Prophylactic administration of ephedrine against hypotensive effect of anaesthesic induction without myorelaxant: A-518

Department of Anesthesiology and Intensive Care, Purpan Hospital, Toulouse, France Background and Goals: The aim of this study was to determine the effectiveness of two prophylactic administrations of ephedrine against hypotensive effect of anaesthesic induction without myorelaxant. Material and Methods: 60 patients were randomly allocated to one of the 3 groups (n 20): normal saline bolus and infusion (Control), ephedrine 0.2 mg/kg bolus and normal saline infusion (Bolus group) or ephedrine 0.1 mg/kg bolus followed with 0.1 mg kg 1 h 1 of ephedrine (Infusion group). Anaesthesia was induced with propofol (3 mg/kg) and remifentanil (1 mcg/kg followed with 0.5 mcg kg 1 min 1 until intubation, then 0.2 mcg kg 1 min 1). Mean arterial pressure (MAP) and Heart rate (HR) were measured before and every minute after induction (T0) during 20 minutes. In all groups additional bolus of ephedrine could be administrated in case of hypotension (MAP 60 mmHg). Results: Evolution of MAP was different in the three groups (Figure). HR was initially significantly higher and patients received more additional bolus of ephedrine in the Bolus group as compared to the Infusion group.