IMMUNOSUPPRESSIVE EFFECT OF HUMAN PREGNANCY ZONE PROTEIN ON H‐2 INCOMPATIBLE MOUSE HEART ALLOGRAFT

Human pregnancy zone protein (PZP) given intraveneously, significantly (p<0.001) prolonged the survival of heterotopic A/J heart transplants in A.CA recipients, compared to untreated control recipients, recipients treated with phosphate buffered saline and recipients treated with a control preparation from male serum. The results support the hypothesis that PZP protein exerts an unspecific immunosuppressive effect in vivo.

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