Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis.
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L. Zardi | D. Neri | F. Viti | L. Giovannoni | L. Tarli | Luciano Zardi | Dario Neri
[1] A. Pini,et al. Design and Use of a Phage Display Library , 1998, The Journal of Biological Chemistry.
[2] R. Brekken,et al. Vascular endothelial growth factor as a marker of tumor endothelium. , 1998, Cancer research.
[3] Neri,et al. Affinity reagents against tumour-associated extracellular molecules and newforming vessels. , 1998, Advanced drug delivery reviews.
[4] G. Adams,et al. Increased affinity leads to improved selective tumor delivery of single-chain Fv antibodies. , 1998, Cancer research.
[5] Dario Neri,et al. Targeting by affinity–matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform , 1997, Nature Biotechnology.
[6] Erkki Ruoslahti,et al. αv Integrins as receptors for tumor targeting by circulating ligands , 1997, Nature Biotechnology.
[7] Grietje Molema,et al. Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature , 1997, Science.
[8] William Arbuthnot Sir Lane,et al. Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth , 1997, Cell.
[9] U. Schmidt-Erfurth,et al. Photodynamic targeting of human retinoblastoma cells using covalent low-density lipoprotein conjugates. , 1997, British Journal of Cancer.
[10] D. Neri,et al. Biophysical methods for the determination of antibody-antigen affinities. , 1996, Trends in biotechnology.
[11] A. Pini,et al. Phage antibodies with pan‐species recognition of the oncofoetal angiogenesis marker fibronectin ED‐B domain , 1996, International journal of cancer.
[12] R. Hawkins,et al. Clinical evidence of efficient tumor targetting based on single–chain Fv antibody selected from a combinatorial library , 1996, Nature Medicine.
[13] G. Winter,et al. Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain. , 1996, Journal of molecular biology.
[14] J. Folkman,et al. Angiostatin induces and sustains dormancy of human primary tumors in mice , 1996, Nature Medicine.
[15] G. Winter,et al. Radioactive labeling of recombinant antibody fragments by phosphorylation using human casein kinase II and [γ-32P]-ATP , 1996, Nature Biotechnology.
[16] L E Williams,et al. Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers. , 1996, Immunotechnology : an international journal of immunological engineering.
[17] J. Larrick,et al. Identification of functional and structural amino-acid residues by parsimonious mutagenesis. , 1996, Gene.
[18] David A. Cheresh,et al. Definition of Two Angiogenic Pathways by Distinct αv Integrins , 1995, Science.
[19] D R Burton,et al. CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range. , 1995, Journal of molecular biology.
[20] R. Schmitz,et al. Generation of Rabbit Monoclonal Antibody Fragments from a Combinatorial Phage Display Library and Their Production in the Yeast Pichia pastoris , 1995, Bio/Technology.
[21] R. Begent,et al. Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography. , 1995, Journal of immunological methods.
[22] J. Folkman. Angiogenesis in cancer, vascular, rheumatoid and other disease , 1995, Nature Medicine.
[23] L. Zardi,et al. The fibronectin isoform containing the ed‐b oncofetal domain: A marker of angiogenesis , 1994, International journal of cancer.
[24] R. Owens,et al. Improved tumor targeting with chemically cross-linked recombinant antibody fragments. , 1994, Cancer research.
[25] L. Zardi,et al. Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues , 1994, International journal of cancer.
[26] Hennie R. Hoogenboom,et al. Guiding the Selection of Human Antibodies from Phage Display Repertoires to a Single Epitope of an Antigen , 1994, Bio/Technology.
[27] G. Winter,et al. In vitro assembly of repertoires of antibody chains on the surface of phage by renaturation. , 1994, Journal of molecular biology.
[28] H. Bergh,et al. Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice. , 1994, Cancer research.
[29] G. Winter,et al. Making antibodies by phage display technology. , 1994, Annual review of immunology.
[30] A. Plückthun,et al. Improved Bivalent Miniantibodies, with Identical Avidity as Whole Antibodies, Produced by High Cell Density Fermentation of Escherichia coli , 1993, Nature Biotechnology.
[31] L L Houston,et al. Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv. , 1993, Cancer research.
[32] T Prospero,et al. "Diabodies": small bivalent and bispecific antibody fragments. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[33] Bing Li,et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo , 1993, Nature.
[34] H. Linardou,et al. Review: advances in monoclonal antibody tumour targeting. , 1993, Journal of drug targeting.
[35] Brad Snedecor,et al. High Level Escherichia coli Expression and Production of a Bivalent Humanized Antibody Fragment , 1992, Bio/Technology.
[36] R. Karlsson,et al. Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology. , 1991, BioTechniques.
[37] R. Jain,et al. Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues. , 1990, Cancer research.
[38] L. Zardi,et al. A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors , 1989, The Journal of cell biology.
[39] K. D. Hardman,et al. Single-chain antigen-binding proteins. , 1988, Science.
[40] J. Schlom,et al. Radioimmunolocalization of human carcinoma xenografts with B72.3 second generation monoclonal antibodies. , 1988, Cancer research.
[41] R. Bruccoleri,et al. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[42] F. Baralle,et al. Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon. , 1987, The EMBO journal.
[43] S. Munro,et al. An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein , 1986, Cell.
[44] J. Sambrook,et al. Molecular Cloning: A Laboratory Manual , 2001 .
[45] J. Sykes,et al. Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenyl glycoluril (Iodogen). , 1981, Analytical biochemistry.
[46] D M Crothers,et al. The influence of polyvalency on the binding properties of antibodies. , 1972, Immunochemistry.