Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples.

Fifty-seven pooled archived human serum samples were analyzed to assess the time trends as well as influence of age and gender on selected perfluorinated compounds (PFCs) in Norwegian residents. The study comprised determinations of 19 PFCs in serum samples pooled according to year of collection from 28 years in the period 1976 to 2007. A 9-fold increase in the serum concentrations of perfluorooctyl sulfonate, perfluorooctanoic acid, and perfluoroheptyl sulfonate was measured for men (40-50 years) from 1977 to the mid 1990s where the concentrations reached a plateau before starting to decrease around year 2000. A similar trend was also seen for perfluorohexyl sulfonate, perfluorononanoic acid, perfluorodecanoic acid, and perfluoroundecanoic acid, but no clear decline was observed for these PFCs in the recent years. No statistically significant difference was observed between the PFC levels in the male and female serum pools, though the statistical power is low due to few data points. For most PFCs, the concentrations in the human serum samples were found to increase with age in the pools from 2007, while the results for 1976, 1987, and 1998 were more varying. Several PFCs were significantly intercorrelated.

[1]  Wenyue Hu,et al.  Binding of perfluorinated fatty acids to serum proteins , 2003, Environmental toxicology and chemistry.

[2]  F. Benoit,et al.  A pilot study on the determination of perfluorooctanesulfonate and other perfluorinated compounds in blood of Canadians. , 2004, Journal of environmental monitoring : JEM.

[3]  Martin Scheringer,et al.  Estimating the contribution of precursor compounds in consumer exposure to PFOS and PFOA. , 2008, Chemosphere.

[4]  A. Calafat,et al.  Perfluorinated chemicals in selected residents of the American continent. , 2006, Chemosphere.

[5]  Marie Aune,et al.  Exposure of Perfluorinated Chemicals through Lactation: Levels of Matched Human Milk and Serum and a Temporal Trend, 1996–2004, in Sweden , 2006, Environmental health perspectives.

[6]  P. Dumas,et al.  Plasma Concentrations of Selected Organobromine Compounds and Polychlorinated Biphenyls in Postmenopausal Women of Québec, Canada , 2007, Environmental health perspectives.

[7]  John W. Froehlich,et al.  Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers , 2007, Environmental health perspectives.

[8]  Derek C G Muir,et al.  Biological monitoring of polyfluoroalkyl substances: A review. , 2006, Environmental science & technology.

[9]  Bert van Bavel,et al.  Identification and pattern of perfluorooctane sulfonate (PFOS) isomers in human serum and plasma. , 2007, Environment international.

[10]  Jeffrey H Mandel,et al.  Serum concentrations of perfluorooctanesulfonate and other fluorochemicals in an elderly population from Seattle, Washington. , 2004, Chemosphere.

[11]  Geary W Olsen,et al.  Preliminary evidence of a decline in perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations in American Red Cross blood donors. , 2007, Chemosphere.

[12]  Paul D. Jones,et al.  Accumulation of perfluorooctane sulfonate in marine mammals. , 2001, Environmental science & technology.

[13]  L. S. Haug,et al.  A sensitive method for determination of a broad range of perfluorinated compounds in serum suitable for large-scale human biomonitoring. , 2009, Journal of chromatography. A.

[14]  Kouji Harada,et al.  The Influence of Time, Sex and Geographic Factors on Levels of Perfluorooctane Sulfonate and Perfluorooctanoate in Human Serum over the Last 25 years , 2004, Journal of occupational health.

[15]  Fiona Harden,et al.  Levels of 12 perfluorinated chemicals in pooled australian serum, collected 2002-2003, in relation to age, gender, and region. , 2006, Environmental science & technology.

[16]  Konrad Hungerbühler,et al.  Estimating Consumer Exposure to PFOS and PFOA , 2008, Risk analysis : an official publication of the Society for Risk Analysis.

[17]  Timothy R Church,et al.  Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006. , 2008, Environmental science & technology.

[18]  C. Thomsen,et al.  Automated solid-phase extraction for the determination of polybrominated diphenyl ethers and polychlorinated biphenyls in serum--application on archived Norwegian samples from 1977 to 2003. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[19]  A. Koizumi,et al.  Historical trends in human serum levels of perfluorooctanoate and perfluorooctane sulfonate in Shenyang, China. , 2007, The Tohoku journal of experimental medicine.

[20]  Jeffrey H Mandel,et al.  Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors. , 2003, Environmental health perspectives.

[21]  S. Tittlemier,et al.  Dietary exposure of Canadians to perfluorinated carboxylates and perfluorooctane sulfonate via consumption of meat, fish, fast foods, and food items prepared in their packaging. , 2007, Journal of agricultural and food chemistry.

[22]  Bert van Bavel,et al.  Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: a pilot study. , 2007, Environment international.

[23]  H Fromme,et al.  Occurrence of perfluorinated substances in an adult German population in southern Bavaria , 2007, International archives of occupational and environmental health.

[24]  C. Lau,et al.  Perfluoroalkyl acids: a review of monitoring and toxicological findings. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[25]  A. Calafat,et al.  Perfluorochemicals in pooled serum samples from United States residents in 2001 and 2002. , 2006, Environmental science & technology.

[26]  Andreas Gies,et al.  The Environmental Specimen Bank for Human Tissues as part of the German Environmental Specimen Bank. , 2007, International journal of hygiene and environmental health.

[27]  A. Calafat,et al.  Serum concentrations of 11 polyfluoroalkyl compounds in the u.s. population: data from the national health and nutrition examination survey (NHANES). , 2007, Environmental science & technology.

[28]  S. Tittlemier,et al.  Concentrations of perfluorooctanesulfonamides in Canadian total diet study composite food samples collected between 1992 and 2004. , 2006, Journal of agricultural and food chemistry.

[29]  Paul D. Jones,et al.  Perfluorooctane sulfonate in fish-eating water birds including bald eagles and albatrosses. , 2001, Environmental science & technology.

[30]  K. Helzlsouer,et al.  Historical Comparison of Perfluorooctanesulfonate, Perfluorooctanoate, and Other Fluorochemicals in Human Blood , 2005, Environmental health perspectives.

[31]  M. A. Mohd,et al.  Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries. , 2004, Environmental science & technology.

[32]  Hermann Fromme,et al.  Perfluorinated compounds--exposure assessment for the general population in Western countries. , 2009, International journal of hygiene and environmental health.

[33]  Andrea Pfahles-Hutchens,et al.  The Applicability of Biomonitoring Data for Perfluorooctanesulfonate to the Environmental Public Health Continuum , 2006, Environmental health perspectives.

[34]  Kouji Harada,et al.  Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan. , 2007, Chemosphere.

[35]  A. Calafat,et al.  Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and Comparisons with NHANES 1999–2000 , 2007, Environmental health perspectives.