Mechanisms of action of Fu Fang Gang Liu liquid in treating condyloma acuminatum by network pharmacology and experimental validation

[1]  M. Kanehisa,et al.  KEGG for taxonomy-based analysis of pathways and genomes , 2022, Nucleic Acids Res..

[2]  Xinyu Jiang,et al.  The mechanism of action of the combination of Astragalus membranaceus and Ligusticum chuanxiong in the treatment of ischemic stroke based on network pharmacology and molecular docking. , 2022, Medicine.

[3]  Jingwen Chen,et al.  Prediction and validation of potential molecular targets for the combination of Astragalus membranaceus and Angelica sinensis in the treatment of atherosclerosis based on network pharmacology , 2022, Medicine.

[4]  X. Zhang,et al.  Uncovering the mechanism of Huanglian-Wuzhuyu herb pair in treating nonalcoholic steatohepatitis based on network pharmacology and experimental validation. , 2022, Journal of ethnopharmacology.

[5]  Yuanjun Yin,et al.  Based on network pharmacology and in vitro experiments to prove the effective inhibition of myocardial fibrosis by Buyang Huanwu decoction , 2022, Bioengineered.

[6]  W. Wang,et al.  Hiplot: a comprehensive and easy-to-use web service boosting publication-ready biomedical data visualization , 2022, bioRxiv.

[7]  N. Bhari,et al.  Asian guidelines for condyloma acuminatum. , 2022, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[8]  K. Zeng,et al.  Identification of novel biomarkers and key pathways of condyloma acuminata. , 2022, Genomics.

[9]  Yi Cheng,et al.  Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway , 2021, Frontiers in Oncology.

[10]  D. Barh,et al.  Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics , 2021, Biomolecules.

[11]  Xiaochen Bo,et al.  clusterProfiler 4.0: A universal enrichment tool for interpreting omics data , 2021, Innovation.

[12]  Yi Zhao,et al.  KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis , 2021, Nucleic Acids Res..

[13]  Z. Dong,et al.  Periplogenin suppresses the growth of esophageal squamous cell carcinoma in vitro and in vivo by targeting STAT3 , 2021, Oncogene.

[14]  Miranda Thomas,et al.  Human papillomavirus E6 and E7: What remains? , 2021, Tumour virus research.

[15]  Alix Warburton,et al.  Persistent Human Papillomavirus Infection , 2021, Viruses.

[16]  T. Jin,et al.  Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation , 2021, Frontiers in Public Health.

[17]  Naiqiang Zhu,et al.  Molecular mechanism of the anti-inflammatory effects of Sophorae Flavescentis Aiton identified by network pharmacology , 2021, Scientific Reports.

[18]  Peter B. McGarvey,et al.  UniProt: the universal protein knowledgebase in 2021 , 2020, Nucleic Acids Res..

[19]  David S. Goodsell,et al.  RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences , 2020, Nucleic Acids Res..

[20]  Benjamin A. Shoemaker,et al.  PubChem in 2021: new data content and improved web interfaces , 2020, Nucleic Acids Res..

[21]  Ling Guo,et al.  Mechanism of Action of Periplogenin on Nasopharyngeal Carcinoma Based on Network Pharmacology and Experimental Study of Vitamin E Coupled with Periplogenin Self-Assembled Nano-Prodrug for Nasopharyngeal Carcinoma. , 2020, Journal of biomedical nanotechnology.

[22]  R. Gilson,et al.  2019 IUSTI‐Europe guideline for the management of anogenital warts , 2020, Journal of the European Academy of Dermatology and Venereology : JEADV.

[23]  A. Corvalán,et al.  Human Papillomavirus 16 E7 Promotes EGFR/PI3K/AKT1/NRF2 Signaling Pathway Contributing to PIR/NF-κB Activation in Oral Cancer Cells , 2020, Cancers.

[24]  Rita Kundu,et al.  Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy , 2020, Frontiers in Microbiology.

[25]  F. Sanz,et al.  The DisGeNET knowledge platform for disease genomics: 2019 update , 2019, Nucleic Acids Res..

[26]  Minoru Kanehisa,et al.  Toward understanding the origin and evolution of cellular organisms , 2019, Protein science : a publication of the Protein Society.

[27]  Olivier Michielin,et al.  SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules , 2019, Nucleic Acids Res..

[28]  K. Zeng,et al.  5-aminolevulinic acid photodynamic therapy reduces HPV viral load via autophagy and apoptosis by modulating Ras/Raf/MEK/ERK and PI3K/AKT pathways in HeLa cells. , 2019, Journal of photochemistry and photobiology. B, Biology.

[29]  Damian Szklarczyk,et al.  STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets , 2018, Nucleic Acids Res..

[30]  Wei Zhang,et al.  ETCM: an encyclopaedia of traditional Chinese medicine , 2018, Nucleic Acids Res..

[31]  Jian-Qin Wang,et al.  Expression of Caspase 8 and phospho-Akt in condyloma acuminatum lesions , 2017 .

[32]  Xuemin Qiu,et al.  Traditional Chinese medicine for human papillomavirus (HPV) infections: A systematic review. , 2017, Bioscience trends.

[33]  Xia Wang,et al.  PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database , 2017, Nucleic Acids Res..

[34]  Jiangnan Yu,et al.  Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfide bond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy , 2017, Drug delivery.

[35]  Nicolas Wentzensen,et al.  Carcinogenic human papillomavirus infection , 2016, Nature Reviews Disease Primers.

[36]  Huiyun Zhang,et al.  Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation , 2016, Oncotarget.

[37]  L. Denny.  MANAGEMENT OF HPVAND ASSOCIATED CERVICAL LESIONS ( L DENNY , SECTION EDITOR ) Epidemiology and Burden of Disease Associated with HPV Infection , 2016 .

[38]  Xianling Cong,et al.  Correlation of human papillomavirus types with clinical features of patients with condyloma acuminatum in China , 2016, International journal of dermatology.

[39]  Yuan-wen Wang,et al.  Tumor targeted delivery of octreotide-periplogenin conjugate: Synthesis, in vitro and in vivo evaluation. , 2016, International journal of pharmaceutics.

[40]  M. Ling,et al.  The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses , 2015, Molecular Cancer.

[41]  Eric O'Neill,et al.  PI3K/Akt-mediated regulation of p53 in cancer. , 2014, Biochemical Society transactions.

[42]  Xin He,et al.  Periplocymarin is a potential natural compound for drug development: highly permeable with absence of P‐glycoprotein efflux and cytochrome P450 inhibitions , 2014, Biopharmaceutics & drug disposition.

[43]  Wei Zhou,et al.  TCMSP: a database of systems pharmacology for drug discovery from herbal medicines , 2014, Journal of Cheminformatics.

[44]  Mario Schelhaas,et al.  Concepts of papillomavirus entry into host cells. , 2014, Current opinion in virology.

[45]  C. Chen,et al.  Phosphatidylinositol 3-kinase signaling as a therapeutic target for cervical cancer. , 2013, Current cancer drug targets.

[46]  M. Wagner,et al.  Systematic review of the incidence and prevalence of genital warts , 2013, BMC Infectious Diseases.

[47]  Dingquan Yang,et al.  Expressions of phosphatidylinositol 3 kinase and phosphorylated Akt in condyloma acuminatum and cervical squamous cell carcinoma , 2011 .

[48]  C. Catricalà,et al.  Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma , 2011, Journal of experimental & clinical cancer research : CR.

[49]  C. Meijer,et al.  PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro , 2011, Molecular Cancer.

[50]  P. Delvenne,et al.  Mechanisms of cell entry by human papillomaviruses: an overview , 2010, Virology Journal.

[51]  A. Braca,et al.  Pro-apoptotic and cytostatic activity of naturally occurring cardenolides , 2009, Cancer Chemotherapy and Pharmacology.

[52]  A. Contreras-Paredes,et al.  E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway. , 2009, Virology.

[53]  Robert A Newman,et al.  Cardiac glycosides as novel cancer therapeutic agents. , 2008, Molecular interventions.

[54]  D. McCance,et al.  Human papillomavirus type 16 E7 up-regulates AKT activity through the retinoblastoma protein. , 2006, Cancer research.

[55]  Y. Bang,et al.  Human papillomavirus 16 E5 up-regulates the expression of vascular endothelial growth factor through the activation of epidermal growth factor receptor, MEK/ ERK1,2 and PI3K/Akt , 2006, Cellular and Molecular Life Sciences CMLS.

[56]  D. Pim,et al.  Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A , 2005, Oncogene.

[57]  Xian Xu,et al.  [Clinical efficacy of compound periploca liquid in treating condyloma acuminatum and its effect on human papilloma virus DNA expression in vitro]. , 2005, Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.

[58]  J. Doorbar.  The papillomavirus life cycle. , 2005, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[59]  Michelle S. Longworth,et al.  Pathogenesis of Human Papillomaviruses in Differentiating Epithelia , 2004, Microbiology and Molecular Biology Reviews.

[60]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[61]  M. Scheffner,et al.  The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53 , 1993, Cell.

[62]  J. Woodgett,et al.  Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. , 1991, European journal of biochemistry.

[63]  K. Münger,et al.  Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. , 1989, The EMBO journal.

[64]  H. Itokawa,et al.  Studies on chemical constituents of antitumor fraction from Periploca sepium BGE. I. , 1987, Chemical & pharmaceutical bulletin.

[65]  S. Staal.  Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[66]  Tsippi Iny Stein,et al.  The GeneCards Suite , 2021, Practical Guide to Life Science Databases.

[67]  Practical Guide to Life Science Databases , 2021 .

[68]  M. Aoki,et al.  Oncogenic Roles of the PI3K/AKT/mTOR Axis. , 2017, Current topics in microbiology and immunology.

[69]  A. Hopkins.  Network pharmacology , 2007, Nature Biotechnology.

[70]  Susumu Goto,et al.  KEGG: Kyoto Encyclopedia of Genes and Genomes , 2000, Nucleic Acids Res..