Oscillometric Blood Pressure Estimation Based on Deep Learning

Oscillometric measurement is widely used to estimate systolic blood pressure (SBP) and diastolic blood pressure (DBP). In this paper, we propose a deep belief network (DBN)-deep neural network (DNN) to learn about the complex nonlinear relationship between the artificial feature vectors obtained from the oscillometric wave and the reference nurse blood pressures using the DBN-DNN-based-regression model. Our DBN-DNN is a powerful generative network for feature extraction and can address to stick in local minima through a special pretraining phase. Therefore, this model provides an alternative way for replacing a popular shallow model. Based on this, we apply the DBN-DNN-based regression model to estimate the SBP and DBP. However, there are a small amount of data samples, which is not enough to train the DBN-DNN without the overfitting problem. For this reason, we use the parametric bootstrap-based artificial features, which are used as training samples to efficiently learn the complex nonlinear functions between the feature vectors obtained and the reference nurse blood pressures. As far as we know, this is one of the first studies using the DBN-DNN-based regression model for BP estimation when a small training sample is available. Our DBN-DNN-based regression model provides a lower standard deviation of error, mean error, and mean absolute error for the SBP and DBP as compared with the conventional methods.

[1]  Xiao-Lei Zhang,et al.  Deep Belief Networks Based Voice Activity Detection , 2013, IEEE Transactions on Audio, Speech, and Language Processing.

[2]  Joon-Hyuk Chang,et al.  Oscillometric Blood Pressure Estimation Based on Maximum Amplitude Algorithm Employing Gaussian Mixture Regression , 2013, IEEE Transactions on Instrumentation and Measurement.

[3]  S. T. Buckland,et al.  An Introduction to the Bootstrap. , 1994 .

[4]  Yoshua. Bengio,et al.  Learning Deep Architectures for AI , 2007, Found. Trends Mach. Learn..

[5]  K. Singh,et al.  On the Asymptotic Accuracy of Efron's Bootstrap , 1981 .

[6]  Voicu Groza,et al.  Feature-Based Neural Network Approach for Oscillometric Blood Pressure Estimation , 2011, IEEE Transactions on Instrumentation and Measurement.

[7]  Radford M. Neal Pattern Recognition and Machine Learning , 2007, Technometrics.

[8]  F. Massey The Kolmogorov-Smirnov Test for Goodness of Fit , 1951 .

[9]  Wilbert S. Aronow,et al.  Measurement of Blood Pressure. , 1965, Canadian Medical Association journal.

[10]  Guigang Zhang,et al.  Deep Learning , 2016, Int. J. Semantic Comput..

[11]  M. Kenward,et al.  An Introduction to the Bootstrap , 2007 .

[12]  Yoshua Bengio,et al.  Why Does Unsupervised Pre-training Help Deep Learning? , 2010, AISTATS.

[13]  Michael R Neuman,et al.  Measurement of Blood Pressure [Tutorial] , 2011, IEEE Pulse.

[14]  Arata Suzuki,et al.  Feature Selection Method for Estimating Systolic Blood Pressure Using the Taguchi Method , 2014, IEEE Transactions on Industrial Informatics.

[15]  Martin Fodslette Møller,et al.  A scaled conjugate gradient algorithm for fast supervised learning , 1993, Neural Networks.

[16]  Li-Rong Dai,et al.  A Regression Approach to Speech Enhancement Based on Deep Neural Networks , 2015, IEEE/ACM Transactions on Audio, Speech, and Language Processing.

[17]  Voicu Groza,et al.  Measurement of Heart Rate Variability Using an Oscillometric Blood Pressure Monitor , 2010, IEEE Transactions on Instrumentation and Measurement.

[18]  Voicu Groza,et al.  Confidence Interval Estimation for Oscillometric Blood Pressure Measurements Using Bootstrap Approaches , 2011, IEEE Transactions on Instrumentation and Measurement.

[19]  F. Mee,et al.  Evaluation of blood pressure measuring devices. , 1993, Clinical and experimental hypertension.

[20]  Joon-Hyuk Chang,et al.  A new a priori SNR estimator based on multiple linear regression technique for speech enhancement , 2014, Digit. Signal Process..

[21]  B. Ripley,et al.  Pattern Recognition , 1968, Nature.

[22]  Bernd Saugel,et al.  Measurement of blood pressure. , 2014, Best practice & research. Clinical anaesthesiology.

[23]  Geoffrey E. Hinton,et al.  Deep Learning , 2015, Nature.

[24]  Yee Whye Teh,et al.  A Fast Learning Algorithm for Deep Belief Nets , 2006, Neural Computation.

[25]  R. Tibshirani Regression Shrinkage and Selection via the Lasso , 1996 .

[26]  Voicu Groza,et al.  Coefficient-Free Blood Pressure Estimation Based on Pulse Transit Time–Cuff Pressure Dependence , 2013, IEEE Transactions on Biomedical Engineering.

[27]  Ramakrishna Mukkamala,et al.  Error Mechanisms of the Oscillometric Fixed-Ratio Blood Pressure Measurement Method , 2012, Annals of Biomedical Engineering.

[28]  Voicu Groza,et al.  Estimated confidence interval from single blood pressure measurement based on algorithmic fusion , 2015, Comput. Biol. Medicine.

[29]  Joon-Hyuk Chang,et al.  Improved Gaussian Mixture Regression Based on Pseudo Feature Generation Using Bootstrap in Blood Pressure Estimation , 2016, IEEE Transactions on Industrial Informatics.

[30]  Voicu Groza,et al.  Augmented blood pressure measurement through the noninvasive estimation of physiological arterial pressure variability , 2012, Physiological measurement.

[31]  Alain Rakotomamonjy,et al.  Analysis of SVM regression bounds for variable ranking , 2007, Neurocomputing.

[32]  Jana Kivastik,et al.  Errors of oscillometric blood pressure measurement as predicted by simulation , 2011, Blood pressure monitoring.

[33]  Dwayne Westenskow,et al.  Noninvasive blood pressure monitoring from the supraorbital artery using an artificial neural network oscillometric algorithm , 1995, Journal of Clinical Monitoring.

[34]  Surya Ganguli,et al.  Identifying and attacking the saddle point problem in high-dimensional non-convex optimization , 2014, NIPS.

[35]  Voicu Groza,et al.  Electrocardiogram-Assisted Blood Pressure Estimation , 2012, IEEE Transactions on Biomedical Engineering.