Polyethylene Glycol and Polyethylene Glycol/Hydroxyapatite Constructs Produced through Stereo-Thermal Lithography

Stereo-thermal lithography (STLG) is an innovative system that uses ultraviolet (UV) radiation and near-infrared (IR) radiation simultaneously to initiate the curing reaction in a liquid solution, containing both UV and IR photoinitiator. In this research work, poly (ethylene glycol) dimethacrylate (PEGDMA) and PEGDMA/hydroxyapatite (HA) constructs were produced using the STLG system, operating in the UV mode, and characterised regarding the morphology and water absorption properties. Constructs were produced with different geometries and shapes by introducing several variations in the processing parameters, such as the irradiation time and the layer thickness. Results show the ability of the system to produce constructs at the micro-scale with very good definition and resolution. The irradiation time is the critical processing parameter, strongly affecting the water absorption and the structural integrity of the constructs.

[1]  Paulo Jorge Da Silva bartolo,et al.  Photo-curing modelling: direct irradiation , 2007 .

[2]  J. Ciurana,et al.  Biomedical production of implants by additive electro-chemical and physical processes , 2012 .

[3]  Rashid Bashir,et al.  Stereolithography‐Based Hydrogel Microenvironments to Examine Cellular Interactions , 2011 .

[4]  Geoffrey R. Mitchell,et al.  Stereo‐thermal‐lithography: a new principle for rapid prototyping , 2003 .

[5]  Paulo Jorge Da Silva Bartolo,et al.  Modeling and simulation of photofabrication processes using unsaturated polyester resins , 2009 .

[6]  P. Bártolo,et al.  Additive manufacturing of tissues and organs , 2012 .

[7]  F. Melchels,et al.  A review on stereolithography and its applications in biomedical engineering. , 2010, Biomaterials.

[8]  Paulo Jorge Da Silva bartolo,et al.  Biofabrication Strategies for Tissue Engineering , 2011 .

[9]  Jan Feijen,et al.  Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[10]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[11]  Rashid Bashir,et al.  Three-dimensional photopatterning of hydrogels using stereolithography for long-term cell encapsulation. , 2010, Lab on a chip.

[12]  Jan Feijen,et al.  A poly(D,L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography. , 2009, Biomaterials.