High‐dose treatment for malignant rhabdoid tumor of the kidney: No evidence for improved survival—The Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) experience

Malignant rhabdoid tumor of the kidney (MRTK) is the most aggressive childhood renal tumor with overall survival (OS) rates ranging from 22% to 42%. Whether high‐dose chemotherapy with autologous stem‐cell transplantation (HDSCT) in an intensive first‐line treatment offers additional benefit is an ongoing discussion.

[1]  P. Houghton,et al.  Initial testing (stage 1) of tazemetostat (EPZ‐6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program , 2017, Pediatric blood & cancer.

[2]  A. Ferrari,et al.  Outcome of extracranial malignant rhabdoid tumours in children registered in the European Paediatric Soft Tissue Sarcoma Study Group Non-Rhabdomyosarcoma Soft Tissue Sarcoma 2005 Study-EpSSG NRSTS 2005. , 2016, European journal of cancer.

[3]  Roland Eils,et al.  Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. , 2016, Cancer cell.

[4]  A. Agaimy The Expanding Family of SMARCB1(INI1)-deficient Neoplasia: Implications of Phenotypic, Biological, and Molecular Heterogeneity , 2014, Advances in anatomic pathology.

[5]  I. Leuschner,et al.  Malignant rhabdoid tumor of the kidney: significantly improved response to pre-operative treatment intensified with doxorubicin. , 2014, Cancer genetics.

[6]  C. Roberts,et al.  Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth. , 2014, Cancer genetics.

[7]  M. Kool,et al.  Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1 , 2014, International journal of cancer.

[8]  Shengmei Zhou,et al.  High dose alkylator therapy for extracranial malignant rhabdoid tumors in children , 2014, Pediatric blood & cancer.

[9]  O. Witt,et al.  High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT): a report from the European Rhabdoid Registry (EU-RHAB) , 2014, Bone Marrow Transplantation.

[10]  S. Keir,et al.  Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ‐26481585), by the Pediatric Preclinical Testing Program , 2014, Pediatric blood & cancer.

[11]  N Graf,et al.  Clear cell sarcomas of the kidney registered on International Society of Pediatric Oncology (SIOP) 93-01 and SIOP 2001 protocols: a report of the SIOP Renal Tumour Study Group. , 2013, European journal of cancer.

[12]  Chiang-Ching Huang,et al.  Study of the gene expression and microRNA expression profiles of malignant rhabdoid tumors originated in the brain (AT/RT) and in the kidney (RTK) , 2013, Child's Nervous System.

[13]  R. Vibhakar,et al.  Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells , 2012, Journal of Neuro-Oncology.

[14]  K. Pritchard-Jones,et al.  Malignant rhabdoid tumours of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: A report of the SIOP renal tumour study group , 2011, Pediatric blood & cancer.

[15]  C. Rübe,et al.  Update on Relapses in Unilateral Nephroblastoma Registered in 3 Consecutive SIOP/GPOH Studies – A Report from the GPOH-Nephroblastoma Study Group , 2011, Klinische Padiatrie.

[16]  M. Garrè,et al.  Role of high‐dose chemotherapy (HDCT) in treatment of atypical teratoid/rhabdoid tumors (AT/RTs) , 2010, Pediatric blood & cancer.

[17]  R. Siebert,et al.  Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome. , 2010, American journal of human genetics.

[18]  I. Leuschner,et al.  Rhabdoid tumors in children: prognostic factors in 70 patients diagnosed in Germany. , 2008, Oncology reports.

[19]  N. Breslow,et al.  Rhabdoid tumor of the kidney in the National Wilms' Tumor Study: age at diagnosis as a prognostic factor. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[20]  M. Stöckle,et al.  Wilms' tumor in adults: results of the Society of Pediatric Oncology (SIOP) 93-01/Society for Pediatric Oncology and Hematology (GPOH) Study. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[21]  Dieter Harms,et al.  Revised International Society of Paediatric Oncology (SIOP) working classification of renal tumors of childhood. , 2002, Medical and pediatric oncology.

[22]  F. Salamanca-Gómez [Childhood cancer registry]. , 2011, Revista medica del Instituto Mexicano del Seguro Social.