Children of alcoholics exhibit attenuated cognitive impairment during an ethanol challenge.

In an attempt to identify markers potentially related to the development of problem drinking, we examined cognitive functioning in children of alcoholics (COAs) and children of nonalcoholics, both while sober and after consuming 0.85 ml/kg of ethanol. Consonant with previous research indicating that COAs exhibit less intense responses to alcohol, we predicted that COAs would experience attenuated cognitive deficits while intoxicated. Male (n = 71) and female (n = 29) college students completed tests of contextual and rote memory recall in a repeated-measures design. Findings indicated that intoxication impaired both memory and attentional capacities, and that COAs exhibited attenuated cognitive deficits relative to children of nonalcoholics. Results were consistent with previous research demonstrating attenuated responses to alcohol in COAs. Potential mechanisms for the pathogenesis of problem drinking are discussed.

[1]  V. Pollock.  Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics. , 1992, The American journal of psychiatry.

[2]  M L Selzer,et al.  A self-administered Short Michigan Alcoholism Screening Test (SMAST). , 1975, Journal of studies on alcohol.

[3]  P. Zelazo,et al.  Acute alcohol intoxication and cognitive functioning. , 1990, Journal of studies on alcohol.

[4]  V. Hesselbrock,et al.  P3 amplitudes in two distinct tasks are decreased in young men with a history of paternal alcoholism. , 1987, Alcohol.

[5]  C. Ehlers,et al.  EEG fast frequency activity in the sons of alcoholics , 1990, Biological Psychiatry.

[6]  R. Rose,et al.  Estimation of blood alcohol concentrations in young male drinkers. , 1991, Alcoholism, clinical and experimental research.

[7]  D. Fishbain,et al.  Manic-depressive illness associated with Turner's syndrome mosaicism. , 1981, The Journal of nervous and mental disease.

[8]  K. Sher,et al.  Reports of paternal alcoholism: reliability across siblings. , 1986, Addictive behaviors.

[9]  M. Earleywine,et al.  Sensation seeking explains the relation between behavioral disinhibition and alcohol consumption. , 1991, Addictive behaviors.

[10]  T M Itil,et al.  Electroencephalograms in children of alcoholic fathers. , 1982, Psychophysiology.

[11]  M. Schuckit,et al.  A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls. , 1988, Archives of general psychiatry.

[12]  M. Schuckit.  Low level of response to alcohol as a predictor of future alcoholism. , 1994, The American journal of psychiatry.

[13]  E. Noble,et al.  Neuropsychological differences between sons of active alcoholic and non-alcoholic fathers. , 1995, Alcohol and alcoholism.

[14]  D. W. Goodwin,et al.  The EEG after alcohol administration in men at risk for alcoholism. , 1983, Archives of general psychiatry.

[15]  M. Earleywine,et al.  Distraction does not impair memory during intoxication: support for the attention-allocation model. , 1995, Journal of studies on alcohol.

[16]  D. W. Goodwin,et al.  A prospective study of young men at high risk for alcoholism: neuropsychological assessment. , 1985, Alcoholism, clinical and experimental research.

[17]  A. Alterman,et al.  Learning achievement in sons of alcoholics. , 1984, Alcoholism, clinical and experimental research.

[18]  C. Nagoshi,et al.  Influence of family alcoholism history on alcohol metabolism, sensitivity, and tolerance. , 1987, Alcoholism, clinical and experimental research.

[19]  D. Newlin,et al.  Alcohol challenge with sons of alcoholics: a critical review and analysis. , 1990, Psychological bulletin.

[20]  C. F. Bond,et al.  Social and behavioral consequences of alcohol consumption and expectancy: a meta-analysis. , 1986, Psychological bulletin.

[21]  E. S. Parker,et al.  Alcohol and Memory: Retrieval Processes. , 1978 .

[22]  A. Alterman,et al.  Adolescent sons of alcoholics: neuropsychological and personality characteristics. , 1984, Alcoholism, clinical and experimental research.

[23]  M. Schuckit,et al.  Differences in muscle-tension response to ethanol in young men with and without family histories of alcoholism. , 1981, Journal of studies on alcohol.

[24]  C. Steele,et al.  The Two Faces of Alcohol Myopia: Attentional Mediation of Psychological Stress , 1990 .

[25]  R. Levenson,et al.  Greater reinforcement from alcohol for those at risk: parental risk, personality risk, and sex. , 1987, Journal of abnormal psychology.

[26]  R. Levenson,et al.  Risk for Alcoholism and Individual Differences in the Stress-Response-Dampening Effect of Alcohol , 1982 .

[27]  M. Sayette.  An appraisal-disruption model of alcohol's effects on stress responses in social drinkers. , 1993, Psychological bulletin.

[28]  P. Satz,et al.  Neuropsychological functioning in sons of active alcoholic, recovering alcoholic, and social drinking fathers. , 1997, Alcohol.

[29]  R. Pihl,et al.  Effects of alcohol on psychophysiological hyperreactivity to nonaversive and aversive stimuli in men at high risk for alcoholism. , 1990, Journal of abnormal psychology.

[30]  R Rawlings,et al.  Auditory recovery function and P3 in boys at high risk for alcoholism. , 1987, Alcohol.

[31]  T. O. Nelson,et al.  Effects of alcohol intoxication on metamemory and on retrieval from long-term memory. , 1986, Journal of experimental psychology. General.

[32]  P. Nathan,et al.  Blood alcohol level discrimination. The effects of family history of alcoholism, drinking pattern, and tolerance. , 1980, Archives of general psychiatry.

[33]  M. Schuckit,et al.  MMPI scores in young men with alcoholic relatives and controls. , 1981, The Journal of nervous and mental disease.

[34]  R. Pihl,et al.  An Heuristic Model for the Inherited Predisposition to Alcoholism , 1990 .

[35]  O. Parsons,et al.  Neuropsychological differences between male familial and nonfamilial alcoholics and nonalcoholics. , 1984, Alcoholism, clinical and experimental research.