Phenotypic In Vivo Screening to Identify New, Unpredicted Indications for Existing Drugs and Drug Candidates
暂无分享,去创建一个
Christopher A. Lipinski | C. Lipinski | A. Reaume | Michael S. Saporito | Andrew Reaume | M. Saporito
[1] J. Vane,et al. Anti-inflammatory drugs and their mechanism of action , 1998, Inflammation Research.
[2] N. Inagaki,et al. Inhibition of scratching behavior associated with allergic dermatitis in mice by tacrolimus, but not by dexamethasone. , 2006, European journal of pharmacology.
[3] R. DuBois,et al. COX-2 inhibition and colorectal cancer. , 2004, Seminars in oncology.
[4] C. Teter,et al. Treatment of Affective Disorder and Obesity with Topiramate , 2000, The Annals of pharmacotherapy.
[5] J. Buccafusco,et al. The preclinical pharmacological profile of WAY-132983, a potent M1 preferring agonist. , 2000, The Journal of pharmacology and experimental therapeutics.
[6] Norman Wolmark,et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. , 2006, JAMA.
[7] K. Gadde,et al. Bupropion SR enhances weight loss: a 48-week double-blind, placebo- controlled trial. , 2002, Obesity research.
[8] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. , 2001, Advanced drug delivery reviews.
[9] Sean Ekins,et al. In silico repositioning of approved drugs for rare and neglected diseases. , 2011, Drug discovery today.
[10] J. Cryan,et al. The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice , 2005, Neuroscience & Biobehavioral Reviews.
[11] F. Sinicrope. Targeting cyclooxygenase‐2 for prevention and therapy of colorectal cancer , 2006, Molecular carcinogenesis.
[12] J. Buccafusco,et al. The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant-conditioning memory tasks for screening drug candidates , 2008, Psychopharmacology.
[13] S. Zamvil,et al. Statins and demyelination. , 2008, Current topics in microbiology and immunology.
[14] J. Bryans,et al. 3‐Substituted GABA analogs with central nervous system activity: A review , 1999, Medicinal research reviews.
[15] Louis A Tartaglia. Complementary new approaches enable repositioning of failed drug candidates , 2006, Expert opinion on investigational drugs.
[16] P. E. Gold,et al. Attenuation of scopolamine-induced amnesia in mice , 1988, Psychopharmacology.
[17] G. Keating,et al. Raloxifene , 2012, Drugs.
[18] R. Peterson,et al. Systematizing Serendipity for Cardiovascular Drug Discovery , 2009, Circulation.
[19] Jennie Z Ma,et al. Oral topiramate for treatment of alcohol dependence: a randomised controlled trial , 2003, The Lancet.
[20] D. Swinney,et al. How were new medicines discovered? , 2011, Nature Reviews Drug Discovery.
[21] D. Baker,et al. Inflammation in neurodegenerative diseases , 2010, Immunology.
[22] G. Woodruff,et al. The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed byd-serine , 1996, Psychopharmacology.
[23] L. Vallée,et al. Topiramate: efficacy and tolerability in children according to epilepsy syndromes , 2003, Epilepsy Research.
[24] J. Corbin,et al. PHARMACOLOGY OF PHOSPHODIESTERASE‐5 INHIBITORS , 2002, International journal of clinical practice.
[25] B. Druker,et al. Specific Targeted Therapy of Chronic Myelogenous Leukemia with Imatinib , 2003, Pharmacological Reviews.
[26] M A Geyer,et al. Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. , 1998, Schizophrenia bulletin.
[27] J. Simard,et al. Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity. , 1995, The Journal of investigative dermatology.
[28] T. Jay,et al. A pathophysiological paradigm for the therapy of psychiatric disease , 2005, Nature Reviews Drug Discovery.
[29] R. Beltran,et al. Pitfalls in health communication: healthcare policy, institution, structure, and process. , 2004, MedGenMed : Medscape general medicine.
[30] T. Sanke,et al. The angiotensin II receptor blocker telmisartan improves insulin resistance and has beneficial effects in hypertensive patients with type 2 diabetes and poor glycemic control. , 2008, Diabetes research and clinical practice.
[31] D. Drucker. Dipeptidyl Peptidase-4 Inhibition and the Treatment of Type 2 Diabetes , 2007, Diabetes Care.
[32] M. Williams,et al. Challenges in the Search for Drugs to Treat Central Nervous System Disorders , 2009, Journal of Pharmacology and Experimental Therapeutics.
[33] J. Bovill. Pharmacology and clinical action of COX-2 selective NSAIDs. , 2003, Advances in experimental medicine and biology.
[34] G. Koch,et al. Beyond the Cholinergic Hypothesis: Do Current Drugs Work in Alzheimer's Disease? , 2010, CNS neuroscience & therapeutics.
[35] D. Flood,et al. Characterization of Pharmacological and Wake-Promoting Properties of the Dopaminergic Stimulant Sydnocarb in Rats , 2011, Journal of Pharmacology and Experimental Therapeutics.
[36] Magda Melchert,et al. The thalidomide saga. , 2007, The international journal of biochemistry & cell biology.
[37] U. Landmesser,et al. Nonlipid-lowering effects of statins , 2005, Current treatment options in cardiovascular medicine.
[38] S. Tonstad,et al. A multicentre, randomized, double‐blind, placebo‐controlled, 1‐year study of bupropion SR for smoking cessation , 2003, Journal of internal medicine.
[39] Marc K Hellerstein,et al. Exploiting Complexity and the Robustness of Network Architecture for Drug Discovery , 2008, Journal of Pharmacology and Experimental Therapeutics.
[40] Y. Chagnon,et al. Genetics of obesity: advances from rodent studies. , 1996, Trends in genetics : TIG.
[41] B. Munos. Lessons from 60 years of pharmaceutical innovation , 2009, Nature Reviews Drug Discovery.
[42] K. Offord,et al. Treatment of asthma with nebulized lidocaine: a randomized, placebo-controlled study. , 2004, The Journal of allergy and clinical immunology.
[43] E. Fauman,et al. Pharmacology and mechanism of action of pregabalin: The calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery , 2007, Epilepsy Research.
[44] J. Corbin,et al. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. , 1999, The American journal of cardiology.
[45] B. Patterson,et al. Topiramate augmentation in treatment‐resistant obsessive–compulsive disorder: a retrospective, open‐label case series , 2006, Depression and anxiety.
[46] F. Rambert,et al. Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals. , 1990, European journal of pharmacology.
[47] T. Brue,et al. Medical Treatment of Cushing’s Syndrome: Glucocorticoid Receptor Antagonists and Mifepristone , 2010, Neuroendocrinology.
[48] M. Birnbaum,et al. An energetic tale of AMPK-independent effects of metformin. , 2010, The Journal of clinical investigation.
[49] J C Gingell,et al. Sildenafil, a novel effective oral therapy for male erectile dysfunction. , 1996, British journal of urology.
[50] E. Tobinick. The value of drug repositioning in the current pharmaceutical market. , 2009, Drug news & perspectives.
[51] F. Sams-Dodd. Target-based drug discovery: is something wrong? , 2005, Drug discovery today.
[52] R. Nagai,et al. Adipose tissue inflammation in obesity and metabolic syndrome. , 2009, Discovery medicine.
[53] Michel Bourin,et al. Forced swimming test in mice: a review of antidepressant activity , 2004, Psychopharmacology.
[54] T. Ashburn,et al. Drug repositioning: identifying and developing new uses for existing drugs , 2004, Nature Reviews Drug Discovery.
[55] S. Bryan,et al. Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. , 2008, Health technology assessment.
[56] Sanjay Joshua Swamidass,et al. Mining small-molecule screens to repurpose drugs , 2011, Briefings Bioinform..
[57] J. Clader. The discovery of ezetimibe: a view from outside the receptor. , 2004, Journal of medicinal chemistry.
[58] M. Karagianni,et al. Favorable response to subcutaneous administration of infliximab in rats with experimental colitis. , 2005, World journal of gastroenterology.
[59] Paul Gerrard,et al. Mechanisms of modafinil: A review of current research , 2007, Neuropsychiatric disease and treatment.
[60] K. Yonkers,et al. Review of fluoxetine and its clinical applications in premenstrual dysphoric disorder , 2002, Expert opinion on pharmacotherapy.
[61] B. Spiegelman,et al. PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth* , 2001, The Journal of Biological Chemistry.
[62] L. Arnold. Duloxetine and other antidepressants in the treatment of patients with fibromyalgia. , 2007, Pain medicine.
[63] P. Vaitkus,et al. Drug-Eluting Stents To Prevent Reblockage of Coronary Arteries , 2003, The Journal of cardiovascular nursing.
[64] R. DuBois,et al. Therapeutic potential of peroxisome proliferator-activated receptors in chronic inflammation and colorectal cancer. , 2010, Gastroenterology clinics of North America.
[65] S. Youssef,et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease , 2002, Nature.
[66] S. Connor,et al. Antidiabetic Efficacy of BRL 49653, a Potent Orally Active Insulin Sensitizing Agent, Assessed in the C57BL/KsJ db/db Diabetic Mouse by Non‐invasive 1H NMR Studies of Urine , 1997, The Journal of pharmacy and pharmacology.
[67] C. Lipinski,et al. The Lyn Kinase Activator MLR-1023 Is a Novel Insulin Receptor Potentiator that Elicits a Rapid-Onset and Durable Improvement in Glucose Homeostasis in Animal Models of Type 2 Diabetes , 2012, Journal of Pharmacology and Experimental Therapeutics.
[68] J. Oakman,et al. An open trial of topiramate in the treatment of generalized social phobia. , 2004, The Journal of clinical psychiatry.
[69] M. Wadenberg. Conditioned avoidance response in the development of new antipsychotics. , 2010, Current pharmaceutical design.
[70] David Brown,et al. Unfinished business: target-based drug discovery. , 2007, Drug discovery today.
[71] T. Rozen. Antiepileptic Drugs in the Management of Cluster Headache and Trigeminal Neuralgia , 2001, Headache.
[72] E. Elinav,et al. CCL2 (pM levels) as a therapeutic agent in inflammatory bowel disease models in mice , 2010, Inflammatory bowel diseases.
[73] N. Thornberry,et al. Discovery of JANUVIA TM (Sitagliptin), a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type2 Diabetes. , 2007 .
[74] Sean Ekins,et al. Finding Promiscuous Old Drugs for New Uses , 2011, Pharmaceutical Research.
[75] S. Lukas,et al. Buprenorphine treatment of refractory depression. , 1995, Journal of clinical psychopharmacology.
[76] Jun O. Liu,et al. A clinical drug library screen identifies astemizole as an antimalarial agent , 2006, Nature chemical biology.
[77] Marc K Hellerstein,et al. A critique of the molecular target-based drug discovery paradigm based on principles of metabolic control: advantages of pathway-based discovery. , 2008, Metabolic engineering.
[78] A. Markham,et al. Sildenafil: a review of its use in erectile dysfunction. , 1999, Drugs.
[79] I. Bruce,et al. Etanercept and infliximab for the treatment of psoriatic arthritis: a systematic review. , 2006, Clinical and experimental rheumatology.
[80] Sidney H Kennedy,et al. Topiramate versus bupropion SR when added to mood stabilizer therapy for the depressive phase of bipolar disorder: a preliminary single-blind study. , 2002, Bipolar disorders.
[81] K. Petersen,et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. , 2000, Diabetes.
[82] B. Hawes,et al. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[83] P. Ward,et al. Molecular and Cellular Basis of Inflammation , 1999, Current Inflammation Research.
[84] M. Siddiqui,et al. Infliximab: a review of its use in Crohn's disease and rheumatoid arthritis. , 2005, Drugs.
[85] H. Meltzer,et al. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems. , 2008, Progress in brain research.
[86] S. Irwin,et al. Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse , 1968, Psychopharmacologia.
[87] Mitchell A. Avery,et al. Identification of Telmisartan as a Unique Angiotensin II: Receptor Antagonist With Selective PPARγ–Modulating Activity , 2004, Hypertension.
[88] N. Chabbert-Buffet,et al. Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications. , 2005, Human reproduction update.
[89] A. Hopkins. Network pharmacology: the next paradigm in drug discovery. , 2008, Nature chemical biology.
[90] C. Serhan. Systems approach to inflammation resolution: identification of novel anti‐inflammatory and pro‐resolving mediators , 2009, Journal of thrombosis and haemostasis : JTH.
[91] K. Fouad,et al. The unilateral 6‐OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis , 2005, The European journal of neuroscience.
[92] G. Elmer,et al. Drug discovery in psychiatric illness: mining for gold. , 2009, Schizophrenia bulletin.
[93] A. Young,et al. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). , 1999, Diabetes.
[94] N. Richard,et al. Bupropion XL in adults with attention-deficit/hyperactivity disorder: A randomized, placebo-controlled study , 2005, Biological Psychiatry.
[95] M. E. Kosman. Evaluation of a new antihypertensive agent. Minoxidil. , 1980, JAMA.
[96] Michael E. Furrow. Pharmaceutical patent life-cycle management after KSR v. Teleflex. , 2008, Food and drug law journal.
[97] J. Rundegren,et al. Minoxidil: mechanisms of action on hair growth , 2004, The British journal of dermatology.
[98] R. Stafford,et al. Off-label prescribing among office-based physicians. , 2006, Archives of internal medicine.
[99] M. Kakei,et al. Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice. , 2005, Endocrine journal.
[100] D. Wong,et al. Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in vitro and in vivo, Human Serotonin Receptor Subtypes, and Other Neuronal Receptors , 2001, Neuropsychopharmacology.
[101] J. Drews. Drug discovery: a historical perspective. , 2000, Science.
[102] T. Heffner,et al. Structure−Activity Relationships of Pregabalin and Analogues That Target the α2-δ Protein , 2005 .
[103] N R Ackerman,et al. Bronchodilator and antiulcer phenoxypyrimidinones. , 1980, Journal of medicinal chemistry.
[104] H. Bischoff. The mechanism of alpha-glucosidase inhibition in the management of diabetes. , 1995, Clinical and investigative medicine. Medecine clinique et experimentale.
[105] The concept of depression as a dysfunction of the immune system. , 2010, Current immunology reviews.
[106] David Jou,et al. Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3). , 2011, Journal of medicinal chemistry.