Skin Keratins.

[1]  J. Taube,et al.  Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes , 2015, Nature Genetics.

[2]  P. Coulombe,et al.  A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes , 2015, The Journal of cell biology.

[3]  Erika Ilagan,et al.  Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes , 2015, The Journal of cell biology.

[4]  P. Boor,et al.  Keratins in health and disease. , 2015, Current opinion in cell biology.

[5]  P. Coulombe,et al.  Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice* , 2014, The Journal of Biological Chemistry.

[6]  M. Omary,et al.  Post-translational modifications of intermediate filament proteins: mechanisms and functions , 2014, Nature Reviews Molecular Cell Biology.

[7]  A. Balmain,et al.  Keratin 16 regulates innate immunity in response to epidermal barrier breach , 2013, Proceedings of the National Academy of Sciences.

[8]  J. Käs,et al.  Keratins significantly contribute to cell stiffness and impact invasive behavior , 2013, Proceedings of the National Academy of Sciences.

[9]  P. Coulombe,et al.  The expanding significance of keratin intermediate filaments in normal and diseased epithelia. , 2013, Current opinion in cell biology.

[10]  Joachim L. Schultze,et al.  Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18 , 2012, Journal of Cell Science.

[11]  James J. Mun,et al.  Cytokeratins mediate epithelial innate defense through their antimicrobial properties. , 2012, The Journal of clinical investigation.

[12]  E. Lane,et al.  Keratins and disease at a glance , 2012, Journal of Cell Science.

[13]  P. Coulombe,et al.  A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair , 2012, The Journal of cell biology.

[14]  M. Beil,et al.  Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia , 2011, The Journal of cell biology.

[15]  C. Moore,et al.  Keratin disorders: from gene to therapy. , 2011, Human molecular genetics.

[16]  P. Coulombe,et al.  Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin , 2010, Nature Genetics.

[17]  P. Coulombe,et al.  Self-organization of keratin intermediate filaments into cross-linked networks , 2009, The Journal of cell biology.

[18]  A. Fischer,et al.  Hematoxylin and eosin staining of tissue and cell sections. , 2008, CSH protocols.

[19]  E. Lane,et al.  The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases , 2008, Human mutation.

[20]  J. Orenstein,et al.  Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research , 2007, Nature Protocols.

[21]  P. Coulombe,et al.  Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm. , 2007, Genes & development.

[22]  M. Omary,et al.  A disease- and phosphorylation-related nonmechanical function for keratin 8 , 2006, The Journal of cell biology.

[23]  P. Coulombe,et al.  A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth , 2006, Nature.

[24]  X. Tong,et al.  Keratin 17 modulates hair follicle cycling in a TNFα-dependent fashion , 2006 .

[25]  Rainer Schmidt,et al.  The cornified envelope: a model of cell death in the skin , 2005, Nature Reviews Molecular Cell Biology.

[26]  R. Gay,et al.  Nucleofection: a new, highly efficient transfection method for primary human keratinocytes * , 2005, Experimental Dermatology.

[27]  M. Omary,et al.  Intermediate filament proteins and their associated diseases. , 2004, The New England journal of medicine.

[28]  E. Lane,et al.  Keratins and skin disorders , 2004, The Journal of pathology.

[29]  X. Tong,et al.  A novel mouse type I intermediate filament gene, keratin 17n (K17n), exhibits preferred expression in nail tissue. , 2004, The Journal of investigative dermatology.

[30]  J. Schweizer,et al.  Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles. , 2003, The Journal of investigative dermatology.

[31]  P. Coulombe,et al.  Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair , 2003, The Journal of cell biology.

[32]  K. McGowan,et al.  Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle. , 2002, The Journal of investigative dermatology.

[33]  P. Coulombe,et al.  An ex vivo assay to assess the potential of skin keratinocytes for wound epithelialization. , 2002, The Journal of investigative dermatology.

[34]  M. Inagaki,et al.  Keratin attenuates tumor necrosis factor–induced cytotoxicity through association with TRADD , 2001, The Journal of cell biology.

[35]  N. Daigle,et al.  Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation , 2001, The Journal of cell biology.

[36]  R Paus,et al.  A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. , 2001, The Journal of investigative dermatology.

[37]  M. Tomic-Canic,et al.  Keratins and the keratinocyte activation cycle. , 2001, The Journal of investigative dermatology.

[38]  D. Wirtz,et al.  A 'hot-spot' mutation alters the mechanical properties of keratin filament networks , 2001, Nature Cell Biology.

[39]  R Paus,et al.  A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. , 1999, The Journal of investigative dermatology.

[40]  Eady,et al.  Specialized keratin expression pattern in human ridged skin as an adaptation to high physical stress , 1998, The British journal of dermatology.

[41]  K. McGowan,et al.  Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development , 1998, The Journal of cell biology.

[42]  P. Coulombe,et al.  The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs. , 1998, Genomics.

[43]  P. Coulombe,et al.  A Proline Residue in the α-Helical Rod Domain of Type I Keratin 16 Destabilizes Keratin Heterotetramers* , 1997, The Journal of Biological Chemistry.

[44]  G. Dotto,et al.  Primary mouse keratinocyte cultures contain hair follicle progenitor cells with multiple differentiation potential. , 1997, The Journal of investigative dermatology.

[45]  C. Byrne.  Regulation of gene expression in developing epidermal epithelia , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

[46]  M. Lussier,et al.  Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage. , 1996, Journal of cell science.

[47]  P. Coulombe,et al.  Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16 , 1996, The Journal of cell biology.

[48]  E. Fuchs,et al.  The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14 , 1995, The Journal of cell biology.

[49]  E. Lane,et al.  Keratin 16 and keratin 17 mutations cause pachyonychia congenita , 1995, Nature Genetics.

[50]  M. Omary,et al.  Empigen BB: a useful detergent for solubilization and biochemical analysis of keratins. , 1995, Biochemical and biophysical research communications.

[51]  W. Franke,et al.  Molecular characterization of the body site-specific human epidermal cytokeratin 9: cDNA cloning, amino acid sequence, and tissue specificity of gene expression. , 1993, Differentiation; research in biological diversity.

[52]  S. Kubicka,et al.  Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation. , 1992, Experimental cell research.

[53]  E. Fuchs,et al.  Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[54]  E. Lane,et al.  A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering , 1992, Nature.

[55]  E. Fuchs,et al.  A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases , 1991, The Journal of cell biology.

[56]  Alana L. Rothman,et al.  Epidermolysis bullosa simplex: evidence in two families for keratin gene abnormalities. , 1991, Science.

[57]  Elaine Fuchs,et al.  Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analyses , 1991, Cell.

[58]  E. Fuchs,et al.  Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro , 1990, The Journal of cell biology.

[59]  E. Fuchs,et al.  Elucidating the early stages of keratin filament assembly , 1990, The Journal of cell biology.

[60]  K Weber,et al.  The coiled coil of in vitro assembled keratin filaments is a heterodimer of type I and II keratins: use of site-specific mutagenesis and recombinant protein expression , 1990, The Journal of cell biology.

[61]  P M Steinert,et al.  Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro , 1989, The Journal of cell biology.

[62]  E. Fuchs,et al.  Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation , 1988, The Journal of cell biology.

[63]  A. Lorincz,et al.  Immunofluorescence localization of peripheral proteins in cultured human keratinocytes. , 1988, The Journal of investigative dermatology.

[64]  A. Steven,et al.  The molecular biology of intermediate filaments , 1985, Cell.

[65]  P. Steinert,et al.  Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies. , 1984, The Journal of biological chemistry.

[66]  R. Eichner,et al.  Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes , 1984, The Journal of cell biology.

[67]  K. Holbrook,et al.  Factors influencing calcium‐induced terminal differentiation in cultured mouse epidermal cells , 1983, Journal of cellular physiology.

[68]  T. Sun,et al.  The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies , 1983, The Journal of cell biology.

[69]  T. Sun,et al.  Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies , 1982, The Journal of cell biology.

[70]  Elaine Fuchs,et al.  Changes in keratin gene expression during terminal differentiation of the keratinocyte , 1980, Cell.

[71]  M. Hayat,et al.  Principles and Techniques of Electron Microscopy: Biological Applications , 1975 .

[72]  Luowei Li.  Mouse epidermal keratinocyte culture. , 2013, Methods in molecular biology.

[73]  J. Reichelt,et al.  Establishment of spontaneously immortalized keratinocyte lines from wild-type and mutant mice. , 2010, Methods in molecular biology.

[74]  S. Yuspa,et al.  Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice , 2008, Nature Protocols.

[75]  R. Fässler,et al.  Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin. , 2007, Methods in enzymology.

[76]  M. Hesse,et al.  Comprehensive analysis of keratin gene clusters in humans and rodents. , 2004, European journal of cell biology.

[77]  P. Coulombe,et al.  Skin: an ideal model system to study keratin genes and proteins. , 2004, Methods in cell biology.

[78]  E. Lane,et al.  Characterization of early assembly intermediates of recombinant human keratins. , 2002, Journal of structural biology.

[79]  M. Omary,et al.  Keratin modifications and solubility properties in epithelial cells and in vitro. , 1998, Sub-cellular biochemistry.

[80]  E. Fuchs.  Keratins and the skin. , 1995, Annual review of cell and developmental biology.

[81]  K Weber,et al.  Intermediate filaments: structure, dynamics, function, and disease. , 1994, Annual review of biochemistry.