Hsa_circ_0033155: A potential novel biomarker for non-small cell lung cancer.

Circular RNAs (circRNAs) are a novel type of endogenous RNAs and increasing evidence have uncovered the important role of circRNA in tumor progression; however, the function of circRNAs in non-small cell lung cancer (NSCLC) remains largely unclear. In the present study, it was demonstrated that the expression level of hsa_circ_0033155 was significantly downregulated in NSCLC tissue and the expression of hsa_circ_0033155 correlated with lymphatic metastasis. In order to further investigate the possible role of hsa_circ_0033155 in NSCLC progression, circRNA was overexpressed in NSCLC cells and it was observed that the overexpression of hsa_circ_0033155 significantly decreased cell proliferation, colony formation and migration, and elevated the level of phosphatase and tensin homolog deleted on chromosome 10, a tumor suppressor in many types of tumor. In conclusion, hsa_circ_0033155 may serve as a prospective biomarker for detection and a promising therapeutic target for NSCLC.

[1]  Si-Yu Xia,et al.  CircView: a visualization and exploration tool for circular RNAs , 2019, Briefings in Bioinformatics.

[2]  Yanhong Zhang,et al.  Genetic Ablation of Rbm38 Promotes Lymphomagenesis in the Context of Mutant p53 by Downregulating PTEN. , 2018, Cancer research.

[3]  Haimin Li,et al.  The emerging functions and roles of circular RNAs in cancer. , 2018, Cancer letters.

[4]  Jie Han,et al.  Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression , 2018, Molecular Cancer.

[5]  J. Hung,et al.  Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[6]  J. Kjems,et al.  Circular RNAs in cancer: opportunities and challenges in the field , 2017, Oncogene.

[7]  A. Jemal,et al.  Cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[8]  Ming Xu,et al.  CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients , 2017, Cellular Physiology and Biochemistry.

[9]  Joo Hoon Kim,et al.  PTEN loss and level of HER2 amplification is associated with trastuzumab resistance and prognosis in HER2-positive gastric cancer , 2017, Oncotarget.

[10]  Qian Zhang,et al.  Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[11]  Qian Wang,et al.  Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer. , 2017, Biochemical and biophysical research communications.

[12]  Q. Kan,et al.  Regulation of microRNAs function by circular RNAs in human cancer , 2017, Oncotarget.

[13]  Yi-Neng Han,et al.  A novel type of biomarker and genetic tools in cancer , 2017 .

[14]  Hecheng Zhou,et al.  CircRNA: functions and properties of a novel potential biomarker for cancer , 2017, Molecular Cancer.

[15]  Jun Shen,et al.  Circular RNA participates in the carcinogenesis and the malignant behavior of cancer , 2017, RNA biology.

[16]  Shuhong Zhao,et al.  Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value. , 2017, Pathology, research and practice.

[17]  Shenmin Zhang,et al.  circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family , 2017, Oncogene.

[18]  B. Xiao,et al.  Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. , 2017, Clinica chimica acta; international journal of clinical chemistry.

[19]  J. Beermann,et al.  Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. , 2016, Physiological reviews.

[20]  Ling-Ling Chen.  The biogenesis and emerging roles of circular RNAs , 2016, Nature Reviews Molecular Cell Biology.

[21]  David Gilligan,et al.  Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer. , 2015, The Lancet. Oncology.

[22]  Xiaoyan Mo,et al.  Using circular RNA as a novel type of biomarker in the screening of gastric cancer. , 2015, Clinica chimica acta; international journal of clinical chemistry.

[23]  Kwok-Kin Wong,et al.  Non-small-cell lung cancers: a heterogeneous set of diseases , 2014, Nature Reviews Cancer.

[24]  S. Subramonia-Iyer.  Method of biopsy and sample quality for genetic mutation testing in advanced non-small cell lung cancer in a community hospital. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[25]  P. Pandolfi,et al.  The functions and regulation of the PTEN tumour suppressor , 2012, Nature Reviews Molecular Cell Biology.

[26]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.