Online monitoring of urea concentration in dialysate with dual-beam Fourier-transform near-infrared spectroscopy.

The robustness of a dual-beam, optical null, Fourier-transform near-infrared (FTNIR) spectrometer was investigated by means of online, near-infrared measurements and predictions of urea concentrations in spent dialysate during hemodialysis treatment. Simple multivariate calibration using a few factors based on a small number of prepared samples provided stable and accurate predictions over a period of 1 month. The calibration was robust when faced with adjustment of reference cell intensity and did not require a daily measured reference spectrum. The root-mean-square error of prediction of urea was 0.4 mM based on a two-factor partial least-squares regression model.

[1]  J. Bak,et al.  Measurements of Urea and Glucose in Aqueous Solutions with Dual-Beam Near-Infrared Fourier Transform Spectroscopy , 2002 .

[2]  F. A. Seiler,et al.  Numerical Recipes in C: The Art of Scientific Computing , 1989 .

[3]  Kevin H. Hazen,et al.  Temperature-Insensitive Near-Infrared Spectroscopic Measurement of Glucose in Aqueous Solutions , 1994 .

[4]  Mark A. Arnold,et al.  Online measurement of urea concentration in spent dialysate during hemodialysis , 2002, SPIE BiOS.

[5]  Kevin H. Hazen,et al.  Measurement of Glucose in Water with First-Overtone Near-Infrared Spectra , 1998 .

[6]  Stefan Andersson-Engels,et al.  Determination of urea, glucose, and phosphate in dialysate with Fourier transform infrared spectroscopy. , 2004, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[7]  A. Parnham,et al.  Urea kinetic modelling: a measure of dialysis adequacy , 2001, Annals of clinical biochemistry.

[8]  William H. Press,et al.  The Art of Scientific Computing Second Edition , 1998 .

[9]  H. R. Chandrasekhar,et al.  Double-beam fourier spectroscopy with two inputs and two outputs , 1976 .

[10]  M. Arnold,et al.  Near-infrared spectroscopy for measuring urea in hemodialysis fluids. , 2001, Clinical chemistry.

[11]  O. Khalil,et al.  Spectroscopic and clinical aspects of noninvasive glucose measurements. , 1999, Clinical chemistry.

[12]  M. Arnold,et al.  Online measurement of urea concentration in spent dialysate during hemodialysis. , 2004, Clinical chemistry.

[13]  M. Hutson,et al.  Direct Phase Correction of Differential FT-IR Spectra , 1998 .