Respiratory cytology: A review of non‐neoplastic mimics of malignancy

Respiratory cytology has its share of pitfalls. Some, such as vegetable cell contaminants, pose problems for only inexperienced observers, while others, such as reactive bronchoalveolar cells from pneumonia, can lead even experienced cytopathologists to make a misdiagnosis of malignancy. This review illustrates and analyzes those benign conditions or entities known to mimic malignancy in exfoliative respiratory cytology and fine‐needle aspiration biopsy of the lung. Entities are grouped by the type of malignancy they mimic, and guidelines are presented for avoiding specific pitfalls.

[1]  Berman Jj,et al.  Widespread posttracheostomy atypia simulating squamous cell carcinoma. A case report. , 1991 .

[2]  P. Swanson,et al.  Reactive type II pneumocytes in bronchoalveolar lavage fluid from adult respiratory distress syndrome can be mistaken for cells of adenocarcinoma , 1990, Diagnostic cytopathology.

[3]  M. Sagawa,et al.  Cytologic study of tissue repair in human bronchial epithelium. , 1988, Acta cytologica.

[4]  D. Rosenthal.  Cytopathology of pulmonary disease. , 1988, Monographs in clinical cytology.

[5]  S. Robboy,et al.  Pulmonary cytology of the acquired immune deficiency syndrome: An analysis of 36 cases , 1986, Diagnostic cytopathology.

[6]  S. Selvaggi,et al.  Pulmonary cytology in patients with the acquired immunodeficiency syndrome (AIDS) , 1986, Diagnostic cytopathology.

[7]  J. Frost.  XII. Atypical Functional Differentiation: Keratinized Stratified Squamous Epithelium and Squamous Cell Carcinoma , 1986 .

[8]  J. Frost.  VIII. Morphologic Characteristics of Proplasia: Increased General Activity , 1986 .

[9]  J. Silverman,et al.  Fine needle aspiration cytology of pulmonary infarct. , 1985, Acta cytologica.

[10]  J C Eggleston,et al.  Transthoracic needle aspiration biopsy of benign and malignant lung lesions. , 1985, AJR. American journal of roentgenology.

[11]  C. Bedrossian,et al.  Cytopathology of Nonneoplastic Pulmonary Disease , 1983 .

[12]  B. Naylor,et al.  Vegetable cell contaminants in cytologic specimens: their resemblance to cells associated with various normal and pathologic states. , 1981, Acta cytologica.

[13]  W. Sinner,et al.  Pulmonary neoplasms diagnosed with transthoracic needle biopsy , 1979, Cancer.

[14]  W. Frable,et al.  Diagnostic respiratory cytopathology , 1979 .

[15]  C. Flower,et al.  Percutaneous needle biopsy of thoracic lesions--an evaluation of 300 biopsies. , 1979, Clinical radiology.

[16]  Bedrossian Cw,et al.  Abnormal sputum cytopathology during chemotherapy with bleomycin. , 1978 .

[17]  L. Mccormack,et al.  Aspiration biopsies of chest lesions. , 1978, Radiology.

[18]  W. Frable,et al.  False-positive cytological diagnosis of lung carcinoma in patients with pulmonary infarcts. , 1977, The Annals of thoracic surgery.

[19]  H. Grunze.  Cytologic diagnosis of tumors of the chest. , 1973, Acta cytologica.

[20]  L. Koss.  Diagnostic cytology and its histopathologic bases , 1968 .

[21]  D. Louria,et al.  Pulmonary mycetoma due to Allescheria boydii. , 1966, Archives of internal medicine.

[22]  M. Melamed,et al.  Tracheo-bronchial cytology after laryngectomy for carcinoma of larynx. II. Benign atypias. , 1966, Acta cytologica.

[23]  Kern Wh.  Cytology of hyperplastic and neoplastic lesions of terminal bronchioles and alveoli. , 1965 .

[24]  B. Naylor,et al.  A pitfall in the cytodiagnosis of sputum of asthmatics , 1964, Journal of clinical pathology.

[25]  D. Kinsella.  Bronchial cell atypias: A report of a preliminary study correlating cytology with histology , 1959, Cancer.

[26]  L. Koss,et al.  some pitfalls of cytological diagnosis of lung cancer , 1955, Cancer.