An Ions-Medicated Single Molecular Multi-functional DNA Cascade Logic Circuit and Signal Amplifier Model

In this paper, a single molecular multi-functional DNA cascade logic circuit and signal amplifier model was demonstrated by two single molecular multi-functional ions DNA probe(SMIP) to detect environment mercury and silver ion pollution, these two SMIP random coil structures turned into different hairpin-like structures with T-Hg\(^{2+}\)-T or C-Ag\(^{+}\)-C via inputting mercury and silver ions, then, use the SMIP structure “OR” and “AND” logic gate and unimolecular mulfunctional DNA logic amplifier model (UMDA). Finally, we proved the feasibility of our model by PAGE and fluorescence alteration.