Comparison of Cross-Linked Branched and Linear Poly(ethylene imine) Microgel Microstructures and Their Impact in Antimicrobial Behavior, Copper Chelation, and Carbon Dioxide Capture

Poly(ethylene imine) (PEI) is a cationic polymer that is commercially available in linear (LPEI) and branched (BPEI) architectures for both biological and environmental applications. By coupling the LPEI or BPEI with divinyl sulfone, crosslinked PEI is formed and has been researched for its same robust properties as traditional PEI, but with a rigid, insoluble structure. Herein, we present the first direct comparison of crosslinked linear PEI microgels and branched PEI microgels (LPM and BPM respectively) in both their intrinsic characteristics, such as morphology, surface charge, and surface chemistry, as well as their applications in antimicrobial activity, copper chelation, and CO2 capture. The Cu(II) adsorption capacity of the LPMs is larger than their branched counterparts and their performance is comparable to that of similar materials with a maximum adsorption capacity of 86.8 mg/g. LPM and BPM shows no significant inhibition in bacterial growth compared to a positive control (culture inoculated wi...

[1]  A. Domb,et al.  Crosslinked colloids with cyclopropenium cations , 2018, Journal of Polymer Science Part A: Polymer Chemistry.

[2]  Peng Li,et al.  Hydrogel Effects Rapid Biofilm Debridement with ex situ Contact-Kill to Eliminate Multidrug Resistant Bacteria in vivo. , 2018, ACS Applied Materials and Interfaces.

[3]  Jung-Hyun Kim,et al.  Fully organic CO2 absorbent obtained by a Schiff base reaction between branched poly(ethyleneimine) and glutaraldehyde , 2018, Korean Journal of Chemical Engineering.

[4]  S. Zaidi,et al.  Copper removal from industrial wastewater: A comprehensive review , 2017 .

[5]  S. Chuang,et al.  Enhancing Degradation Resistance of Polyethylenimine for CO2 Capture with Cross-Linked Poly(vinyl alcohol) , 2017 .

[6]  J. Bi,et al.  Atmospheric evidence for a global secular increase in carbon isotopic discrimination of land photosynthesis , 2017, Proceedings of the National Academy of Sciences.

[7]  M. Nydén,et al.  Polyethyleneimine functionalized mesoporous diatomite particles for selective copper recovery from aqueous media , 2017 .

[8]  D. Wei,et al.  Rapid removal of Pb(II) from aqueous solution using branched polyethylenimine enhanced magnetic carboxymethyl chitosan optimized with response surface methodology , 2017, Scientific Reports.

[9]  N. Sahiner,et al.  Can PEI microgels become biocompatible upon betainization? , 2017, Materials science & engineering. C, Materials for biological applications.

[10]  S. H. Kim,et al.  Development of Crosslinked PEI Solid Adsorbents for CO2 Capture , 2017 .

[11]  Hongbo Du,et al.  Polyethylenimine Applications in Carbon Dioxide Capture and Separation: From Theoretical Study to Experimental Work , 2017 .

[12]  Caixia Wang,et al.  Structural insights into the coordination and selective extraction of copper(II) by tertiary amine ligands derived from 2-aminomethylpyridine , 2017 .

[13]  H. Luo,et al.  A facile, sensitive, and rapid spectrophotometric method for copper(II) ion detection in aqueous media using polyethyleneimine , 2017 .

[14]  M. Diudea,et al.  Linear and Branched PEIs (Polyethylenimines) and Their Property Space , 2016, International journal of molecular sciences.

[15]  M. Zielińska,et al.  Bacterial communities in full-scale wastewater treatment systems , 2016, World journal of microbiology & biotechnology.

[16]  Jingjing Wang,et al.  Enhanced selective removal of Cu(II) from aqueous solution by novel polyethylenimine-functionalized ion imprinted hydrogel: Behaviors and mechanisms. , 2015, Journal of hazardous materials.

[17]  H. Al‐Lohedan,et al.  The synthesis of desired functional groups on PEI microgel particles for biomedical and environmental applications , 2015 .

[18]  Christopher W. Jones,et al.  Amine-Oxide Hybrid Materials for CO2 Capture from Ambient Air. , 2015, Accounts of chemical research.

[19]  Scott M. Grayson,et al.  The Synthesis of Cyclic Poly(ethylene imine) and Exact Linear Analogues: An Evaluation of Gene Delivery Comparing Polymer Architectures. , 2015, Journal of the American Chemical Society.

[20]  A. Domb,et al.  Quaternary ammonium polyethylenimine nanoparticles for treating bacterial contaminated water. , 2015, Colloids and surfaces. B, Biointerfaces.

[21]  A. Steinfeld,et al.  Fast and reversible direct CO2 capture from air onto all-polymer nanofibrillated cellulose-polyethylenimine foams. , 2015, Environmental science & technology.

[22]  R. Teixeira-Santos,et al.  Polyethyleneimine and polyethyleneimine-based nanoparticles: novel bacterial and yeast biofilm inhibitors. , 2014, Journal of medical microbiology.

[23]  Ruixue Zhu,et al.  Locations of methanol in methanol-containing AOT reverse micelles revealed by photophysics of IR125 , 2013 .

[24]  Chih-Hung Huang,et al.  A Review of CO2 Capture by Absorption and Adsorption , 2012 .

[25]  Daniel K. Bonner,et al.  Crosslinked linear polyethylenimine enhances delivery of DNA to the cytoplasm. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[26]  K. Kuroda,et al.  Poly(ethylene imine)s as antimicrobial agents with selective activity. , 2012, Macromolecular bioscience.

[27]  Philip G. Jessop,et al.  Support-Free Porous Polyamine Particles for CO2 Capture. , 2012, ACS macro letters.

[28]  K. R. Ram,et al.  Linear PEI nanoparticles: efficient pDNA/siRNA carriers in vitro and in vivo. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[29]  A. Samanta,et al.  Post-Combustion CO2 Capture Using Solid Sorbents: A Review , 2012 .

[30]  Christopher W. Jones,et al.  Poly(allylamine)–Mesoporous Silica Composite Materials for CO2 Capture from Simulated Flue Gas or Ambient Air , 2011 .

[31]  Jiachao Zhang,et al.  PEI-grafted magnetic porous powder for highly effective adsorption of heavy metal ions , 2011 .

[32]  Shuixia Chen,et al.  Preparation of an ion-imprinted fiber for the selective removal of Cu2+. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[33]  E. Cukrowska,et al.  Development and application of cross-linked polyethylenimine for trace metal and metalloid removal from mining and industrial wastewaters , 2011 .

[34]  J. Leroux,et al.  Reverse micelles from amphiphilic branched polymers , 2010 .

[35]  T. Zhu,et al.  Adsorption of carbon dioxide using polyethyleneimine modified silica gel , 2010 .

[36]  L. Lv,et al.  Selective removal of Cu(II) ions by using cation-exchange resin-supported polyethyleneimine (PEI) nanoclusters. , 2010, Environmental science & technology.

[37]  U. Schubert,et al.  Linear Poly(ethylene imine)s by Acidic Hydrolysis of Poly(2-oxazoline)s: Kinetic Screening, Thermal Properties, and Temperature-Induced Solubility Transitions , 2010 .

[38]  Abraham J Domb,et al.  Surface antimicrobial activity and biocompatibility of incorporated polyethylenimine nanoparticles. , 2008, Biomaterials.

[39]  S. Chakraborty,et al.  Uptake and desorption of copper ion using functionalized polymer coated silica gel in aqueous environment , 2007 .

[40]  Yong Zhu,et al.  Studies on the preparation and antibacterial properties of quaternized polyethyleneimine , 2007, Journal of biomaterials science. Polymer edition.

[41]  M. Taher,et al.  Application of a new water-soluble polyethylenimine polymer sorbent for simultaneous separation and preconcentration of trace amounts of copper and manganese and their determination by atomic absorption spectrophotometry , 2006 .

[42]  A. Klibanov,et al.  Immobilized N-alkylated polyethylenimine avidly kills bacteria by rupturing cell membranes with no resistance developed. , 2005, Biotechnology and bioengineering.

[43]  C. Goddard,et al.  A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo , 2003, Gene Therapy.

[44]  V. Kislenko,et al.  Complex formation of polyethyleneimine with copper(II), nickel(II), and cobalt(II) ions , 2002 .

[45]  Alexander M. Klibanov,et al.  Designing surfaces that kill bacteria on contact , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[46]  I. Helander,et al.  Permeabilizing action of polyethyleneimine on Salmonella typhimurium involves disruption of the outer membrane and interactions with lipopolysaccharide. , 1998, Microbiology.

[47]  H. Alakomi,et al.  Polyethyleneimine is an effective permeabilizer of gram-negative bacteria. , 1997, Microbiology.

[48]  C. Benoist,et al.  A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. , 1996, Human gene therapy.

[49]  Markus Antonietti,et al.  Micellization of strongly segregated block copolymers , 1996 .

[50]  D. Scherman,et al.  A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Shiro Kobayashi,et al.  Viscosity Behaviors and Gel Properties of Linear and Branched Polyethylenimines: Effects of Micro-Structures , 1990, Polymer Journal.

[52]  Shiro Kobayashi,et al.  Chelating properties of linear and branched poly(ethylenimines) , 1987 .

[53]  T. Takagishi,et al.  Binding of cupric ion by crosslinked polyethylenimine , 1985 .

[54]  Jonathan J. Cole,et al.  INTERACTIONS BETWEEN BACTERIA AND ALGAE IN AQUATIC ECOSYSTEMS , 1982 .