Juvenile Polyposis Syndrome -Two Case Reports Abstract: Juvenile polyposis syndrome is a rare condition characterized by the presence of numerous harmatomatous polyps in the gastrointestinal tract and associated with a risk for colorectal cancer. Juvenile polyposis

Juvenile polyposis syndrome is a rare condition characterized by the presence of numerous harmatomatous polyps in the gastrointestinal tract and associated with a risk for colorectal cancer. Juvenile polyposis syndrome has been scarcely reported in Africa and this will be the index cases reported in Ghana. We report two cases of juvenile polyposis syndrome diagnosed and managed in our facility. They both presented with gastrointestinal bleeding and the polyps were identified at endoscopy. Histopathological confirmation of the diagnosis in the first case was delayed leading to death of patient from severe anaemia but the second case underwent a pan-colectomy. The report highlights the occurrence of this precancerous condition, the variety in anatomic presentation of the disease, the diagnostic difficulties and the management challenges.

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