New implementation of Elliptic Systems Method for time dependent diffusion tomography with back reflected and transmitted boundary data

Abstract A problem of coefficient recovery from incomplete boundary data in inverse problems is considered. It uses a new implementation of the Elliptic Systems Method (ESM) in time dependent diffusion tomography. The basic formulation of the ESM involves solving a system of coupled fourth-order partial differential equations, with the time variable integrated out using Legendre polynomials. Here, we use C 1 Bogner–Fox–Schmit bi-cubic elements over rectangles, with a new treatment of boundary conditions in the common case of incomplete boundary data. This new method is fourth-order accurate for sufficiently smooth functions. The new boundary condition approach allows the use of homogeneous natural boundary conditions on parts of the boundary where no measured data is available. We will focus on a comparison with three previously published examples using back reflected or transmitted data with one or two inclusions. The new implementation gives markedly improved results for inclusion recovery, all of which are achieved without use of additional aids such as weight functions which previously have been thought to be essential, and is shown to be surprisingly robust with respect to noise. We conclude with two examples illustrating the effect of increasing levels of noise.

[1]  Robert R. Alfano,et al.  Time-resolved fluorescence and photon migration studies in biomedical and model random media , 1997 .

[2]  T. R. Lucas,et al.  A fast and accurate imaging algorithm in optical/diffusion tomography , 1997 .

[3]  James H. Bramble,et al.  Multigrid methods for the biharmonic problem discretized by conforming C 1 finite elements on nonnested meshes , 1995 .

[4]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[5]  MICHAEL V. KLIBANOV,et al.  Numerical Solution of a Parabolic Inverse Problem in Optical Tomography Using Experimental Data , 1999, SIAM J. Appl. Math..

[6]  S R Arridge,et al.  Recent advances in diffuse optical imaging , 2005, Physics in medicine and biology.

[7]  Andreas H Hielscher,et al.  Optical tomographic imaging of small animals. , 2005, Current opinion in biotechnology.

[8]  Carl de Boor,et al.  A Practical Guide to Splines , 1978, Applied Mathematical Sciences.

[9]  M. C. Jones,et al.  Spline Smoothing and Nonparametric Regression. , 1989 .

[10]  Irfan Altas,et al.  Multigrid Solution of Automatically Generated High-Order Discretizations for the Biharmonic Equation , 1998, SIAM J. Sci. Comput..

[11]  Guillaume Bal,et al.  Optical tomography for small volume absorbing inclusions , 2003 .

[12]  J. Júdice,et al.  On the solution of a finite element approximation of a linear obstacle plate problem , 2002 .

[13]  S. Arridge Optical tomography in medical imaging , 1999 .

[14]  Achi Brandt,et al.  Effective Boundary Treatment for the Biharmonic Dirichlet Problem , 1996 .

[15]  T. R. Lucas,et al.  Elliptic systems method in diffusion tomography using back-reflected data , 2000 .