Uraemic toxin reduction: A newly found effect of hydrolysable‐type tannin‐containing crude drug and gallotannin

The levels of urea nitrogen, creatinine, methylguanidine and guanidinosuccinic acid, which accumulate in blood in parallel with the progress of renal failure after adenine administration, were decreased significantly in rats given Galla Rhois, Moutan Cortex or Paeoniae Radix extract. Administration of Galla Rhois extract was found to be more effective than the other two crude drugs in decreasing the uraemic toxin parameters. A uraemic toxin‐decreasing effect similar to that of crude drug was also obtained using 1,3,6‐tri‐O‐galloyl‐β‐D‐glucopyranose and 1,2,3,4,6‐penta‐O‐galloyl‐β‐D‐glucopyranose.

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