A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research

Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better devise strategies for the prevention of asthma. The U.S. Environmental Protection Agency (EPA) and National Institute of Environmental Health Sciences held a conference in October 2004 to collaboratively discuss a future research agenda in this area. The first three articles in this mini-monograph summarize the discussion on potential putative environmental exposure; they include an overview of asthma and conclusions of the workshop participants with respect to public health actions that could currently be applied to the problem and research needs to better understand and control the induction and incidence of asthma, the potential role of indoor/outdoor air pollutants in the induction of asthma), and biologics in the induction of asthma. Susceptibility is a key concept in the U.S. EPA “Asthma Research Strategy” document and is associated with the U.S. EPA framework of protecting vulnerable populations from potentially harmful environmental exposures. Genetics, age, and lifestyle (obesity, diet) are major susceptibility factors in the induction of asthma and can interact with environmental exposures either synergistically or antagonistically. Therefore, in this fourth and last article we consider a number of “susceptibility factors” that potentially influence the asthmatic response to environmental exposures and propose a framework for developing research hypotheses regarding the effects of environmental exposures on asthma incidence and induction.

[1]  Andre E. Nel,et al.  How Exposure to Environmental Tobacco Smoke, Outdoor Air Pollutants, and Increased Pollen Burdens Influences the Incidence of Asthma , 2006, Environmental health perspectives.

[2]  M. Chapman,et al.  How Exposures to Biologics Influence the Induction and Incidence of Asthma , 2006, Environmental health perspectives.

[3]  Philip A. Bromberg,et al.  Induction of Asthma and the Environment: What We Know and Need to Know , 2006, Environmental health perspectives.

[4]  M. Yazdanbakhsh,et al.  The role of helminth infections in protection from atopic disorders , 2005, Current opinion in allergy and clinical immunology.

[5]  D. Nowak,et al.  Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environments. , 2005, The Journal of allergy and clinical immunology.

[6]  D. Loomis,et al.  Progression of self-reported symptoms in laboratory animal allergy. , 2005, The Journal of allergy and clinical immunology.

[7]  P. Sly,et al.  Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies. , 2005, The Journal of allergy and clinical immunology.

[8]  D. Gold,et al.  Immigration to the United States and acculturation as risk factors for asthma and allergy. , 2005, The Journal of allergy and clinical immunology.

[9]  L. Portengen,et al.  Endotoxin exposure and atopic sensitization in adult pig farmers. , 2005, The Journal of allergy and clinical immunology.

[10]  R. Poulton,et al.  Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. , 2005, American journal of respiratory and critical care medicine.

[11]  Jean M. Cox-Ganser,et al.  Respiratory Morbidity in Office Workers in a Water-Damaged Building , 2005, Environmental health perspectives.

[12]  D. Strachan,et al.  Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[13]  A. Imrich,et al.  Effect of leptin on allergic airway responses in mice. , 2005, The Journal of allergy and clinical immunology.

[14]  Rosalind Wright,et al.  Population disparities in asthma. , 2005, Annual review of public health.

[15]  W. Cookson.  The immunogenetics of asthma and eczema: a new focus on the epithelium , 2004, Nature Reviews Immunology.

[16]  J. Douwes,et al.  Can bacterial endotoxin exposure reverse atopy and atopic disease? , 2004, The Journal of allergy and clinical immunology.

[17]  K. Kreiss,et al.  Building-related respiratory symptoms can be predicted with semi-quantitative indices of exposure to dampness and mold. , 2004, Indoor air.

[18]  M. Moffatt,et al.  Making sense of asthma genes. , 2004, The New England journal of medicine.

[19]  Disease Prevention,et al.  Damp Indoor Spaces and Health , 2004 .

[20]  D. Grobbee,et al.  A strategy for health surveillance in laboratory animal workers exposed to high molecular weight allergens , 2004, Occupational and Environmental Medicine.

[21]  P. Sly,et al.  Functional Maturation of CD4+CD25+CTLA4+CD45RA+ T Regulatory Cells in Human Neonatal T Cell Responses to Environmental Antigens/Allergens1 , 2004, The Journal of Immunology.

[22]  S. Bonini,et al.  Dampness in buildings as a risk factor for health effects, EUROEXPO: a multidisciplinary review of the literature (1998-2000) on dampness and mite exposure in buildings and health effects. , 2004, Indoor air.

[23]  F. Darendeliler,et al.  Leptin: does it have any role in childhood asthma? , 2004, Journal of Allergy and Clinical Immunology.

[24]  S. Guerra,et al.  Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty. , 2004, American journal of respiratory and critical care medicine.

[25]  J. Fredberg,et al.  Differential effects of ozone on airway and tissue mechanics in obese mice. , 2004, Journal of applied physiology.

[26]  S. Aaron,et al.  Effect of weight reduction on respiratory function and airway reactivity in obese women. , 2004, Chest.

[27]  D. Mannino,et al.  Risk factors for asthma incidence : a review of recent prospective evidence , 2016 .

[28]  J. Schouten,et al.  Determinants of maximally attained level of pulmonary function. , 2004, American journal of respiratory and critical care medicine.

[29]  C. Rand,et al.  Guidelines for assessing and managing asthma risk at work, school, and recreation. , 2004, American journal of respiratory and critical care medicine.

[30]  D. Nowak,et al.  Toll-like receptor 2 as a major gene for asthma in children of European farmers. , 2004, The Journal of allergy and clinical immunology.

[31]  H. Wichmann,et al.  Mode of delivery and development of atopic disease during the first 2 years of life , 2004, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[32]  M. Tanimoto,et al.  Influence of long‐term cigarette smoking on immunoglobulin E‐mediated allergy, pulmonary function, and high‐resolution computed tomography lung densitometry in elderly patients with asthma , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[33]  Mika Gissler,et al.  Maternal smoking in pregnancy, fetal development, and childhood asthma. , 2004, American journal of public health.

[34]  R. Ehrlich,et al.  Body mass index and the risk of asthma in adults. , 2004, Respiratory medicine.

[35]  Dan Nicolae,et al.  Association studies for asthma and atopic diseases: a comprehensive review of the literature , 2003, Respiratory research.

[36]  D. Dockery,et al.  Body‐mass index as a predictor of incident asthma in a prospective cohort of children , 2003, Pediatric pulmonology.

[37]  P. Holt,et al.  Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. , 2003, The Journal of allergy and clinical immunology.

[38]  C. Salome,et al.  Asthma and atopy in overweight children , 2003, Thorax.

[39]  H. Kotani,et al.  Adiposity Elevates Plasma MCP-1 Levels Leading to the Increased CD11b-positive Monocytes in Mice* , 2003, Journal of Biological Chemistry.

[40]  P. Cullinan,et al.  The prevention of occupational asthma , 2003, European Respiratory Journal.

[41]  Martin J Firth,et al.  Association between antenatal cytokine production and the development of atopy and asthma at age 6 years , 2003, The Lancet.

[42]  Phil A. Silva,et al.  A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. , 2003, The New England journal of medicine.

[43]  S. Tortolero,et al.  Occupational exposures associated with work-related asthma and work-related wheezing among U.S. workers. , 2003, American journal of industrial medicine.

[44]  Richard J Jackson,et al.  The impact of the built environment on health: an emerging field. , 2003, American journal of public health.

[45]  C. Janson,et al.  The prevalence and predictors of respiratory-related work limitation and occupational disability in an international study. , 2003, Chest.

[46]  Carlos A Camargo,et al.  Body mass index and asthma severity among adults presenting to the emergency department. , 2003, Chest.

[47]  S. Shore,et al.  Responses to ozone are increased in obese mice. , 2003, Journal of applied physiology.

[48]  S. London,et al.  Animal production and wheeze in the Agricultural Health Study: interactions with atopy, asthma, and smoking , 2003, Occupational and environmental medicine.

[49]  D. Strachan,et al.  Neonatal head circumference, neonatal weight, and risk of hayfever, asthma and eczema in a large cohort of adolescents from Sheffield, England , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[50]  S. Tortolero,et al.  Prevalence and risk factors of asthma and wheezing among US adults: an analysis of the NHANES III data , 2003, European Respiratory Journal.

[51]  P. Garcia-Lorda,et al.  Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. , 2003, Obesity research.

[52]  J. Malo,et al.  Time course of onset of sensitization to common and occupational inhalants in apprentices. , 2003, The Journal of allergy and clinical immunology.

[53]  F. Rengo,et al.  Aging and disability affect misdiagnosis of COPD in elderly asthmatics: the SARA study. , 2003, Chest.

[54]  P. McKeigue,et al.  For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group. Problems of Reporting Genetic Associations with Complex Outcomes , 2022 .

[55]  Kathleen Kreiss,et al.  American Thoracic Society Statement: Occupational contribution to the burden of airway disease. , 2003, American journal of respiratory and critical care medicine.

[56]  M. Chan-yeung,et al.  Proceedings of the first Jack Pepys Occupational Asthma Symposium. , 2003, American journal of respiratory and critical care medicine.

[57]  S. Chinn.  Obesity and Asthma: Evidence For and Against a Causal Relation , 2003, The Journal of asthma : official journal of the Association for the Care of Asthma.

[58]  V. Mishra.  Effect of indoor air pollution from biomass combustion on prevalence of asthma in the elderly. , 2002, Environmental health perspectives.

[59]  R. Kakuma,et al.  Maternal dietary antigen avoidance during pregnancy and/or lactation for preventing or treating atopic disease in the child. , 2003, The Cochrane database of systematic reviews.

[60]  D. Nowak,et al.  Environmental exposure to endotoxin and its relation to asthma in school-age children. , 2002, The New England journal of medicine.

[61]  R. Hubbard,et al.  The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands General Practice Database. , 2002, American journal of respiratory and critical care medicine.

[62]  F. Martinez,et al.  What have we learned from the Tucson Children's Respiratory Study? , 2002, Paediatric respiratory reviews.

[63]  D. Mannino,et al.  Chronic obstructive pulmonary disease surveillance--United States, 1971-2000. , 2002, Respiratory care.

[64]  C. Skudlik,et al.  Primary prevention of natural rubber latex allergy in the German health care system through education and intervention. , 2002, The Journal of allergy and clinical immunology.

[65]  D. Weissman,et al.  Allergic and latex-specific sensitization: route, frequency, and amount of exposure that are required to initiate IgE production. , 2002, The Journal of allergy and clinical immunology.

[66]  J. Douwes,et al.  Non-eosinophilic asthma: importance and possible mechanisms , 2002, Thorax.

[67]  M. Jaakkola,et al.  Indoor dampness and molds and development of adult-onset asthma: a population-based incident case-control study. , 2002, Environmental health perspectives.

[68]  I. Annesi-Maesano,et al.  Early life factors related to clinical manifestations of atopic disease but not to skin‐prick test positivity in young children , 2002, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[69]  D. Mannino,et al.  Surveillance for asthma--United States, 1980-1999. , 2002, Morbidity and mortality weekly report. Surveillance summaries.

[70]  K. Berhane,et al.  Asthma in exercising children exposed to ozone: a cohort study , 2002, The Lancet.

[71]  R. Pierce,et al.  Prenatal nicotine exposure and abnormal lung function. , 2002, American journal of respiratory cell and molecular biology.

[72]  H. Sekhon,et al.  Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors. , 2002, American journal of respiratory cell and molecular biology.

[73]  G. Liss,et al.  Natural rubber latex-related occupational asthma: association with interventions and glove changes over time. , 2001, American journal of industrial medicine.

[74]  N. Benowitz,et al.  Prenatal nicotine exposure alters pulmonary function in newborn rhesus monkeys. , 2001, American journal of respiratory and critical care medicine.

[75]  K. Kurppa,et al.  Work is related to a substantial portion of adult-onset asthma incidence in the Finnish population. , 2001, American journal of respiratory and critical care medicine.

[76]  Mark C. Swanson,et al.  Clearing the Air: Asthma and Indoor Air Exposures , 2001 .

[77]  S. Holgate,et al.  Prevalence of untreated asthma in a population sample of 6000 older adults in Bristol, UK , 2001, Thorax.

[78]  J. Castro‐Rodriguez,et al.  Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. , 2001, American journal of respiratory and critical care medicine.

[79]  P. Naumann,et al.  Asthma severity, atopic status, allergen exposure and quality of life in elderly persons. , 2001, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[80]  F. Martinez,et al.  Interactions between genes and environment in the development
of asthma , 2001, Allergy.

[81]  K. Torén,et al.  Adult‐onset asthma is associated with self‐reported mold or environmental tobacco smoke exposures in the home , 2001, Allergy.

[82]  M. Schweigert,et al.  Occupational asthma and allergy associated with the use of enzymes in the detergent industry–a review of the epidemiology, toxicology and methods of prevention , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[83]  Braun‐Fahrländer,et al.  Exposure to endotoxin or other bacterial components might protect against the development of atopy , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[84]  J. Castro‐Rodriguez,et al.  Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. , 2000, The New England journal of medicine.

[85]  D. Strachan.  Family size, infection and atopy: the first decade of the 'hygiene hypothesis' , 2000, Thorax.

[86]  Lewis Dm,et al.  Is specific antibody determination diagnostic for asthma attributable to low-molecular-weight agents? , 2000 .

[87]  T. Poussa,et al.  Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study , 2000, BMJ : British Medical Journal.

[88]  H. Navarro,et al.  Gestational nicotine exposure alone or in combination with ethanol down-modulates offspring immune function. , 2000, International journal of immunopharmacology.

[89]  D. Weissman,et al.  Is specific antibody determination diagnostic for asthma attributable to low-molecular-weight agents? , 2000, Occupational Medicine.

[90]  A. Kalache,et al.  The greying world: a challenge for the twenty-first century. , 2000, Science progress.

[91]  P. Sly,et al.  The role of allergy in the development of asthma , 1999, Nature.

[92]  W. Willett,et al.  Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. , 1999, Archives of internal medicine.

[93]  D. Golenbock,et al.  Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products* , 1999, The Journal of Biological Chemistry.

[94]  C. Pollack.  Underdiagnosis and Undertreatment of Asthma in the Elderly , 1999 .

[95]  P. Burton,et al.  Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study , 1999, BMJ.

[96]  N. Pearce,et al.  The magnitude of the effect of smaller family sizes on the increase in the prevalence of asthma and hay fever in the United Kingdom and New Zealand. , 1999, The Journal of allergy and clinical immunology.

[97]  P. Enright,et al.  Underdiagnosis and undertreatment of asthma in the elderly. Cardiovascular Health Study Research Group. , 1999, Chest.

[98]  P. Sly,et al.  Control of breathing in infants born to smoking mothers. , 1999, The Journal of pediatrics.

[99]  Huang,et al.  Association between body mass index and allergy in teenage girls in Taiwan , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[100]  P. Sly,et al.  Development of allergen-specific T-cell memory in atopic and normal children , 1999, The Lancet.

[101]  Prescott,et al.  Reciprocal age‐related patterns of allergen‐specific T‐cell immunity in normal vs. atopic infants , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[102]  S. Weiss,et al.  Indoor allergens and longitudinal FEV1 decline in older adults: the Normative Aging Study. , 1998, The Journal of allergy and clinical immunology.

[103]  F. Forastiere,et al.  Occupation, asthma, and chronic respiratory symptoms in a community sample of older women. , 1998, American journal of respiratory and critical care medicine.

[104]  E. Luder,et al.  Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. , 1998, The Journal of pediatrics.

[105]  A. Hildreth,et al.  Asthma in the elderly: underperceived, underdiagnosed and undertreated; a community survey. , 1998, Respiratory medicine.

[106]  P. Sly,et al.  TH2‐polarized immunological memory to inhalant allergens in atopies is established during infaney and early childhood , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[107]  P. Nicholson,et al.  Enzyme exposure, smoking and lung function in employees in the detergent industry over 20 years. Medical Subcommittee of the UK Soap and Detergent Industry Association. , 1997, Occupational medicine.

[108]  G. O'Connor,et al.  Sensitization to cat allergen is associated with asthma in older men and predicts new-onset airway hyperresponsiveness. The Normative Aging Study. , 1997, American journal of respiratory and critical care medicine.

[109]  P. Sly,et al.  Effects of maternal smoking during pregnancy and a family history of asthma on respiratory function in newborn infants , 1996, The Lancet.

[110]  W. Morgan,et al.  Asthma and wheezing in the first six years of life. The Group Health Medical Associates. , 1995, The New England journal of medicine.

[111]  Ayne,et al.  ASTHMA AND WHEEZING IN THE FIRST SIX YEARS OF LIFE , 1995 .

[112]  R. Kronmal,et al.  Prevalence and Correlates of Respiratory Symptoms and Disease in the Elderly , 1994 .

[113]  I. Pavord,et al.  Factors influencing the occurrence of airway hyperreactivity in the general population: the importance of atopy and airway calibre. , 1994, The European respiratory journal.

[114]  T. Nicolai,et al.  Prevalence of asthma and atopy in two areas of West and East Germany. , 1994, American journal of respiratory and critical care medicine.

[115]  C E Reed,et al.  A community-based study of the epidemiology of asthma. Incidence rates, 1964-1983. , 1992, The American review of respiratory disease.

[116]  G. Viegi,et al.  Bronchial hyperresponsiveness, genetic predisposition and environmental factors: the importance of epidemiological research. , 1992, The European respiratory journal.

[117]  C. Salome,et al.  Factors associated with bronchial hyperresponsiveness in Australian adults and children. , 1992, The European respiratory journal.

[118]  M. Hibbert,et al.  Tracking of lung function in healthy children and adolescents , 1990, Pediatric pulmonology.

[119]  D. P. Strachan,et al.  Hay fever, hygiene, and household size. , 1989, BMJ.

[120]  B. Sibbald,et al.  Genetic factors in childhood asthma. , 1980, Thorax.

[121]  L. Longo.  The biological effects of carbon monoxide on the pregnant woman, fetus, and newborn infant. , 1977, American journal of obstetrics and gynecology.

[122]  Lorian,et al.  ENVIRONMENTAL EXPOSURE TO ENDOTOXIN AND ITS RELATION TO ASTHMA IN SCHOOL-AGE CHILDREN , 2022 .