Sensitive and Reproducible Gold SERS Sensor Based on Interference Lithography and Electrophoretic Deposition

Surface-enhanced Raman spectroscopy (SERS) is a promising analytical tool due to its label-free detection ability and superior sensitivity, which enable the detection of single molecules. Since its sensitivity is highly dependent on localized surface plasmon resonance, various methods have been applied for electric field-enhanced metal nanostructures. Despite the intensive research on practical applications of SERS, fabricating a sensitive and reproducible SERS sensor using a simple and low-cost process remains a challenge. Here, we report a simple strategy to produce a large-scale gold nanoparticle array based on laser interference lithography and the electrophoretic deposition of gold nanoparticles, generated through a pulsed laser ablation in liquid process. The fabricated gold nanoparticle array produced a sensitive, reproducible SERS signal, which allowed Rhodamine 6G to be detected at a concentration as low as 10−8 M, with an enhancement factor of 1.25 × 105. This advantageous fabrication strategy is expected to enable practical SERS applications.

[1]  Harald Giessen,et al.  Large-area two-dimensional photonic crystals of metallic nanocylinders based on colloidal gold nanoparticles , 2007 .

[2]  Sivashankar Krishnamoorthy,et al.  Nanoparticle cluster arrays for high-performance SERS through directed self-assembly on flat substrates and on optical fibers. , 2012, ACS nano.

[3]  W. Cai,et al.  Au nanoparticle-built mesoporous films based on co-electrophoresis deposition and selective etching , 2014 .

[4]  Michael J Sepaniak,et al.  Controllable nanofabrication of aggregate-like nanoparticle substrates and evaluation for surface-enhanced Raman spectroscopy. , 2009, ACS nano.

[5]  J. Liao,et al.  Target-size embracing dimension for sensitive detection of viruses with various sizes and influenza virus strains. , 2012, Biosensors & bioelectronics.

[6]  Emmanuel Rinnert,et al.  Surface enhanced Raman scattering optimization of gold nanocylinder arrays: Influence of the localized surface plasmon resonance and excitation wavelength , 2010 .

[7]  Tuan Vo-Dinh,et al.  Gold Nanostars For Surface-Enhanced Raman Scattering: Synthesis, Characterization and Optimization. , 2008, The journal of physical chemistry. C, Nanomaterials and interfaces.

[8]  Dong Qin,et al.  Inverted size-dependence of surface-enhanced Raman scattering on gold nanohole and nanodisk arrays. , 2008, Nano letters.

[9]  N. G. Semaltianos,et al.  Electrophoretic deposition on graphene of Au nanoparticles generated by laser ablation of a bulk Au target in water , 2015 .

[10]  P. Sarkar,et al.  Electrophoretic Deposition (EPD): Mechanisms, Kinetics, and Application to Ceramics , 1996 .

[11]  M. Meneghetti,et al.  Laser ablation synthesis in solution and size manipulation of noble metal nanoparticles. , 2009, Physical chemistry chemical physics : PCCP.

[12]  Zhihong Wang,et al.  Electron-beam lithography of gold nanostructures for surface-enhanced Raman scattering , 2012 .

[13]  B. Ren,et al.  Size Effect on SERS of Gold Nanorods Demonstrated via Single Nanoparticle Spectroscopy , 2016 .

[14]  Paul V. Braun,et al.  Fabrication of Three‐Dimensional Photonic Crystals Using Multibeam Interference Lithography and Electrodeposition , 2009 .

[15]  S. Barcikowski,et al.  Laser-synthesized ligand-free Au nanoparticles for contrast agent applications in computed tomography and magnetic resonance imaging. , 2016, Journal of materials chemistry. B.

[16]  Laxmidhar Besra,et al.  A review on fundamentals and applications of electrophoretic deposition (EPD) , 2007 .

[17]  Jean-Michel Lourtioz,et al.  Soft UV nanoimprint lithography-designed highly sensitive substrates for SERS detection , 2014, Nanoscale Research Letters.

[18]  Honghua Zhang,et al.  Rapid Synthesis of Monodisperse Au Nanospheres through a Laser Irradiation -Induced Shape Conversion, Self-Assembly and Their Electromagnetic Coupling SERS Enhancement , 2015, Scientific Reports.

[19]  W. Leung,et al.  Fabrication of metallic nanowires and nanoribbons using laser interference lithography and shadow lithography , 2010, Nanotechnology.

[20]  Jakub Dostalek,et al.  Tunable laser interference lithography preparation of plasmonic nanoparticle arrays tailored for SERS. , 2018, Nanoscale.

[21]  J. Liao,et al.  Focused ion beam-fabricated Au micro/nanostructures used as a surface enhanced Raman scattering-active substrate for trace detection of molecules and influenza virus , 2011, Nanotechnology.

[22]  Bo Liu,et al.  Large-scale uniform Au nanodisk arrays fabricated via x-ray interference lithography for reproducible and sensitive SERS substrate , 2014, Nanotechnology.

[23]  V. Liberman,et al.  A Nanoparticle Convective Directed Assembly Process for the Fabrication of Periodic Surface Enhanced Raman Spectroscopy Substrates , 2010, Advanced materials.

[24]  Shikuan Yang,et al.  From Nanoparticles to Nanoplates: Preferential Oriented Connection of Ag Colloids during Electrophoretic Deposition , 2009 .

[25]  Yong Lei,et al.  Surface Nanometer‐Scale Patterning in Realizing Large‐Scale Ordered Arrays of Metallic Nanoshells with Well‐Defined Structures and Controllable Properties , 2010 .

[26]  N. Lu,et al.  Droplet-Confined Electroless Deposition of Silver Nanoparticles on Ordered Superhydrophobic Structures for High Uniform SERS Measurements. , 2017, ACS applied materials & interfaces.

[27]  J. Lunney,et al.  Surface-enhanced Raman spectroscopy (SERS) using Ag nanoparticle films produced by pulsed laser deposition , 2013 .

[28]  M. Fleischmann,et al.  Raman spectra of pyridine adsorbed at a silver electrode , 1974 .

[29]  S. Barcikowski,et al.  Laser Synthesis and Processing of Colloids: Fundamentals and Applications. , 2017, Chemical reviews.

[30]  D. Chrisey,et al.  Pulsed laser ablation in liquid for micro-/nanostructure generation , 2012 .

[31]  Shikuan Yang,et al.  Ultrasensitive surface-enhanced Raman scattering detection in common fluids , 2015, Proceedings of the National Academy of Sciences.

[32]  W. Cai,et al.  Au nanochain-built 3D netlike porous films based on laser ablation in water and electrophoretic deposition. , 2010, Chemical communications.

[33]  Lili He,et al.  Hydrophobic ligand-mediated hierarchical Cu nanoparticles on reduced graphene oxides for SERS platform , 2016 .

[34]  Yasin Ekinci,et al.  Sub-10 nm patterning using EUV interference lithography , 2011, Nanotechnology.

[35]  C. Kavitha,et al.  Low cost, ultra-thin films of reduced graphene oxide–Ag nanoparticle hybrids as SERS based excellent dye sensors , 2015 .

[36]  Sunghoon Kwon,et al.  Highly uniform and reproducible surface-enhanced Raman scattering from DNA-tailorable nanoparticles with 1-nm interior gap. , 2011, Nature nanotechnology.

[37]  Min-Min Xu,et al.  Improving the SERS detection sensitivity of aromatic molecules by a PDMS-coated Au nanoparticle monolayer film , 2015 .

[38]  S. Lieberman,et al.  Detection of volatile organic compounds using surface enhanced Raman spectroscopy substrates mounted on a thermoelectric cooler , 2003 .

[39]  Ernestina Castro-Longoria,et al.  SERS Properties of Different Sized and Shaped Gold Nanoparticles Biosynthesized under Different Environmental Conditions by Neurospora crassa Extract , 2013, PLoS ONE.

[40]  K. Kneipp,et al.  SERS--a single-molecule and nanoscale tool for bioanalytics. , 2008, Chemical Society reviews.

[41]  B. Reinhard,et al.  Engineering Nanoparticle Cluster Arrays for Bacterial Biosensing: The Role of the Building Block in Multiscale SERS Substrates , 2010 .

[42]  Jing Zheng,et al.  Detection of Circulating Tumor DNA in Human Blood via DNA-Mediated Surface-Enhanced Raman Spectroscopy of Single-Walled Carbon Nanotubes. , 2016, Analytical chemistry.