Development of an Arsenobetaine Standard Solution with Metrological Traceability to the SI by an Arsenic‐specific Mass Balance Method

An arsenobetaine (AsB) standard solution with metrological traceability to the International System of Units was developed as a calibration standard for the quantitative analysis of AsB. An arsenic-specific mass balance method was established for the certification of the AsB standard solution. The accurate mass fraction of total arsenic in the solution was determined by instrumental neutron activation analysis with direct comparator method. Arsenic-containing impurities were evaluated by arsenic speciation analysis using liquid chromatography-inductively coupled plasma mass spectrometry (LC-ICP-MS). Two LC separation methods were adopted for comprehensive coverage of the impurities, which include the reversed-phase LC with ion-pairing and the cation exchange chromatography. The only arsenic-containing impurity observed by LC-ICP-MS was trace level of trimethylarsine oxide. The mass fraction of arsenic in the form of AsB was obtained by subtracting the arsenic mass fractions of the impurities from the total arsenic in the standard solution. The between-bottle inhomogeneity of AsB content in the standard solution was less than 0.7%, which was estimated from the relative standard deviation of the measurement results obtained from 10 representative sample bottles from a batch. The certified value of AsB and its expanded uncertainty as arsenic mass fraction were assigned to be (51.28 ± 1.17) mg/kg (k = 2 approximately at 95% level of confidence).

[1]  Z. Mester,et al.  Report of the CCQM-K97: measurement of arsenobetaine standard solution and arsenobetaine content in fish tissue (tunafish) , 2017 .

[2]  Hyun Seok Lee,et al.  Sulfur-based absolute quantification of proteins using isotope dilution inductively coupled plasma mass spectrometry , 2015 .

[3]  S. Hill,et al.  Coupled techniques for arsenic speciation in food and drinking water: a review , 2015 .

[4]  Michelle M. Nearing,et al.  Complementary arsenic speciation methods: A review , 2014 .

[5]  Mingli Chen,et al.  New procedures for arsenic speciation: a review. , 2014, Talanta.

[6]  D. Yuan,et al.  Speciation and detection of arsenic in aqueous samples: a review of recent progress in non-atomic spectrometric methods. , 2014, Analytica chimica acta.

[7]  Y. Yim,et al.  Accurate measurement of bromine contents in plastic samples by instrumental neutron activation analysis. , 2013, Analytica chimica acta.

[8]  S. H. Kim,et al.  Purity Assessment of Organic Reference Materials with a Mass Balance Method: A Case Study of Endosulfan-II , 2013 .

[9]  Kevin A. Francesconi,et al.  An improved HPLC–ICPMS method for determining inorganic arsenic in food: Application to rice, wheat and tuna fish , 2012 .

[10]  H. M. Anawar,et al.  Arsenic speciation in environmental samples by hydride generation and electrothermal atomic absorption spectrometry. , 2012, Talanta.

[11]  E. A. N. Fernandes,et al.  Neutron activation analysis: A primary method of measurement , 2011 .

[12]  K. Chiba,et al.  Accurate determination of arsenic in arsenobetaine standard solutions of BCR-626 and NMIJ CRM 7901-a by neutron activation analysis coupled with internal standard method. , 2010, Talanta: The International Journal of Pure and Applied Analytical Chemistry.

[13]  K. Francesconi.  Arsenic species in seafood: Origin and human health implications , 2010 .

[14]  Yong-Sam Chung,et al.  CHARACTERISTICS OF A NEW PNEUMATIC TRANSFER SYSTEM FOR A NEUTRON ACTIVATION ANALYSIS AT THE HANARO RESEARCH REACTOR , 2009 .

[15]  S. Fujiwara,et al.  Rapid determination of arsenic species in freshwater organisms from the arsenic-rich Hayakawa River in Japan using HPLC-ICP-MS. , 2009, Chemosphere.

[16]  Byung-Gun Park,et al.  ANALYSIS OF DOPPLER-BROADENED PEAK IN THERMAL NEUTRON INDUCED10B(n,α γ)7Li REACTION USING HYPERGAM , 2009 .

[17]  Lara L. Chappell,et al.  Arsenic in Seafood: Speciation Issues for Human Health Risk Assessment , 2009 .

[18]  A. Hirner,et al.  Determination of arsenic species in human urine using high performance liquid chromatography (HPLC) coupled with inductively coupled plasma mass spectrometry (ICP-MS) , 2008 .

[19]  K. Chiba,et al.  Analytical sensitivity of arsenobetaine on atomic spectrometric analysis and the purity of synthetic arsenobetaine , 2006 .

[20]  T. A. Butler,et al.  Effect of valence state on ICP-OES value assignment of SRM 3103a arsenic spectrometric solution. , 2006, Analytical chemistry.

[21]  F. Malz,et al.  Validation of quantitative NMR. , 2005, Journal of pharmaceutical and biomedical analysis.

[22]  M. Han,et al.  Determination of Dibutyltin in Sediments Using Isotope Dilution Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry , 2005 .

[23]  S. Hirata,et al.  Determination of inorganic oxyanions of As and Se by HPLC-ICPMS. , 2004, Talanta.

[24]  J. Caruso,et al.  Arsenic and its speciation analysis using high-performance liquid chromatography and inductively coupled plasma mass spectrometry. , 2004, Journal of chromatography. A.

[25]  Kevin A Francesconi,et al.  Determination of arsenic species: a critical review of methods and applications, 2000-2003. , 2004, The Analyst.

[26]  P. Pohl.  Hydride generation – recent advances in atomic emission spectrometry , 2004 .

[27]  Michael F Hughes,et al.  Arsenic toxicity and potential mechanisms of action. , 2002, Toxicology letters.

[28]  W. Goessler,et al.  Characterization of an algal extract by HPLC-ICP-MS and LC-electrospray MS for use in arsenosugar speciation studies , 2000 .

[29]  J. Szpunar,et al.  Bio-inorganic speciation analysis by hyphenated techniques. , 2000, The Analyst.

[30]  D. Vélez,et al.  Optimization of the solubilization, extraction and determination of inorganic arsenic [As(III) + (As(V)] in seafood products by acid digestion, solvent extraction and hydride generation atomic absorption spectrometry. , 1999, The Analyst.

[31]  W. Goessler,et al.  Arsenobetaine and other arsenic compounds in the National Research Council of Canada Certified Reference Materials DORM 1 and DORM 2 , 1998 .

[32]  C. Cámara,et al.  Comparison of three multivariate calibration methods as an approach to arsenic speciation by HG-AAS , 1997 .

[33]  W. Goessler,et al.  Can Humans Metabolize Arsenic Compounds to Arsenobetaine , 1997 .

[34]  A. Howard.  Boro)Hydride Techniques in Trace Element Speciation , 1997 .

[35]  J. Edmonds,et al.  Arsenic and Marine Organisms , 1996 .

[36]  M. Vahter.  Species differences in the metabolism of arsenic compounds , 1994 .

[37]  S. Hansen,et al.  Arsenic speciation in seafood samples with emphasis on minor constituents: an investigation using high-performance liquid chromatography with detection by inductively coupled plasma mass spectrometry , 1993 .

[38]  T. Kaise,et al.  The chemical form and acute toxicity of arsenic compounds in marine organisms , 1992 .

[39]  E. Larsen,et al.  Separation of arsenic species by ion-pair and ion exchange high performance liquid chromatography , 1992 .

[40]  D. Beauchemin,et al.  Determination of arsenic species by high-performance liquid chromatography-inductively coupled plasma mass spectrometry , 1989 .