Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site*
暂无分享,去创建一个
[1] A. Newton,et al. The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation , 1999, Current Biology.
[2] S. Schreiber,et al. Kinase phosphorylation: Keeping it all in the family , 1999, Current Biology.
[3] A. Casamayor,et al. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2 , 1999, Current Biology.
[4] Julian Downward,et al. Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell–matrix and cell–cell interaction , 1999, Current Biology.
[5] B. Hemmings,et al. A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain* , 1999, The Journal of Biological Chemistry.
[6] A. Newton,et al. Carboxyl-terminal Phosphorylation Regulates the Function and Subcellular Localization of Protein Kinase C βII* , 1999, The Journal of Biological Chemistry.
[7] A. Newton,et al. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) , 1998, Current Biology.
[8] A. Newton,et al. Regulation of protein kinase C ζ by PI 3-kinase and PDK-1 , 1998, Current Biology.
[9] J. Sweatt,et al. Protected‐Site Phosphorylation of Protein Kinase C in Hippocampal Long‐Term Potentiation , 1998, Journal of neurochemistry.
[10] Frank McCormick,et al. Akt activation by growth factors is a multiple-step process: the role of the PH domain , 1998, Oncogene.
[11] J. Downward. Mechanisms and consequences of activation of protein kinase B/Akt. , 1998, Current opinion in cell biology.
[12] P. Cohen,et al. Mechanism of activation and function of protein kinase B. , 1998, Current opinion in genetics & development.
[13] F. McCormick,et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. , 1998, Science.
[14] P. Cohen,et al. Role of Translocation in the Activation and Function of Protein Kinase B* , 1997, The Journal of Biological Chemistry.
[15] F. McCormick,et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. , 1997, Science.
[16] A. Newton,et al. Regulation of protein kinase C. , 1997, Current opinion in cell biology.
[17] P. Cohen,et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα , 1997, Current Biology.
[18] M. Andjelkovic,et al. High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity* , 1997, The Journal of Biological Chemistry.
[19] David R. Kaplan,et al. Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate , 1997, Science.
[20] D. Pot,et al. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain , 1997, Molecular and cellular biology.
[21] P. Cohen,et al. Mechanism of activation of protein kinase B by insulin and IGF‐1. , 1996, The EMBO journal.
[22] D. Alessi,et al. Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. , 1996, The Biochemical journal.
[23] A. Newton,et al. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations , 1995, Current Biology.
[24] R. Pearson,et al. The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. , 1995, The EMBO journal.
[25] Andrius Kazlauskas,et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase , 1995, Cell.
[26] J. Blenis,et al. The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. , 1995, Current opinion in cell biology.
[27] Susan S. Taylor,et al. Three protein kinase structures define a common motif. , 1994, Structure.
[28] J. Testa,et al. Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. , 1993, Oncogene.
[29] J. Cheng,et al. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[30] A. Newton,et al. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. , 1992, The Journal of biological chemistry.
[31] M. Siegmann,et al. Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[32] Y. Nishizuka,et al. Cloning of rat brain protein kinase C complementary DNA , 1986, FEBS letters.
[33] E. Krebs,et al. Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. , 1986, Proceedings of the National Academy of Sciences of the United States of America.