Effect of progesterone on colonic motility and fecal output in mice with diarrhea

Background  Patients with diarrhea and slow transit constipation (STC) have high 5‐HT levels. In STC, the high 5‐HT levels have been difficult to explain, as 5‐HT stimulates peristalsis. Over expression of progesterone (P4) receptors in epithelial and muscle cells of the colon may reconcile this contradiction because P4 decreases SERT and increases 5‐HT levels, but their effects are rendered ineffective because of the impaired muscle contraction.

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