Temporal changes in bacterial resistance in German intensive care units, 2001-2003: data from the SARI (surveillance of antimicrobial use and antimicrobial resistance in intensive care units) project.

Conservative testing revealed a stable antibiotic resistance situation for Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterobacter cloacae in 32 German intensive care units (ICUs) actively participating in the SARI (surveillance of antimicrobial use and antimicrobial resistance in ICUs) project over a three-year period (2001--2003). No significant changes were shown for methicillin-resistant S. aureus (MRSA) (P=0.501; the MRSA rate increased in 18 ICUs and decreased in 14 ICUs). The only exception was an increase in ciprofloxacin-resistant E. coli.

[1]  R. Gaynes,et al.  Temporal Changes in Prevalence of Antimicrobial Resistance in 23 U.S. Hospitals , 2002, Emerging infectious diseases.

[2]  B. Malorny,et al.  Phenotypic and genotypic characterization of antimicrobial resistance in German Escherichia coli isolates from cattle, swine and poultry. , 2003, The Journal of antimicrobial chemotherapy.

[3]  J. Quinn,et al.  Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use. , 2003, JAMA.

[4]  R. Gaynes,et al.  Monitoring Antimicrobial Use and Resistance: Comparison with a National Benchmark on Reducing Vancomycin Use and Vancomycin-Resistant Enterococci , 2002, Emerging infectious diseases.

[5]  P. Gastmeier,et al.  Design of a Surveillance System of Antibiotic Use and Bacterial Resistance in German Intensive Care Units (SARI) , 2003, Infection.

[6]  R. Wenzel,et al.  Annals of Clinical Microbiology and Antimicrobials Open Access Emerging Resistance among Bacterial Pathogens in the Intensive Care Unit – a European and North American Surveillance Study (2000–2002) Intensive-care Unitantibiotic Susceptibility , 2022 .

[7]  M. Niederman.  Impact of antibiotic resistance on clinical outcomes and the cost of care , 2001, Critical care medicine.

[8]  H. Rüden,et al.  [Surveillance of nosocomial infections in intensive care units. Current data and interpretations]. , 2003, Wiener klinische Wochenschrift.

[9]  J. Karlowsky,et al.  Tracking the implementation of NCCLS M100-S12 expanded-spectrum cephalosporin MIC breakpoints for nonmeningeal isolates of Streptococcus pneumoniae by clinical laboratories in the United States during 2002 and 2003 , 2004, Annals of Clinical Microbiology and Antimicrobials.

[10]  Marcia M Ward,et al.  Antimicrobial resistance trends and outbreak frequency in United States hospitals. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[11]  P. Gastmeier,et al.  Stenotrophomonas maltophilia and antibiotic use in German intensive care units: data from Project SARI (Surveillance of Antimicrobial Use and Antimicrobial Resistance in German Intensive Care Units). , 2006, The Journal of hospital infection.

[12]  Nnis System.  National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2003, issued August 2003. , 2003, American journal of infection control.