Achieving Continuous Manufacturing : Technologies and Approaches for Synthesis , Work-Up and Isolation of Drug Substance

Introduction the Future for Continuous Drug Substance Manufacture Successful innovation in manufacturing and adoption of continuous manufacturing (CM) has an important role to play in the industry’s future (ref Badman and Trout, 2014). The vision for CM in the pharmaceutical industry is to exploit integrated end-to-end processing to convert raw materials into safe, effective and high quality medicinal products. This vision is driven by the potential to improve control over quality, reduce costs, enhance process safety and significantly reduce the timelines currently involved across the medicines’ supply chain. As new continuous systems and technologies become fully established, so the industry’s ability to continue to meet the demands for existing as well as new, safer and increasingly personalized dosage forms will be enhanced.