Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism
暂无分享,去创建一个
M. Omary | D. Toivola | Lina E Fortelius | J. Nyström | Julia O Misiorek | S. Azhar | J. Liao | A. Habtezion | Haiyan Zhang | M. Asghar | T. Helenius | Julia O. Misiorek | Aida Habtezion | M. Nadeem Asghar | M. Omary
[1] M. Omary,et al. Keratin 8 modulates &bgr;-cell stress responses and normoglycaemia , 2013, Journal of Cell Science.
[2] S. Bultman. Molecular Pathways: Gene–Environment Interactions Regulating Dietary Fiber Induction of Proliferation and Apoptosis via Butyrate for Cancer Prevention , 2013, Clinical Cancer Research.
[3] P. Coulombe,et al. The expanding significance of keratin intermediate filaments in normal and diseased epithelia. , 2013, Current opinion in cell biology.
[4] A. Natarajan,et al. A novel nutrient sensing mechanism underlies substrate-induced regulation of monocarboxylate transporter-1. , 2012, American journal of physiology. Gastrointestinal and liver physiology.
[5] F. Kraemer,et al. Ablation of vimentin results in defective steroidogenesis. , 2012, Endocrinology.
[6] B. Corfe,et al. A proteomic analysis of differential cellular responses to the short-chain fatty acids butyrate, valerate and propionate in colon epithelial cancer cells. , 2012, Molecular bioSystems.
[7] Wei Sun,et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. , 2011, Cell metabolism.
[8] M. Omary,et al. Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon , 2011, Proceedings of the National Academy of Sciences.
[9] Steven R. Brown,et al. Keratin 8 expression in colon cancer associates with low faecal butyrate levels , 2011, BMC gastroenterology.
[10] Y. Naito,et al. Identification of inflammation‐related proteins in a murine colitis model by 2D fluorescence difference gel electrophoresis and mass spectrometry , 2010, Journal of gastroenterology and hepatology.
[11] M. Omary,et al. Intermediate filaments take the heat as stress proteins. , 2010, Trends in cell biology.
[12] Yuquan Wei,et al. Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis , 2009, Journal of Cell Science.
[13] R. Windoffer,et al. Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor , 2009, The Journal of cell biology.
[14] M. Omary,et al. Toward unraveling the complexity of simple epithelial keratins in human disease. , 2009, The Journal of clinical investigation.
[15] K. Eder,et al. Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. , 2008, Biochimica et biophysica acta.
[16] C. Cunningham,et al. Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase. , 2007, Free radical biology & medicine.
[17] D. Jonkers,et al. Review article: the role of butyrate on colonic function , 2007, Alimentary pharmacology & therapeutics.
[18] Stefan Wirtz,et al. Chemically induced mouse models of intestinal inflammation , 2007, Nature Protocols.
[19] D. Haro,et al. Ketogenic HMGCS2 Is a c-Myc Target Gene Expressed in Differentiated Cells of Human Colonic Epithelium and Down-Regulated in Colon Cancer , 2006, Molecular Cancer Research.
[20] E. Birgitte Lane,et al. New consensus nomenclature for mammalian keratins , 2006, The Journal of cell biology.
[21] Philippe Lefebvre,et al. Sorting out the roles of PPARα in energy metabolism and vascular homeostasis , 2006 .
[22] R. Aledo,et al. Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency , 2006, Journal of Inherited Metabolic Disease.
[23] M. Omary,et al. Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment , 2005, Journal of Cell Science.
[24] K. Rapti,et al. Alterations in the heart mitochondrial proteome in a desmin null heart failure model. , 2005, Journal of molecular and cellular cardiology.
[25] Satish K. Singh,et al. Keratins modulate colonocyte electrolyte transport via protein mistargeting , 2004, The Journal of cell biology.
[26] T. Cullingford. The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders. , 2004, Prostaglandins, leukotrienes, and essential fatty acids.
[27] G. Powis,et al. The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice , 2003, Molecular and Cellular Biology.
[28] H. Flint,et al. The microbiology of butyrate formation in the human colon. , 2002, FEMS microbiology letters.
[29] S. Shirazi-Beechey,et al. Substrate‐induced regulation of the human colonic monocarboxylate transporter, MCT1 , 2002, The Journal of physiology.
[30] M. Omary,et al. 'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. , 2002, Current opinion in cell biology.
[31] P. Clifton,et al. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. , 2001, Physiological reviews.
[32] N. Ameen,et al. Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia. , 2001, Journal of cell science.
[33] T. Layden,et al. Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. , 2000, American journal of physiology. Gastrointestinal and liver physiology.
[34] G. Velasco,et al. Do Cytoskeletal Components Control Fatty Acid Translocation into Liver Mitochondria? , 2000, Trends in Endocrinology & Metabolism.
[35] W. Wahli,et al. Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting , 1999 .
[36] F. Hegardt. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. , 1999, The Biochemical journal.
[37] J. Cechetto,et al. A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARα , 1998, The EMBO journal.
[38] N. Perreault,et al. Primary cultures of fully differentiated and pure human intestinal epithelial cells. , 1998, Experimental cell research.
[39] G. Velasco,et al. Malonyl-CoA-independent Acute Control of Hepatic Carnitine Palmitoyltransferase I Activity , 1998, The Journal of Biological Chemistry.
[40] J. McGarry,et al. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. , 1997, European journal of biochemistry.
[41] F. Hegardt,et al. The expression of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A synthase in neonatal rat intestine and liver is under transcriptional control. , 1996, European journal of biochemistry.
[42] F. Hegardt,et al. Tissue-specific Expression and Dietary Regulation of Chimeric Mitochondrial 3-Hydroxy-3-methylglutaryl Coenzyme A Synthase/Human Growth Hormone Gene in Transgenic Mice (*) , 1996, The Journal of Biological Chemistry.
[43] R. Iozzo,et al. Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. , 1994, Genes & development.
[44] G. Gil-Gómez,et al. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. , 1994, The Journal of biological chemistry.
[45] W. Roediger. The starved colon—Diminished mucosal nutrition, diminished absorption, and colitis , 1990, Diseases of the colon and rectum.
[46] M. Ardawi,et al. Glutamine and ketone-body metabolism in the small intestine of starved peak-lactating rats. , 1988, Biochimie.
[47] W. Franke,et al. Heterotypic tetramer (A2D2) complexes of non-epidermal keratins isolated from cytoskeletons of rat hepatocytes and hepatoma cells. , 1984, Journal of molecular biology.
[48] C. Folmes,et al. Myocardial fatty acid metabolism in health and disease. , 2010, Physiological reviews.
[49] B. Corfe,et al. Application of high-content analysis to the study of post-translational modifications of the cytoskeleton. , 2009, Journal of proteome research.
[50] B. Staels,et al. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. , 2006, The Journal of clinical investigation.
[51] W. E. W. ROEDlGER. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man , 2006 .
[52] C. Chaumontet,et al. Expression of mitochondrial HMGCoA synthase and glutaminase in the colonic mucosa is modulated by bacterial species. , 2004, European journal of biochemistry.
[53] M. Omary,et al. Studying simple epithelial keratins in cells and tissues. , 2004, Methods in cell biology.
[54] W. Wahli,et al. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. , 1999, The Journal of clinical investigation.