Form and function of retroviral proviruses.

Retroviruses have proved to be useful reagents for studying genetic and epigenetic (such as regulatory) changes in eukaryotic cells, for assessing functional and structural relationships between transposable genetic elements, for inducing insertional mutations, including some important in oncogenesis, and for transporting genes into eukaryotic cells, either after natural transduction of putative cellular oncogenes or after experimental construction of recombinant viruses. Many of these properties of retroviruses depend on their capacity to establish a DNA (proviral) form of their RNA genomes as a stable component of host chromosomes, in either somatic or germinal cells.

[1]  H. Varmus,et al.  Structure of a replication intermediate in the synthesis of Rous sarcoma virus DNA in vivo , 1982, Journal of virology.

[2]  P. Gruss,et al.  Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus , 1982, Nature.

[3]  H. Varmus,et al.  Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas , 1982, Nature.

[4]  D. Finnegan,et al.  Nucleotide sequence of terminal repeats of 412 transposable elements of Drosophila melanogaster. A similarity to proviral long terminal repeats and its implications for the mechanism of transposition. , 1981, Journal of molecular biology.

[5]  J. Banerji,et al.  Expression of a β-globin gene is enhanced by remote SV40 DNA sequences , 1981, Cell.

[6]  R. Weinberg,et al.  Proposal for Naming Host Cell-Derived Inserts in Retrovirus Genomes , 1981, Journal of virology.

[7]  P. Chambon,et al.  The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants. , 1981, Nucleic acids research.

[8]  R. Mulligan,et al.  Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids , 1981, Nature.

[9]  H. Varmus,et al.  Analysis of endogenous avian retrovirus DNA and RNA: viral and cellular determinants of retrovirus gene expression. , 1981, Virology.

[10]  H. Temin,et al.  Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus , 1981, Cell.

[11]  E. Scolnick,et al.  Generation of BALB-MuSV and Ha-MuSV by type C virus transduction of homologous transforming genes from different species , 1981, Cell.

[12]  N. Copeland,et al.  Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome , 1981, Nature.

[13]  E. Scolnick,et al.  Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1 , 1981, Journal of virology.

[14]  P. Neiman,et al.  Two distinct candidate transforming genes of lymphoid leukosis virus-induced neoplasms , 1981, Nature.

[15]  A. Flavell,et al.  Extrachromosomal circular copies of the eukaryotic transposable element copia in cultured Drosophila cells , 1981, Nature.

[16]  M. Groudine,et al.  Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation , 1981, Nature.

[17]  H. Varmus,et al.  A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[18]  H. Varmus,et al.  Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus , 1981, Cell.

[19]  S. Astrin,et al.  Chromosomal localization of three endogenous retrovirus loci associated with virus production in White Leghorn chickens , 1981, Journal of virology.

[20]  R. Jaenisch,et al.  Chromosomal position and activation of retroviral genomes inserted into the germ line of mice , 1981, Cell.

[21]  W. S. Hayward,et al.  Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis , 1981, Nature.

[22]  R. Weinberg,et al.  Generation of novel, biologically active Harvey sarcoma viruses via apparent illegitimate recombination , 1981, Journal of virology.

[23]  Pierre Chambon,et al.  In vivo sequence requirements of the SV40 early promoter region , 1981, Nature.

[24]  P. Gruss,et al.  Simian virus 40 tandem repeated sequences as an element of the early promoter. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[25]  G. Cooper,et al.  Transforming activity of human tumor DNAs. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[26]  H. Varmus,et al.  Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state , 1981, Cell.

[27]  W. S. Hayward,et al.  Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion , 1981, Cell.

[28]  J. Bishop.  Enemies within: the genesis of retrovirus oncogenes , 1981, Cell.

[29]  S. Astrin,et al.  Nucleotide sequence of acceptor site and termini of integrated avian endogenous provirus ev1: Integration creates a 6 bp repeat of host DNA , 1981, Cell.

[30]  H. Varmus,et al.  Nucleotide sequences at host–proviral junctions for mouse mammary tumour virus , 1981, Nature.

[31]  H. Varmus,et al.  The structure and protein kinase activity of proteins encoded by nonconditional mutants and back mutants in the sec gene of avian sarcoma virus. , 1981, Virology.

[32]  H. Varmus,et al.  Organization of the endogenous proviruses of chickens: implications for origin and expression. , 1981, Virology.

[33]  H. Varmus,et al.  Revertants of an ASV-transformed rat cell line have lost the complete provius or sustained mutations in src. , 1981, Virology.

[34]  H. Varmus,et al.  Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[35]  P Chambon,et al.  Organization and expression of eucaryotic split genes coding for proteins. , 1981, Annual review of biochemistry.

[36]  B. Nadal-Ginard,et al.  Moloney murine sarcoma proviral DNA is a transcriptional unit , 1980, Nature.

[37]  H. Temin,et al.  No apparent nucleotide sequence specificity in cellular DNA juxtaposed to retrovirus proviruses. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[38]  H. Varmus,et al.  Structure of viral DNA and RNA in mammalian cells infected with avian sarcoma virus. , 1980, Journal of molecular biology.

[39]  A. Riggs,et al.  DNA methylation and gene function. , 1980, Science.

[40]  M. Linial,et al.  Avian oncovirus mutant (SE21Q1b) deficient in genomic RNA: characterization of a deletion in the provirus , 1980, Journal of virology.

[41]  Mario R. Capecchi,et al.  High efficiency transformation by direct microinjection of DNA into cultured mammalian cells , 1980, Cell.

[42]  J. Stephenson,et al.  Homology exists among the transforming sequences of avian and feline sarcoma viruses. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[43]  P. Neiman,et al.  Transforming genes of neoplasms induced by avian lymphoid leukosis viruses , 1980, Nature.

[44]  H. Temin.  Origin of retroviruses from cellular moveable genetic elements , 1980, Cell.

[45]  C. Kozak,et al.  Germ-line reinsertions of AKR murine leukemia virus genomes in Akv-1 congenic mice. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[46]  L. Enquist,et al.  Nucleotide sequences of integrated Moloney sarcoma provirus long terminal repeats and their host and viral junctions. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[47]  S. Mizutani,et al.  Sequence of retrovirus provirus resembles that of bacterial transposable elements , 1980, Nature.

[48]  R. Lerner,et al.  Nucleotide sequence of Moloney leukemia virus: 3' end reveals details of replications, analogy to bacterial transposons, and an unexpected gene. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[49]  G. Cooper,et al.  Transforming activity of DNA of chemically transformed and normal cells , 1980, Nature.

[50]  J. Maizel,et al.  Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus. , 1980, Science.

[51]  J. Taylor,et al.  Reverse transcription of avian sarcoma virus RNA into DNA might involve copying of the tRNA primer , 1980, Journal of virology.

[52]  R. Weinberg.  Integrated genomes of animal viruses. , 1980, Annual review of biochemistry.

[53]  R. Weiss,et al.  Differences between the endogenous and exogenous dna sequences of rous-associated virus-O , 1979, Cell.

[54]  R. Weinberg,et al.  Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[55]  H. Varmus,et al.  Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases , 1979, Cell.

[56]  David Baltimore,et al.  A detailed model of reverse transcription and tests of crucial aspects , 1979, Cell.

[57]  M. Roussel,et al.  The distribution of endogenous chicken retrovirus sequences in the DNA of galliform birds does not coincide with avian phylogenetic relationships , 1979, Cell.

[58]  Tom Maniatis,et al.  Transformation of mammalian cells with genes from procaryotes and eucaryotes , 1979, Cell.

[59]  J. Shapiro.  Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[60]  H. Varmus,et al.  Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding , 1979, Nature.

[61]  K. Yamamoto,et al.  Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[62]  R. Weinberg,et al.  Restriction endonuclease cleavage of linear and closed circular murine leukemia viral DNAS: Discovery of a smaller circular form , 1979, Cell.

[63]  H. Varmus,et al.  Endogenous mouse mammary tumor virus DNA is distributed among multiple mouse chromosomes. , 1979, Virology.

[64]  J. Coffin.  Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses. , 1979, The Journal of general virology.

[65]  H. Varmus,et al.  Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites , 1978, Cell.

[66]  J. Taylor,et al.  Analysis of unintegrated avian RNA tumor virus double-stranded DNA intermediates , 1978, Journal of virology.

[67]  H. Varmus,et al.  Mapping unintegrated avian sarcoma virus DNA: Termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA , 1978, Cell.

[68]  S. Astrin.  Endogenous viral genes of the White Leghorn chicken: common site of residence and sites associated with specific phenotypes of viral gene expression. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[69]  R. Weinberg,et al.  The integrated genome of murine leukemia virus , 1978, Cell.

[70]  K. Yamamoto,et al.  Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[71]  K. Yamamoto,et al.  Production of unintegrated mouse mammary tumor virus DNA in infected rat hepatoma cells is a secondary action of dexamethasone , 1978, Journal of virology.

[72]  K. Yamamoto,et al.  Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[73]  H. Varmus,et al.  Chicken macrochromosomes contain an endogenous provirus and microchromosomes contain sequences related to the transforming gene of ASV , 1977, Cell.

[74]  J. Taylor.  An analysis of the role of tRNA species as primers for the transcription into DNA of RNA tumor virus genomes. , 1977, Biochimica et biophysica acta.

[75]  E. Scolnick,et al.  Steroid induction of mouse mammary tumor virus: effect upon synthesis and degradation of viral RNA , 1977, Journal of virology.

[76]  M. Groudine,et al.  Chromosomal subunits in active genes have an altered conformation. , 1976, Science.

[77]  W. S. Hayward,et al.  Independent regulation of endogenous and exogenous avian RNA tumor virus genes. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[78]  H. Varmus,et al.  Unintegrated viral DNA is synthesized in the cytoplasm of avian sarcoma virus-transformed duck cells by viral DNA polymerase , 1976, Journal of virology.

[79]  H. Varmus,et al.  DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA , 1976, Nature.

[80]  B. Alberts,et al.  Steroid receptors: elements for modulation of eukaryotic transcription. , 1976, Annual review of biochemistry.

[81]  H. Varmus,et al.  The persistence and expression of virus-specific DNA in revertants of Rous sarcoma virus-transformed BHK-21 cells. , 1974, Virology.

[82]  D. Boettiger.  Reversion and induction of Rous sarcoma virus expression in virus-transformed baby hamster kidney cells. , 1974, Virology.

[83]  N. Proudfoot,et al.  Sequence at the 3′ end of globin mRNA shows homology with immunoglobulin light chain mRNA , 1974, Nature.

[84]  M. Jacquet,et al.  The in vitro synthesis of avian myeloblastosis viral RNA sequences. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[85]  J. Parsons,et al.  In vitro synthesis of Rous sarcoma virus-specific RNA is catalyzed by a DNA-dependent RNA polymerase. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[86]  R. Huebner,et al.  The Viral Oncogene Hypothesis: New Evidence , 1972 .