Rayleigh-scattering microscopy for tracking and sizing nanoparticles in focused aerosol beams

Rayleigh-scattering microscopy permits tracking and sizing of aerosolized particles down to 40 nm in diameter. It lays the foundation for lab-based injector development and online injection diagnostics for X-ray free-electron laser (XFEL) research.

[1]  Anton Barty,et al.  Imaging single cells in a beam of live cyanobacteria with an X-ray laser , 2015, Nature Communications.

[2]  J. Feldhaus,et al.  FLASH—the first soft x-ray free electron laser (FEL) user facility , 2010 .

[3]  Garth J. Williams,et al.  Single mimivirus particles intercepted and imaged with an X-ray laser , 2011, Nature.

[4]  E. Kerstel,et al.  Campargue-type supersonic beam sources: Absolute intensities, skimmer transmission and scaling laws for mono-atomic gases He, Ne and Ar , 1985 .

[5]  Kenneth A. Smith,et al.  Characterization of an aerodynamic lens for transmitting particles greater than 1 micrometer in diameter into the Aerodyne aerosol mass spectrometer , 2013 .

[6]  Garth J. Williams,et al.  Liquid explosions induced by X-ray laser pulses , 2015, Nature Physics.

[7]  Z. Kam,et al.  Absorption and Scattering of Light by Small Particles , 1998 .

[8]  Anton Barty,et al.  High-throughput imaging of heterogeneous cell organelles with an X-ray laser , 2014, Nature Photonics.

[9]  Takashi Kimura,et al.  Imaging live cell in micro-liquid enclosure by X-ray laser diffraction , 2014, Nature Communications.

[10]  H. Chapman,et al.  Explosion dynamics of sucrose nanospheres monitored by time of flight spectrometry and coherent diffractive imaging at the split-and-delay beam line of the FLASH soft X-ray laser. , 2014, Optics express.

[11]  Jean-Michel Claverie,et al.  Three-dimensional reconstruction of the giant mimivirus particle with an x-ray free-electron laser. , 2015, Physical review letters.

[12]  E Banas,et al.  Search for Higgs and Z boson decays to J/ψγ and ϒ(nS)γ with the ATLAS detector , 2015, 1501.03276.

[13]  Anton Barty,et al.  Coherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source , 2017, Scientific Data.

[14]  H. Chapman,et al.  Visualizing aerosol-particle injection for diffractive-imaging experiments. , 2015, Optics express.

[15]  Y. Cheng,et al.  Properties of continuum source particle beams. I. Calculation methods and results , 1979 .

[16]  G. W. Sears,et al.  Production of Particulate Beams , 1964 .

[17]  C. Voigt,et al.  Focusing of Aerosols into a Particle Beam at Pressures from 10 to 150 Torr , 1999 .

[18]  Sébastien Boutet,et al.  The Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS) , 2010 .

[19]  K. Schmidt,et al.  Gas dynamic virtual nozzle for generation of microscopic droplet streams , 2008, 0803.4181.

[20]  H. Chapman,et al.  Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers , 2015, Structural dynamics.

[21]  S. Marchesini,et al.  Femtosecond diffractive imaging of biological cells , 2010 .

[22]  Georg Weidenspointner,et al.  Femtosecond free-electron laser x-ray diffraction data sets for algorithm development. , 2011, Optics express.

[23]  Anton Barty,et al.  Femtosecond X-ray diffraction from an aerosolized beam of protein nanocrystals , 2017, Journal of applied crystallography.

[24]  Anton Barty,et al.  Experimental strategies for imaging bioparticles with femtosecond hard X-ray pulses , 2017, IUCrJ.

[25]  Li Fang,et al.  Ultra-fast and ultra-intense x-ray sciences: first results from the Linac Coherent Light Source free-electron laser , 2013 .

[26]  C. B. Henderson,et al.  Drag Coefficients of Spheres in Continuum and Rarefied Flows , 1976 .

[27]  David B. Kittelson,et al.  Generating Particle Beams of Controlled Dimensions and Divergence: I. Theory of Particle Motion in Aerodynamic Lenses and Nozzle Expansions , 1995 .

[28]  H. Chapman,et al.  Incoherent Diffractive Imaging via Intensity Correlations of Hard X Rays. , 2017, Physical Review Letters.

[29]  J. Hajdu,et al.  Potential for biomolecular imaging with femtosecond X-ray pulses , 2000, Nature.

[30]  Peter H. McMurry,et al.  A Design Tool for Aerodynamic Lens Systems , 2006 .

[31]  W. H. Benner,et al.  Single particle X-ray diffractive imaging. , 2007, Nano letters.

[32]  R. Zandi,et al.  Contact Mechanics of a Small Icosahedral Virus. , 2017, Physical review letters.

[33]  R. Campargue.  Progress in overexpanded supersonic jets and skimmed molecular beams in free-jet zones of silence , 1984 .

[34]  Peng Liu,et al.  Generating Particle Beams of Controlled Dimensions and Divergence: II. Experimental Evaluation of Particle Motion in Aerodynamic Lenses and Nozzle Expansions , 1995 .

[35]  Alfonso M. Gañán-Calvo,et al.  Generation of Steady Liquid Microthreads and Micron-Sized Monodisperse Sprays in Gas Streams , 1998 .