Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL‐6 trans‐signalling

This study investigated the specific molecular mechanism and the roles of extracellular matrix protein Spondin 1 (SPON1) in the development of pancreatic ductal adenocarcinoma (PDAC).

[1]  N. Karamanos,et al.  Extracellular matrix-based cancer targeting. , 2021, Trends in molecular medicine.

[2]  R. Eils,et al.  Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin. , 2020, Cancer discovery.

[3]  A. Maitra,et al.  Pancreatic cancer stroma: an update on therapeutic targeting strategies , 2020, Nature Reviews Gastroenterology & Hepatology.

[4]  Yongfeng Ding,et al.  Identification of genes associated with gastric cancer survival and construction of a nomogram to improve risk stratification for patients with gastric cancer , 2020, Oncology letters.

[5]  Edward L. Giovannucci,et al.  Global Burden of 5 Major Types Of Gastrointestinal Cancer. , 2020, Gastroenterology.

[6]  Navid Shomali,et al.  Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations , 2020, Journal of Gastrointestinal Cancer.

[7]  T. Donahue,et al.  Pancreatic Cancer. , 2019, JAMA.

[8]  L. Shevde,et al.  The Tumor Microenvironment Innately Modulates Cancer Progression. , 2019, Cancer research.

[9]  H. Kocher,et al.  Pancreatic Cancer , 2019, Methods in Molecular Biology.

[10]  J. Scheller,et al.  Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses , 2018, Science Signaling.

[11]  J. Kleeff,et al.  Therapeutic developments in pancreatic cancer: current and future perspectives , 2018, Nature Reviews Gastroenterology & Hepatology.

[12]  T. Zhu,et al.  Biomarkers identified for prostate cancer patients through genome-scale screening , 2017, Oncotarget.

[13]  Jin Ding,et al.  The HLF/IL-6/STAT3 feedforward circuit drives hepatic stellate cell activation to promote liver fibrosis , 2017, Gut.

[14]  S. Rose-John,et al.  Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation , 2017, PLoS biology.

[15]  H. Blum,et al.  Trans-presentation of interleukin-6 by dendritic cells is required for priming pathogenic TH17 cells , 2016, Nature Immunology.

[16]  K. Strauch,et al.  Projections of cancer incidence and cancer‐related deaths in Germany by 2020 and 2030 , 2016, Cancer medicine.

[17]  John J Murphy,et al.  STAT5 in Cancer and Immunity. , 2016, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[18]  Wei Dai,et al.  microRNA-506 regulates proliferation, migration and invasion in hepatocellular carcinoma by targeting F-spondin 1 (SPON1). , 2015, American journal of cancer research.

[19]  T. Dong,et al.  Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma. , 2015, Biochemical and biophysical research communications.

[20]  Benjamin D. Smith,et al.  Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. , 2014, Cancer research.

[21]  Robert C. Green,et al.  Genome-wide association study of the rate of cognitive decline in Alzheimer's disease , 2014, Alzheimer's & Dementia.

[22]  Mukut Sharma,et al.  IL-6 activates STAT5 in T cells. , 2012, Cytokine.

[23]  M. Fukuda,et al.  Faculty Opinions recommendation of ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). , 2011 .

[24]  Yuan Zhang,et al.  ECM1 controls TH2 cell egress from lymph nodes through re-expression of S1P1 , 2011, Nature Immunology.

[25]  M. Colombo,et al.  Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis , 2010, Cancer and Metastasis Reviews.

[26]  I. Tsai,et al.  F‐spondin plays a critical role in murine neuroblastoma survival by maintaining IL‐6 expression , 2009, Journal of neurochemistry.

[27]  Tatsuo Suzuki,et al.  Proteolysis and membrane capture of F-spondin generates combinatorial guidance cues from a single molecule , 2007, The Journal of cell biology.

[28]  Nilesh J Samani,et al.  Genetic Dissection of a Blood Pressure Quantitative Trait Locus on Rat Chromosome 1 and Gene Expression Analysis Identifies SPON1 As a Novel Candidate Hypertension Gene , 2007, Circulation research.

[29]  Elizabeth A. Repasky,et al.  VSGP/F-Spondin: A New Ovarian Cancer Marker , 2005, Tumor Biology.

[30]  P. Heinrich,et al.  Principles of interleukin (IL)-6-type cytokine signalling and its regulation. , 2003, The Biochemical journal.

[31]  Josephine C. Adams,et al.  The thrombospondin type 1 repeat (TSR) superfamily: Diverse proteins with related roles in neuronal development , 2000, Developmental dynamics : an official publication of the American Association of Anatomists.

[32]  S. Scherer,et al.  Accumulation of F-Spondin in Injured Peripheral Nerve Promotes the Outgrowth of Sensory Axons , 1998, The Journal of Neuroscience.