Occupational allergic rhinoconjunctivitis and asthma due to fennel seed.

BACKGROUND A patient with complaints of rhinitis and asthma occurring at work presented for consultation. OBJECTIVES To evaluate the role of the foods and spices with which he worked, in the causation of his complaints, and to evaluate his immune reactivity to these materials. METHODS Allergy skin testing and in vitro RAST assays were carried out. After demonstrating specific reactivity to fennel, SDS-PAGE electrophoreses was carried out. RESULTS Positive skin tests to grass, ragweed, and freshly prepared fennel seed were found. Serum IgE antibodies to fennel were quite high. Immunoblotting studies showed reactions to two components in fennel extract as well as to components in mugwort, paprika, short ragweed and black pepper. CONCLUSION This case of occupational rhinitis and asthma in an atopic individual involves sensitivity to unique allergens in fennel, with molecular weights of 67 to 75 KD.

[1]  P. Dieges,et al.  Demonstration of spice-specific IgE in patients with suspected food allergies. , 1987, The Journal of allergy and clinical immunology.

[2]  H. Tukiainen,et al.  Three cases of occupational asthma and rhinitis caused by garlic , 1993, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[3]  P. Dieges,et al.  Immunoglobulin E antibodies against coriander and other spices. , 1985, The Journal of allergy and clinical immunology.

[4]  B. Baldo,et al.  Standardization of allergens. Qualitative definition of house dust mite extracts following electroblotting and detection of components with antibody and lectin probes. , 1984, International archives of allergy and applied immunology.

[5]  I. Bernstein,et al.  Occupational asthma induced by inhalation and ingestion of garlic. , 1982, The Journal of allergy and clinical immunology.

[6]  W Q Sturner,et al.  Fatal food-induced anaphylaxis. , 1988, JAMA.

[7]  C. Zeiss,et al.  Occupational asthma secondary to inhalation of garlic dust. , 1981, The Journal of allergy and clinical immunology.

[8]  W Q Sturner,et al.  Laboratory investigation of deaths due to anaphylaxis. , 1991, Journal of forensic sciences.