Semliki Forest virus infection is enhanced in Th1-prone SJL mice but not in Th2-prone BALB/c mice during Linomide-induced immunomodulation

[1]  J. Holmgren,et al.  Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection in Mice but Are Not Required for the Development of Acquired Gamma Interferon-Mediated Protective Immunity , 2001, Journal of Virology.

[2]  G. Hedlund,et al.  Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system. , 2001, International immunopharmacology.

[3]  G. Hedlund,et al.  The immunomodulator Linomide: role in treatment and prevention of autoimmune diabetes mellitus. , 2001, International immunopharmacology.

[4]  R. Martin,et al.  Mechanisms of immunomodulation by glatiramer acetate , 2000, Neurology.

[5]  F. Lublin,et al.  Linomide in relapsing and secondary progressive MS , 2000, Neurology.

[6]  F. Barkhof,et al.  Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trials , 2000, Multiple sclerosis.

[7]  Z. Xing,et al.  IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-γ Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes1 , 2000, The Journal of Immunology.

[8]  G. Hedlund,et al.  Inhibition of Autoimmune Disease by the Immunomodulator Linomide Correlates with the Ability to Activate Macrophages , 2000, Autoimmunity.

[9]  C. Brosnan,et al.  Cytokine, chemokine and chemokine receptor mRNA expression in different strains of normal mice: implications for establishment of a Th1/Th2 bias , 1999, Journal of Neuroimmunology.

[10]  D. Karussis,et al.  Linomide downregulates autoimmunity through induction of TH2 cytokine production by lymphocytes. , 1999, Immunology letters.

[11]  A. al‐Sabbagh,et al.  Interferon beta modulates experimental autoimmune encephalomyelitis by altering the pattern of cytokine secretion. , 1999, Immunological investigations.

[12]  R. Zinkernagel,et al.  IL-12 is not required for induction of type 1 cytokine responses in viral infections. , 1999, Journal of immunology.

[13]  R. Salonen,et al.  Selective downregulation of Th1 response by Linomide reduces autoimmunity but increases susceptibility to viral infection in BALB/c and SJL mice , 1998, Journal of Neuroimmunology.

[14]  C. Lucchinetti,et al.  Failure of treatment with Linomide or oral myelin tolerization to ameliorate demyelination in a viral model of multiple sclerosis , 1998, Journal of Neuroimmunology.

[15]  B. Haagmans,et al.  Mice lacking IL-12 develop polarized Th1 cells during viral infection. , 1998, Journal of immunology.

[16]  D. Klatzmann,et al.  Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover. , 1998, Journal of immunology.

[17]  F. Shi,et al.  Linomide-induced suppression of experimental autoimmune neuritis is associated with down-regulated macrophage functions , 1997, Journal of Neuroimmunology.

[18]  L. Harbige,et al.  Characterization of the cellular and cytokine response in the central nervous system following Semliki Forest virus infection , 1997, Journal of Neuroimmunology.

[19]  E. Shezen,et al.  Immunomodulation of autoimmunity by linomide: inhibition of antigen presentation through down regulation of macrophage activity in the model of experimental autoimmune encephalomyelitis , 1997, Journal of Neuroimmunology.

[20]  S. Ekholm,et al.  Linomide reduces the rate of active lesions in relapsing-remitting multiple sclerosis. , 1996, Multiple sclerosis.

[21]  R. Kaempfer,et al.  Linomide, an immunomodulator that inhibits Th1 cytokine gene expression. , 1996, International immunology.

[22]  Z. Meiner,et al.  Treatment of secondary progressive multiple sclerosis with the immunomodulator linomide , 1996, Neurology.

[23]  R. Sobel,et al.  Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis , 1996, Journal of Neuroimmunology.

[24]  R. Salonen,et al.  Blood-brain barrier breakdown and increased intercellular adhesion molecule (ICAM-1/CD54) expression after Semliki Forest ( A7) virus infection facilitates the development of experimental allergic encephalomyelitis , 1996, Journal of Neuroimmunology.

[25]  W. Dietrich,et al.  Genetic Susceptibility to Leishmania: IL-12 Responsiveness in TH1 Cell Development , 1996, Science.

[26]  J. Fazakerley,et al.  Role of immune responses in protection and pathogenesis during Semliki Forest virus encephalitis. , 1996, The Journal of general virology.

[27]  M. D. de Bruijn,et al.  Markers of mouse macrophage development detected by monoclonal antibodies. , 1994, Journal of immunological methods.

[28]  F. Mokhtarian,et al.  Immune responses, and autoimmune outcome, during virus infection of the central nervous system. , 1994, Cellular immunology.

[29]  G. Kroemer,et al.  Linomide inhibits programmed cell death of peripheral T cells in vivo , 1994, European journal of immunology.

[30]  A. Ben-nun,et al.  Inhibition of acute, experimental autoimmune encephalomyelitis by the synthetic immunomodulator linomide , 1993, Annals of neurology.

[31]  D. Karussis,et al.  Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide). , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[32]  T. Kalland Regulation of natural killer progenitors. Studies with a novel immunomodulator with distinct effects at the precursor level. , 1990, Journal of immunology.

[33]  R. Steinman,et al.  The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies , 1990, The Journal of experimental medicine.

[34]  M. Mäkelä,et al.  Effect of viral infection on experimental allergic encephalomyelitis in mice , 1988, Journal of Neuroimmunology.

[35]  J. Fazakerley,et al.  Cyclosporine enhances virally induced T-cell-mediated demyelination The effect of cyclosporine on a demyelinating virus infection , 1987, Journal of the Neurological Sciences.

[36]  J A Maples,et al.  A method for the covalent attachment of cells to glass slides for use in immunohistochemical assays. , 1985, American journal of clinical pathology.

[37]  J. Fazakerley,et al.  Aurothiolates enhance the replication of Semliki Forest virus in the CNS and the exocrine pancreas. , 1999, Journal of neurovirology.