Chondrocyte Deformations Under Mild Dynamic Loading Conditions

[1]  W. Herzog,et al.  Effect of strain rate on transient local strain variations in articular cartilage. , 2019, Journal of the mechanical behavior of biomedical materials.

[2]  A. Hall The Role of Chondrocyte Morphology and Volume in Controlling Phenotype—Implications for Osteoarthritis, Cartilage Repair, and Cartilage Engineering , 2019, Current Rheumatology Reports.

[3]  W. Herzog,et al.  Effects of macro-cracks on the load bearing capacity of articular cartilage , 2019, Biomechanics and Modeling in Mechanobiology.

[4]  W. Herzog,et al.  A compression system for studying depth-dependent mechanical properties of articular cartilage under dynamic loading conditions. , 2018, Medical engineering & physics.

[5]  W. Herzog,et al.  Alterations in structural macromolecules and chondrocyte deformations in lapine retropatellar cartilage 9 weeks after anterior cruciate ligament transection , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[6]  W. Herzog,et al.  Unfolding of membrane ruffles of in situ chondrocytes under compressive loads , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[7]  Xin Zhang,et al.  Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression , 2016, Scientific Reports.

[8]  Scott C. Sibole,et al.  pyCellAnalyst: Extensive Software for Three-dimensional Analysis of Deforming Cells , 2016 .

[9]  W. Herzog,et al.  Site-dependent biomechanical responses of chondrocytes in the rabbit knee joint. , 2015, Journal of biomechanics.

[10]  F. Guilak,et al.  TRPV4 as a therapeutic target for joint diseases , 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

[11]  G. Brüggemann,et al.  Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review , 2015, PloS one.

[12]  S. Jyothi,et al.  A Survey on Threshold Based Segmentation Technique in Image Processing , 2014 .

[13]  Alfio Grillo,et al.  Poroelastic materials reinforced by statistically oriented fibres—numerical implementation and application to articular cartilage , 2014 .

[14]  Farshid Guilak,et al.  The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis , 2014, Current Rheumatology Reports.

[15]  D. Hukins,et al.  Viscoelastic properties of bovine knee joint articular cartilage: dependency on thickness and loading frequency , 2014, BMC Musculoskeletal Disorders.

[16]  W. Herzog,et al.  The effect of compressive loading magnitude on in situ chondrocyte calcium signaling , 2014, Biomechanics and modeling in mechanobiology.

[17]  Keita Ito,et al.  Deformation thresholds for chondrocyte death and the protective effect of the pericellular matrix. , 2014, Tissue engineering. Part A.

[18]  Noor Azuan Abu Osman,et al.  Dual photon excitation microscopy and image threshold segmentation in live cell imaging during compression testing. , 2013, Journal of biomechanics.

[19]  P. Mente,et al.  Changes in chondrocyte gene expression following in vitro impaction of porcine articular cartilage in an impact injury model , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[20]  W. Herzog,et al.  Chondrocyte deformation under extreme tissue strain in two regions of the rabbit knee joint. , 2013, Journal of biomechanics.

[21]  Scott C. Sibole,et al.  Chondrocyte Deformations as a Function of Tibiofemoral Joint Loading Predicted by a Generalized High-Throughput Pipeline of Multi-Scale Simulations , 2012, PloS one.

[22]  H. Sun,et al.  Mechanotransduction and cartilage integrity , 2011, Annals of the New York Academy of Sciences.

[23]  Eun Sun Kim,et al.  Multiphoton microscopy: an introduction to gastroenterologists. , 2011, World journal of gastroenterology.

[24]  W Herzog,et al.  A novel method for determining articular cartilage chondrocyte mechanics in vivo. , 2011, Journal of biomechanics.

[25]  Walter Herzog,et al.  Mechanical loading of in situ chondrocytes in lapine retropatellar cartilage after anterior cruciate ligament transection , 2010, Journal of The Royal Society Interface.

[26]  Harry E Rubash,et al.  In vivo tibiofemoral cartilage deformation during the stance phase of gait. , 2010, Journal of biomechanics.

[27]  Frederick Sachs,et al.  Stretch-activated ion channels: what are they? , 2010, Physiology.

[28]  Walter Herzog,et al.  Confocal microscopy indentation system for studying in situ chondrocyte mechanics. , 2009, Medical engineering & physics.

[29]  G. Ateshian,et al.  Duty Cycle of Deformational Loading Influences the Growth of Engineered Articular Cartilage , 2009, Cellular and Molecular Bioengineering.

[30]  D. Salter,et al.  Signalling cascades in mechanotransduction: cell–matrix interactions and mechanical loading , 2009, Scandinavian journal of medicine & science in sports.

[31]  D. Hukins,et al.  Viscoelastic properties of bovine articular cartilage attached to subchondral bone at high frequencies , 2009, BMC musculoskeletal disorders.

[32]  A. Thambyah,et al.  On how degeneration influences load-bearing in the cartilage-bone system: a microstructural and micromechanical study. , 2007, Osteoarthritis and cartilage.

[33]  F. Guilak,et al.  Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy. , 2006, Osteoarthritis and cartilage.

[34]  Jon D. Szafranski,et al.  Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis. , 2004, Osteoarthritis and cartilage.

[35]  Moonsoo Jin,et al.  Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. , 2004, Journal of biomechanics.

[36]  R. G. Richards,et al.  Deformation of Chondrocytes in Articular Cartilage under Compressive Load: A Morphological Study , 2003, Cells Tissues Organs.

[37]  A. Braccini,et al.  Dynamic compression of cartilage constructs engineered from expanded human articular chondrocytes. , 2003, Biochemical and biophysical research communications.

[38]  Gerard A Ateshian,et al.  Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering. , 2003, Tissue engineering.

[39]  A. Hall,et al.  The volume and morphology of chondrocytes within non-degenerate and degenerate human articular cartilage. , 2003, Osteoarthritis and cartilage.

[40]  Gerard A. Ateshian,et al.  Influence of Seeding Density and Dynamic Deformational Loading on the Developing Structure/Function Relationships of Chondrocyte-Seeded Agarose Hydrogels , 2002, Annals of Biomedical Engineering.

[41]  Albert C. Chen,et al.  Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[42]  R. Schneiderman,et al.  Depth-dependent compressive properties of normal aged human femoral head articular cartilage: relationship to fixed charge density. , 2001, Osteoarthritis and cartilage.

[43]  F Guilak,et al.  Viscoelastic properties of chondrocytes from normal and osteoarthritic human cartilage , 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[44]  G A Ateshian,et al.  Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. , 2000, Journal of biomechanical engineering.

[45]  M. Wong,et al.  Cyclic compression of articular cartilage explants is associated with progressive consolidation and altered expression pattern of extracellular matrix proteins. , 1999, Matrix biology : journal of the International Society for Matrix Biology.

[46]  D L Bader,et al.  Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression. , 1998, Medical engineering & physics.

[47]  Albert C. Chen,et al.  Depth‐dependent confined compression modulus of full‐thickness bovine articular cartilage , 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[48]  P. Eggli,et al.  Chondrocyte biosynthesis correlates with local tissue strain in statically compressed adult articular cartilage , 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[49]  F. Guilak Compression-induced changes in the shape and volume of the chondrocyte nucleus. , 1995, Journal of biomechanics.

[50]  A Ratcliffe,et al.  Changes in proteoglycan synthesis of chondrocytes in articular cartilage are associated with the time-dependent changes in their mechanical environment. , 1995, Journal of biomechanics.

[51]  V. Mow,et al.  Chondrocyte deformation and local tissue strain in articular cartilage: A confocal microscopy study , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[52]  T. Andriacchi,et al.  Chondrocyte cells respond mechanically to compressive loads , 1994, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[53]  F Guilak,et al.  Volume and surface area measurement of viable chondrocytes in situ using geometric modelling of serial confocal sections , 1994, Journal of microscopy.

[54]  A. Grodzinsky,et al.  Biosynthetic response of cartilage explants to dynamic compression , 1989, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[55]  A. Maroudas,et al.  Structure of proteoglycans from different layers of human articular cartilage. , 1983, The Biochemical journal.

[56]  V. Mow,et al.  Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiments. , 1980, Journal of biomechanical engineering.

[57]  A. Maroudas,et al.  Balance between swelling pressure and collagen tension in normal and degenerate cartilage , 1976, Nature.

[58]  P. Bullough,et al.  Permeability of articular cartilage. , 1968, Nature.

[59]  Alfio Grillo,et al.  Elasticity and permeability of porous fibre-reinforced materials under large deformations , 2012 .

[60]  Walter Herzog,et al.  Depth-dependent analysis of the role of collagen fibrils, fixed charges and fluid in the pericellular matrix of articular cartilage on chondrocyte mechanics. , 2008, Journal of biomechanics.

[61]  Farshid Guilak,et al.  Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. , 2007, Journal of biomechanics.

[62]  G A Ateshian,et al.  Mechanical response of bovine articular cartilage under dynamic unconfined compression loading at physiological stress levels. , 2004, Osteoarthritis and cartilage.

[63]  J. Berg,et al.  Cells Can Respond to Changes in Their Environments , 2002 .

[64]  Albert C. Chen,et al.  Depth- and strain-dependent mechanical and electromechanical properties of full-thickness bovine articular cartilage in confined compression. , 2001, Journal of biomechanics.

[65]  John F. Bolton,et al.  Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels. , 2000, Journal of biomechanics.

[66]  V. Mow,et al.  Deformation of Chondrocytes within the Extracellular Matrix of Articular Cartilage , 1993 .

[67]  A. Ben-Ze'ev Animal cell shape changes and gene expression. , 1991, BioEssays : news and reviews in molecular, cellular and developmental biology.