results obtained from laboratory-based alternative approaches for screening sediment and soil samples for dioxin toxicity equivalents (TEQ(D/F)) to results obtained using traditional HRMS. The laboratory-based approaches included modifying the traditional HRMS analysis to make it more cost-effective (alternate 1613B), analyzing extracts that had been prepared for HRMS using low resolution mass spectrometry, and determining total organic carbon (TOC) content as an indicator of PCDD/F content. These comparisons demonstrated that TEQ(D/F) values generated using toxicity equivalency factors proposed by the World Health Organization in 1998 applied to alternate 1613B and LRMS analyses have a strong linear correlation to the TEQ(D/F) values derived in the same fashion from traditional HRMS analysis. These results would have placed >90% of the samples within the same concentration intervals using ranges of <0.05, 0.05-0.50, 0.50-5, and >5ng TEQ/g. Natural log transformed data for TOC had significantly weaker correlation to TEQ(D/F), indicating that TOC is not a reliable indicator of TEQ(D/F) concentrations.

[1]  Safe,et al.  Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. , 1998, Environmental health perspectives.

[2]  P. Haglund,et al.  Combined extraction / clean-up strategies for fast determination of PCDD/Fs and who-PCBs in food and feed samples using accelerated solvent extraction , 2003 .

[3]  C. Tohyama,et al.  The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[4]  R. Hites,et al.  Estimating the Atmospheric Deposition of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans from Soils. , 1995, Environmental science & technology.

[5]  M. Schrock,et al.  Simultaneous extraction of PCDD/PCDF and PCBs using accelerated solvent extraction for sediment, tissue and sludge matrices , 2003 .

[6]  C. D. De Rosa,et al.  Dioxin and Dioxin-Like Compounds in Soil, Part I: ATSDR Interim Policy Guideline , 1997, Toxicology and industrial health.

[7]  M. Gonnord,et al.  Improvements in GC/MS strategies and methodologies for PCDD and PCDF analysis , 1994 .

[8]  Hiroyasu Ito,et al.  Optimization of a method for determining dioxin in whole blood samples based on solvent extraction and simplified cleanup. , 2004, The Analyst.

[9]  E. Abad,et al.  Application of DB-5ms gas chromatography column for the complete assignment of 2,3,7,8-substituted polychlorodibenzo-p-dioxins and polychlorodibenzofurans in samples from municipal waste incinerator emissions , 1997 .

[10]  Helmut Greim,et al.  The international toxicity equivalency factor (I-TEF) method of risk assessment for complex mixtures of dioxins and related compounds , 1990 .