Granulocytic Sarcoma (Chloroma) Presenting as Multiple Sites in Oral Cavity: Report of a Case

Granulocytic Sarcoma (GS), an unusual extramedullary tumor, is composed of immature granulocytic precursor cells. The intraoral occurrence of this tumor is extremely rare. Here, we report a case of GS with palatal swelling, gingival lesions in maxilla and mandible and aleukemic presentation in a 45- year- old male.

[1]  Zhe Zhang,et al.  Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF. , 2011, Leukemia research.

[2]  I. Vélez,et al.  A rare case of granulocytic sarcoma in the mandible of a 4-year-old child: a case report and review of the literature. , 2009, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[3]  Zhijian Xie,et al.  Intraoral granulocytic sarcoma presenting as multiple maxillary and mandibular masses: a case report and literature review. , 2007, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[4]  M. Koudstaal,et al.  Granulocytic sarcoma (chloroma) of the oral cavity: Report of a case and literature review , 2006 .

[5]  E. Coskun,et al.  Intracerebellar granulocytic sarcoma complicating acute myelogenous leukemia: a case report and review of the literature , 2004, Journal of Clinical Neuroscience.

[6]  A. Sharma,et al.  Facial palsy as first presentation of acute myeloid leukemia , 2003, American journal of hematology.

[7]  B. Antmen,et al.  Granulocytic sarcoma of gingiva: an unusual case with aleukemic presentation. , 2003, Journal of periodontology.

[8]  K. Yamauchi,et al.  Comparison in treatments of nonleukemic granulocytic sarcoma , 2002, Cancer.

[9]  S. C. Choi,et al.  Granulocytic sarcoma occurring in the maxillary gingiva demonstrated by magnetic resonance imaging. , 2001, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[10]  S. Uğraş,et al.  Head and Neck Granulocytic Sarcoma with Acute Myeloid Leukemia: Three Rare Cases , 2001, Ear, nose, & throat journal.

[11]  B. Wiatrak,et al.  Chloroma of the masseteric muscle. , 2000, International journal of pediatric otorhinolaryngology.

[12]  S. Paydaş,et al.  Granulocytic sarcoma as the cause of giant abdominal mass: diagnosis by fine needle aspiration and review of the literature. , 2000, Leukemia research.

[13]  S Dilly,et al.  Bone marrow pathology , 1949 .

[14]  G. Almadori,et al.  Facial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature. , 1996, International journal of pediatric otorhinolaryngology.

[15]  A. Gratwohl,et al.  Granulocytic sarcoma after allogeneic bone marrow transplantation: a retrospective European multicenter survey. Acute and Chronic Leukemia Working Parties of the European Group for Blood and Marrow Transplantation. , 1996, Bone marrow transplantation.

[16]  D. Selby,et al.  Isolated Chloroma: The Effect of Early Antileukemic Therapy , 1995, Annals of Internal Medicine.

[17]  E. Jaffe,et al.  Extramedullary myeloid cell tumors. An immunohistochemical study of 29 cases using routinely fixed and processed paraffin-embedded tissue sections. , 1995, Archives of pathology & laboratory medicine.

[18]  J. Hamada,et al.  A Possible Role of 92 kDa Type IV Collagenase in the Extramedullary Tumor Formation in Leukemia , 1995, Japanese journal of cancer research : Gann.

[19]  T. Miyazaki,et al.  Establishment of a novel granulocytic sarcoma cell line which can adhere to dermal fibroblasts from a patient with granulocytic sarcoma in dermal tissues and myelofibrosis , 1992, British journal of haematology.

[20]  E. Eisenberg,et al.  Granulocytic sarcoma (chloroma) of the gingiva: report of a case. , 1991, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[21]  C. Koopmann,et al.  Facial nerve paresis as the presenting symptom of leukemia. , 1990, International journal of pediatric otorhinolaryngology.

[22]  J. Quivey,et al.  Granulocytic sarcoma (chloroma) of the oral cavity: a case with aleukemic presentation. , 1987, Oral surgery, oral medicine, and oral pathology.

[23]  P. Reichart,et al.  Mandibular myelosarcoma (chloroma): primary oral manifestation of promyelocytic leukemia. , 1984, Oral surgery, oral medicine, and oral pathology.

[24]  R. Baehner,et al.  Oral manifestations of acute leukemia in children. , 1977, Journal of the American Dental Association.

[25]  G. Dock CHLOROMA AND ITS RELATION TO LEUKÆMIA , 1893 .

[26]  O'Connell Raye,et al.  A Rare Case , 1870, The Indian medical gazette.

[27]  Alexander King Case of Chloroma , 1853, Monthly Journal of Medical Science.

[28]  Observations on the Surgical Anatomy of the Head and Neck , 1816, The Medico-Chirurgical Journal and Review.

[29]  R. Hills,et al.  Independent prognostic variables in acute myeloid leukaemia. , 2011, Blood reviews.

[30]  A. Ciftci,et al.  Granulocytic sarcoma of the scapula: an unusual presentation of acute myeloblastic leukemia. , 1997, Journal of pediatric surgery.

[31]  J. Regezi,et al.  Oral pathology: Clinical-pathologic correlations , 1989 .

[32]  T. Fahmi,et al.  A case of chloroma. , 1951, The Journal of the Egyptian Medical Association.