SIRT1 directly activates autophagy in human chondrocytes

[1]  Fei Huang,et al.  The New Role of Sirtuin1 in Human Osteoarthritis Chondrocytes by Regulating Autophagy , 2019, Cartilage.

[2]  R. Liu-Bryan,et al.  Effect of nicotinamide riboside on cartilage matrix homeostasis , 2019, Osteoarthritis and Cartilage.

[3]  George Bou-Gharios,et al.  Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300 , 2018, Experimental & Molecular Medicine.

[4]  Wencai Sun,et al.  miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. , 2017, Experimental and therapeutic medicine.

[5]  K. Yudoh,et al.  The Nicotinamide Adenine Dinucleotide (NAD)-Dependent Deacetylase Sirtuin-1 Regulates Chondrocyte Energy Metabolism through the Modulation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Osteoarthritis(OA) , 2017 .

[6]  Chen Zhang,et al.  Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia , 2016, Protein & Cell.

[7]  V. Lefebvre,et al.  Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes , 2016, Aging cell.

[8]  Ming Gong,et al.  Reciprocal regulation by hypoxia-inducible factor-2α and the NAMPT-NAD(+)-SIRT axis in articular chondrocytes is involved in osteoarthritis. , 2015, Osteoarthritis and cartilage.

[9]  D. Klionsky,et al.  Post‐translationally‐modified structures in the autophagy machinery: an integrative perspective , 2015, The FEBS journal.

[10]  A. Carr,et al.  Osteoarthritis , 2015, The Lancet.

[11]  M. Lotz,et al.  The Relationship of Autophagy Defects to Cartilage Damage During Joint Aging in a Mouse Model , 2015, Arthritis & rheumatology.

[12]  R. Deng,et al.  Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth , 2015, Nature Communications.

[13]  Ashok Kumar,et al.  Detecting cathepsin activity in human osteoarthritis via activity-based probes , 2015, Arthritis Research & Therapy.

[14]  J. Lippincott-Schwartz,et al.  Deacetylation of nuclear LC3 drives autophagy initiation under starvation. , 2015, Molecular cell.

[15]  Y. Rampersaud,et al.  PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage , 2015, Annals of the rheumatic diseases.

[16]  F. Flamigni,et al.  Beneficial effect of 3-hydroxytyrosol on chondrocytes exposed to oxidative stress , 2014 .

[17]  J. Pelletier,et al.  Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis , 2014, Annals of the rheumatic diseases.

[18]  D. Sinclair,et al.  Small molecule SIRT1 activators for the treatment of aging and age-related diseases. , 2014, Trends in pharmacological sciences.

[19]  M. Liebergall,et al.  Set7/9 Impacts COL2A1 Expression Through Binding and Repression of SirT1 Histone Deacetylation , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  J. Brumell,et al.  Bacteria–autophagy interplay: a battle for survival , 2014, Nature Reviews Microbiology.

[21]  T. Suuronen,et al.  Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders. , 2013, Cellular signalling.

[22]  T. Matsushita,et al.  Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice , 2013, Annals of the rheumatic diseases.

[23]  T. Matsushita,et al.  The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[24]  J. Nyman,et al.  Silent information regulator (Sir)T1 inhibits NF‐κB signaling to maintain normal skeletal remodeling , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[25]  Sang-Youel Park,et al.  SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes. , 2013, Osteoarthritis and cartilage.

[26]  J. Edwards,et al.  Aging mechanisms in arthritic disease. , 2012, Discovery medicine.

[27]  J. Baur,et al.  Are sirtuins viable targets for improving healthspan and lifespan? , 2012, Nature Reviews Drug Discovery.

[28]  Eun Jin Lee,et al.  75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes. , 2012, Arthritis and rheumatism.

[29]  C. Sanchez,et al.  Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice , 2012, Annals of the rheumatic diseases.

[30]  D. Rubinsztein,et al.  Autophagy and Aging , 2011, Cell.

[31]  Andrea Ballabio,et al.  TFEB Links Autophagy to Lysosomal Biogenesis , 2011, Science.

[32]  T. Matsushita,et al.  Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[33]  L. Guarente,et al.  Sirtuins at a glance , 2011, Journal of Cell Science.

[34]  Eun Jin Lee,et al.  SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. , 2010, Arthritis and rheumatism.

[35]  M. Lotz,et al.  Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. , 2010, Arthritis and rheumatism.

[36]  C. Whitaker.  The battle for survival. , 1949, The Illinois medical journal.

[37]  R. Terkeltaub,et al.  Emerging regulators of the inflammatory process in osteoarthritis , 2015, Nature Reviews Rheumatology.

[38]  J. Lebow.  The integrative perspective. , 2014 .

[39]  T. Ueno,et al.  LC3 and Autophagy. , 2008, Methods in molecular biology.