Reduced 3H-Dopamine Uptake by Blood Platelets in Patients with Prolactin-Secreting Pituitary Adenoma

Uptake of 3H-Dopamine by blood platelets was found to be significantly reduced in eight patients with prolactin (PRL) secreting pituitary adenoma in comparison to normal subjects (27.91±5.01 nmol/1011 platelets vs. 73.42±4.99 nmol/1011 platelets, p<0.001). Since platelet monoamine uptake seems to reflect brain monoaminergic activity, the reduction of dopamine uptake (DAU) in our hyperprolactinemic subjects suggests a defective dopaminergic neurotransmission in patients with PRL-secreting tumors.

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