In search of the source of factor VIII.

The cellular site of synthesis of factor VIII in the circulation has long been disputed, but 2 papers in this issue of Blood by Fahs et al[1][1] and Everett et al[2][2] finally identify the cell type that makes factor VIII in the liver and, by implication, in the rest of the body. To understand why

[1]  D. Ginsburg,et al.  Murine coagulation factor VIII is synthesized in endothelial cells. , 2014, Blood.

[2]  R. Montgomery,et al.  A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII. , 2014, Blood.

[3]  C. Peschel,et al.  Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease. , 2014, Blood.

[4]  Amanda M. Schmidt,et al.  Inhibition of Calcineurin Abrogates While Inhibition of mTOR Promotes Regulatory T Cell Expansion and Graft-Versus-Host Disease Protection by IL-2 in Allogeneic Bone Marrow Transplantation , 2014, PloS one.

[5]  K. Peerlinck,et al.  Human liver sinusoidal endothelial cells but not hepatocytes contain factor VIII , 2014, Journal of thrombosis and haemostasis : JTH.

[6]  A. Heine,et al.  Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis? , 2013, Blood.

[7]  S. Held,et al.  The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo. , 2013, Blood.

[8]  P. Fagone,et al.  Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant. , 2013, Blood.

[9]  L. Hellman,et al.  Secretion of coagulant factor VIII activity and antigen by in vitro cultivated rat liver sinusoidal endothelial cells , 1989, British journal of haematology.

[10]  R. Lawn,et al.  Distribution of factor VIII mRNA and antigen in human liver and other tissues , 1985, Nature.

[11]  B. Keyt,et al.  Structure of human factor VIII , 1984, Nature.

[12]  C. Zukoski,et al.  Plasma factor VIII synthesis and control as revealed by canine organ transplantation. , 1971, The American journal of physiology.