Early and Late Intracortical Inhibition in Juvenile Myoclonic Epilepsy

Summary: Purpose: We investigated 15 patients with juvenile myoclonic epilepsy (JME) by subjecting them to single and paired transcranial magnetic stimulation to test the hypothesis that motor cortical inhibition may be abnormal in this form of benign epilepsy.

[1]  R. Mutani,et al.  Focal subcortical reflex myoclonus. A clinical and neurophysiological study. , 1997, Archives of neurology.

[2]  S. Mastana,et al.  Haptoglobin subtypes among four different populations. , 1994, Human heredity.

[3]  M. Gutnick,et al.  Paired-pulse facilitation of IPSCs in slices of immature and mature mouse somatosensory neocortex. , 1995, Journal of neurophysiology.

[4]  R. J. Lockwood,et al.  The muscle silent period following transcranial magnetic cortical stimulation , 1993, Journal of the Neurological Sciences.

[5]  P. Rossini,et al.  Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. , 1994, Electroencephalography and clinical neurophysiology.

[6]  G Zaccara,et al.  Interictal inhibitory mechanisms in patients with cryptogenic motor cortex epilepsy: a study of the silent period following transcranial magnetic stimulation. , 1998, Electroencephalography and clinical neurophysiology.

[7]  C. Taylor,et al.  Emerging perspectives on the mechanism of action of gabapentin , 1994, Neurology.

[8]  J. Lambert,et al.  Depression of the fast IPSP underlies paired-pulse facilitation in area CA1 of the rat hippocampus. , 1991, Journal of neurophysiology.

[9]  A Berardelli,et al.  Silent period evoked by transcranial stimulation of the human cortex and cervicomedullary junction. , 1993, The Journal of physiology.

[10]  R. Mutani,et al.  Magnetic brain stimulation: the silent period after the motor evoked potential. , 1992, Neurology.

[11]  R. Inzelberg,et al.  Changes in excitability of motor cortical circuitry in patients with parkinson's disease , 1995, Annals of neurology.

[12]  G. Thickbroom,et al.  The muscle silent period following transcranial magnetic stimulation , 1992 .

[13]  M Hallett,et al.  Transcranial magnetic stimulation. Negative effects. , 1995, Advances in neurology.

[14]  T. Sander,et al.  Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients , 1991, Neurology.

[15]  C. Marsden,et al.  Corticocortical inhibition in human motor cortex. , 1993, The Journal of physiology.

[16]  Massimo Avoli,et al.  GABA and Epileptogenesis , 1997, Epilepsia.

[17]  W. Paulus,et al.  Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis , 1997, Neurology.

[18]  D. Janz,et al.  The Idiopathic Generalized Epilepsies of Adolescence with Childhood and Juvenile Age of Onset , 1997, Epilepsia.

[19]  C E Elger,et al.  Magnetic motor‐evoked potentials in epilepsy: Effects of the disease and of anticonvulsant medication , 1990, Annals of neurology.

[20]  B. Steinhoff,et al.  Effects of antiepileptic drugs on motor cortex excitability in humans: A transcranial magnetic stimulation study , 1996, Annals of neurology.

[21]  J C Rothwell,et al.  Abnormalities of the balance between inhibition and excitation in the motor cortex of patients with cortical myoclonus. , 1996, Brain : a journal of neurology.

[22]  Y. Kang,et al.  Spatiotemporally differential inhibition of pyramidal cells in the cat motor cortex. , 1994, Journal of neurophysiology.

[23]  M. Hallett,et al.  Spinal motor neuron excitability during the silent period after cortical stimulation. , 1991, Electroencephalography and clinical neurophysiology.

[24]  B Conrad,et al.  Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia , 1998, Muscle & nerve.

[25]  D C Reutens,et al.  Magnetic stimulation of the brain in generalized epilepsy: Reversal of cortical hyperexcitability by anticonvulsants , 1993, Annals of neurology.

[26]  A. Strafella,et al.  Facilitation of rhythmic events in progressive myoclonus epilepsy: a transcranial magnetic stimulation study , 1999, Clinical Neurophysiology.

[27]  H. Tsuji,et al.  Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans. , 1997, The Journal of physiology.

[28]  W Paulus,et al.  Inhibition of human motor cortex by ethanol. A transcranial magnetic stimulation study. , 1995, Brain : a journal of neurology.

[29]  M. Dichter,et al.  Cellular mechanisms of epilepsy: a status report. , 1987, Science.

[30]  P. Rossini,et al.  'Excitability changes of muscular responses to magnetic brain stimulation in patients with central motor disorders. , 1991, Electroencephalography and clinical neurophysiology.

[31]  L. Benardo,et al.  Recruitment of GABAergic inhibition and synchronization of inhibitory interneurons in rat neocortex. , 1997, Journal of neurophysiology.

[32]  A. Berardelli,et al.  Cortical inhibition in Parkinson's disease. A study with paired magnetic stimulation. , 1996, Brain : a journal of neurology.

[33]  D. McCormick,et al.  GABA as an inhibitory neurotransmitter in human cerebral cortex. , 1989, Journal of neurophysiology.

[34]  F. Sartucci,et al.  Cortical reflex myoclonus in rett syndrome , 1998, Annals of neurology.

[35]  B. Shahani,et al.  Motor inhibition and excitation are independent effects of magnetic cortical stimulation , 1992, Annals of neurology.

[36]  Ichiro Kanazawa,et al.  Ipsilateral cortico-cortical inhibition of the motor cortex in various neurological disorders , 1996, Journal of the Neurological Sciences.

[37]  M. Hallett,et al.  Optimal Focal Transcranial Magnetic Activation of the Human Motor Cortex: Effects of Coil Orientation, Shape of the Induced Current Pulse, and Stimulus Intensity , 1992, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[38]  B. Day,et al.  MOTOR CORTEX EXCITABILITY IN FOCAL AND GENERALIZED EPILEPSY , 1993 .

[39]  L. Benardo,et al.  Separate activation of fast and slow inhibitory postsynaptic potentials in rat neocortex in vitro. , 1994, The Journal of physiology.

[40]  M Hallett,et al.  Cortical modulation of spinal excitability: an F-wave study. , 1996, Electroencephalography and clinical neurophysiology.

[41]  D. Prince,et al.  Frequency‐dependent depression of inhibition in guinea‐pig neocortex in vitro by GABAB receptor feed‐back on GABA release. , 1989, The Journal of physiology.

[42]  A Berardelli,et al.  Alterations of motor cortical inhibition in patients with dystonia , 1998, Movement disorders : official journal of the Movement Disorder Society.